Setting description

Equal randomization: TC3 and TC4 more effective in the HRD+ biomarker signature (cfr scen 5)

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4 TC5
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.112, shape = 1.05
all summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 9.9, median = 7.1 mean = 9.9, median = 7.1 mean = 8.8, median = 6.3
all effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.13, hr = 0.88 af = 1.13, hr = 0.88 af = 1, hr = 1
AR- & TP53- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.096, shape = 1.05 scale = 0.096, shape = 1.05 scale = 0.112, shape = 1.05
AR- & TP53- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 10.2, median = 7.4 mean = 10.2, median = 7.4 mean = 8.8, median = 6.3
AR- & TP53- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.16, hr = 0.85 af = 1.16, hr = 0.85 af = 1, hr = 1
HRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
HRD+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
HRD+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.107, shape = 1.05 scale = 0.107, shape = 1.05 scale = 0.112, shape = 1.05
TP53+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 9.2, median = 6.6 mean = 9.2, median = 6.6 mean = 8.8, median = 6.3
TP53+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.04, hr = 0.96 af = 1.04, hr = 0.96 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.097, shape = 1.05 scale = 0.097, shape = 1.05 scale = 0.112, shape = 1.05
TEfus+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 10.1, median = 7.3 mean = 10.1, median = 7.3 mean = 8.8, median = 6.3
TEfus+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.15, hr = 0.87 af = 1.15, hr = 0.87 af = 1, hr = 1
PI3K+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.104, shape = 1.05 scale = 0.104, shape = 1.05 scale = 0.112, shape = 1.05
PI3K+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 9.4, median = 6.8 mean = 9.4, median = 6.8 mean = 8.8, median = 6.3
PI3K+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.07, hr = 0.93 af = 1.07, hr = 0.93 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4 TC5
—– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
—++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
—++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
–+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
–+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+— effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
-+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
-+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
-+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
-++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
-++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
-+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-+++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-+++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
-++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
-++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
-++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
+—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+—+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+—+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+–++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+–++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
+-+++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
+-+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++— summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++— effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
++–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++–+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
++-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++-+- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
++-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++-++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
+++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
+++– summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
+++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
+++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
+++-+ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
+++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
++++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
++++- summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
++++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1
+++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.036, shape = 1.05 scale = 0.112, shape = 1.05
+++++ summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 27.4, median = 19.7 mean = 27.4, median = 19.7 mean = 8.8, median = 6.3
+++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.12, hr = 0.3 af = 3.12, hr = 0.3 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 4 2 4 7 3
AR- & TP53- 13 8 65 62 10
HRD+ 1 0 220 219 0
TP53+ 4 2 6 4 3
TEfus+ 2 0 6 3 0
PI3K+ 2 3 9 6 1
TC1 TC2 TC3 TC4 TC5
all 0.008 0.004 0.008 0.014 0.006
AR- & TP53- 0.026 0.016 0.130 0.124 0.020
HRD+ 0.002 0.000 0.440 0.438 0.000
TP53+ 0.008 0.004 0.012 0.008 0.006
TEfus+ 0.004 0.000 0.012 0.006 0.000
PI3K+ 0.004 0.006 0.018 0.012 0.002
futility (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 0 3 0 0 5
AR- & TP53- 77 94 4 10 79
HRD+ 61 67 0 0 74
TP53+ 30 36 14 11 30
TEfus+ 8 18 1 3 13
PI3K+ 23 24 9 11 30
TC1 TC2 TC3 TC4 TC5
all 0.000 0.006 0.000 0.000 0.010
AR- & TP53- 0.154 0.188 0.008 0.020 0.158
HRD+ 0.122 0.134 0.000 0.000 0.148
TP53+ 0.060 0.072 0.028 0.022 0.060
TEfus+ 0.016 0.036 0.002 0.006 0.026
PI3K+ 0.046 0.048 0.018 0.022 0.060
max sample size (counts and proportions):
TC1 TC2 TC3 TC4 TC5
all 0 0 0 0 0
AR- & TP53- 8 7 6 5 7
HRD+ 0 0 0 0 0
TP53+ 0 0 0 0 0
TEfus+ 0 0 0 0 0
PI3K+ 0 0 0 0 0
TC1 TC2 TC3 TC4 TC5
all 0.000 0.000 0.000 0.00 0.000
AR- & TP53- 0.016 0.014 0.012 0.01 0.014
HRD+ 0.000 0.000 0.000 0.00 0.000
TP53+ 0.000 0.000 0.000 0.00 0.000
TEfus+ 0.000 0.000 0.000 0.00 0.000
PI3K+ 0.000 0.000 0.000 0.00 0.000


Operating characteristics

char overall TC1 TC2 TC3 TC4 TC5
err_sign 0.344 0.052 0.03 0.136 0.140 0.032
err_type 0.374 0.052 0.03 0.168 0.154 0.032
pow_sign 0.678 0.000 0.00 0.440 0.438 0.000
pow_type 0.788 0.000 0.00 0.576 0.578 0.000

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4 TC5
all graduation 0 4 2 4 7 3
all futility 0 0 3 0 0 5
all max_n 0 0 0 0 0 0
all n 382 (357, 403) 163 (113, 191) 162 (108, 193) 163 (117, 192) 164 (115, 193) 163 (109, 195)
all n_unique 349 (327, 368) 150 (103, 176) 148 (98, 179) 150 (108, 177) 150 (105, 177) 149 (100, 179)
all time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
all time_stop NA (NA, NA) 6 (5, 8) 7 (6, 13) 6 (5, 7) 7 (5, 10) 8 (5, 14)
all post_p NA (NA, NA) 0.51 (0.12, 0.88) 0.44 (0.08, 0.83) 0.97 (0.74, 1) 0.97 (0.73, 1) 0.49 (0.09, 0.89)
all rate 0.112 (0.105, 0.12) 0.112 (0.1, 0.125) 0.113 (0.103, 0.128) 0.091 (0.08, 0.103) 0.091 (0.081, 0.104) 0.112 (0.101, 0.125)
AR- & TP53- graduation 0 13 8 65 62 10
AR- & TP53- futility 0 77 94 4 10 79
AR- & TP53- max_n 0 8 7 6 5 7
AR- & TP53- n 212 (195, 232) 92 (40, 113) 92 (33, 116) 93 (43, 116) 93 (39, 114) 92 (39, 118)
AR- & TP53- n_unique 195 (179, 214) 85 (37, 106) 85 (30, 108) 86 (40, 108) 86 (36, 106) 86 (36, 111)
AR- & TP53- time_trial 36 (36, 36) 36 (15, 36) 36 (15, 36) 36 (19, 36) 36 (18, 36) 36 (17, 36)
AR- & TP53- time_stop NA (NA, NA) 14 (9, 31) 15 (9, 30) 13 (10, 25) 13 (9, 25) 15 (10, 33)
AR- & TP53- post_p NA (NA, NA) 0.48 (0.09, 0.91) 0.41 (0.09, 0.84) 0.95 (0.69, 1) 0.96 (0.65, 1) 0.47 (0.09, 0.86)
AR- & TP53- rate 0.113 (0.102, 0.123) 0.112 (0.095, 0.134) 0.115 (0.1, 0.138) 0.087 (0.072, 0.103) 0.087 (0.073, 0.105) 0.113 (0.097, 0.134)
HRD+ graduation 0 1 0 220 219 0
HRD+ futility 0 61 67 0 0 74
HRD+ max_n 0 0 0 0 0 0
HRD+ n 64 (54, 75) 28 (18, 37) 28 (17, 39) 25 (18, 34) 26 (18, 34) 28 (17, 39)
HRD+ n_unique 58 (48, 69) 25 (15, 34) 25 (15, 35) 23 (16, 30) 24 (16, 31) 25 (15, 35)
HRD+ time_trial 36 (36, 36) 36 (35, 36) 36 (34, 36) 36 (27, 36) 36 (27, 36) 36 (33, 36)
HRD+ time_stop NA (NA, NA) 30 (23, 35) 31 (24, 35) 30 (24, 35) 30 (24, 35) 31 (22, 35)
HRD+ post_p NA (NA, NA) 0.36 (0.08, 0.79) 0.3 (0.05, 0.74) 1 (0.99, 1) 1 (0.99, 1) 0.31 (0.06, 0.73)
HRD+ rate 0.112 (0.094, 0.134) 0.112 (0.084, 0.149) 0.117 (0.088, 0.154) 0.035 (0.024, 0.049) 0.036 (0.024, 0.051) 0.117 (0.087, 0.154)
TP53+ graduation 0 4 2 6 4 3
TP53+ futility 0 30 36 14 11 30
TP53+ max_n 0 0 0 0 0 0
TP53+ n 134 (121, 148) 57 (43, 69) 57 (43, 69) 57 (45, 71) 57 (44, 69) 57 (42, 69)
TP53+ n_unique 122 (110, 135) 51 (38, 63) 51 (38, 63) 52 (40, 64) 52 (39, 63) 52 (38, 62)
TP53+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
TP53+ time_stop NA (NA, NA) 20 (14, 32) 22 (15, 32) 23 (14, 30) 20 (15, 31) 20 (14, 32)
TP53+ post_p NA (NA, NA) 0.5 (0.12, 0.89) 0.5 (0.09, 0.85) 0.67 (0.24, 0.96) 0.64 (0.2, 0.94) 0.51 (0.12, 0.88)
TP53+ rate 0.113 (0.1, 0.127) 0.113 (0.092, 0.138) 0.112 (0.094, 0.141) 0.103 (0.085, 0.126) 0.106 (0.086, 0.129) 0.112 (0.093, 0.139)
TEfus+ graduation 0 2 0 6 3 0
TEfus+ futility 0 8 18 1 3 13
TEfus+ max_n 0 0 0 0 0 0
TEfus+ n 127 (114, 143) 54 (40, 67) 55 (39, 67) 54 (42, 67) 54 (41, 66) 54 (39, 67)
TEfus+ n_unique 116 (103, 129) 49 (35, 61) 50 (34, 61) 48 (38, 60) 49 (37, 59) 49 (36, 61)
TEfus+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
TEfus+ time_stop NA (NA, NA) 22 (16, 30) 22 (16, 33) 18 (15, 31) 25 (17, 30) 20 (15, 24)
TEfus+ post_p NA (NA, NA) 0.48 (0.11, 0.88) 0.46 (0.1, 0.83) 0.89 (0.49, 0.99) 0.88 (0.46, 0.99) 0.48 (0.12, 0.87)
TEfus+ rate 0.113 (0.099, 0.127) 0.112 (0.092, 0.136) 0.114 (0.096, 0.142) 0.089 (0.073, 0.109) 0.09 (0.072, 0.113) 0.112 (0.093, 0.139)
PI3K+ graduation 0 2 3 9 6 1
PI3K+ futility 0 23 24 9 11 30
PI3K+ max_n 0 0 0 0 0 0
PI3K+ n 129 (116, 143) 56 (38, 70) 55 (37, 69) 56 (40, 70) 56 (40, 69) 55 (38, 70)
PI3K+ n_unique 119 (106, 131) 50 (34, 64) 50 (34, 62) 50 (36, 64) 51 (36, 63) 50 (34, 63)
PI3K+ time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
PI3K+ time_stop NA (NA, NA) 23 (15, 30) 23 (14, 30) 19 (14, 28) 18 (14, 25) 23 (13, 33)
PI3K+ post_p NA (NA, NA) 0.49 (0.1, 0.87) 0.46 (0.1, 0.85) 0.78 (0.28, 0.98) 0.74 (0.27, 0.97) 0.5 (0.09, 0.86)
PI3K+ rate 0.113 (0.1, 0.127) 0.112 (0.094, 0.137) 0.114 (0.094, 0.139) 0.099 (0.08, 0.122) 0.1 (0.08, 0.124) 0.113 (0.094, 0.139)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4 TC5
—– graduation 0 17 10 69 67 12
—– futility 0 77 96 4 10 81
—– max_n 0 8 7 6 5 7
—– n 117 (105, 131) 50 (21, 63) 49 (18, 64) 51 (24, 66) 51 (21, 65) 50 (22, 66)
—– n_unique 108 (97, 122) 48 (20, 60) 46 (17, 61) 48 (23, 62) 48 (20, 61) 48 (21, 63)
—– post_p NA (NA, NA) 0.53 (0.12, 0.89) 0.48 (0.1, 0.86) 0.5 (0.13, 0.87) 0.49 (0.12, 0.88) 0.51 (0.13, 0.88)
—– rate 0.113 (0.099, 0.127) 0.112 (0.089, 0.141) 0.115 (0.094, 0.147) 0.112 (0.092, 0.138) 0.113 (0.091, 0.139) 0.113 (0.092, 0.14)
—-+ graduation 0 19 13 75 71 13
—-+ futility 0 93 108 13 21 97
—-+ max_n 0 8 7 6 5 7
—-+ n 30 (23, 38) 13 (5, 19) 12 (4, 19) 13 (5, 19) 13 (5, 19) 13 (5, 19)
—-+ n_unique 27 (20, 35) 12 (5, 17) 11 (4, 17) 12 (5, 17) 12 (4, 18) 12 (5, 17)
—-+ post_p NA (NA, NA) 0.47 (0.18, 0.85) 0.51 (0.16, 0.85) 0.5 (0.16, 0.83) 0.52 (0.16, 0.87) 0.48 (0.16, 0.86)
—-+ rate 0.114 (0.089, 0.149) 0.117 (0.075, 0.18) 0.118 (0.077, 0.191) 0.119 (0.079, 0.176) 0.113 (0.072, 0.178) 0.117 (0.074, 0.193)
—+- graduation 0 19 10 74 68 12
—+- futility 0 83 104 5 12 89
—+- max_n 0 8 7 6 5 7
—+- n 6 (3, 10) 2 (0, 5) 2 (0, 5) 3 (0, 5) 2 (0, 5) 2 (0, 5)
—+- n_unique 5 (2, 9) 2 (0, 5) 2 (0, 4) 2 (0, 5) 2 (0, 4) 2 (0, 5)
—+- post_p NA (NA, NA) 0.49 (0.27, 0.75) 0.49 (0.28, 0.75) 0.47 (0.26, 0.74) 0.48 (0.28, 0.72) 0.5 (0.28, 0.76)
—+- rate 0.117 (0.062, 0.228) 0.12 (0.041, 0.363) 0.126 (0.039, 0.381) 0.132 (0.046, 0.342) 0.129 (0.045, 0.377) 0.118 (0.045, 0.411)
—++ graduation 0 21 13 79 72 13
—++ futility 0 97 114 14 22 103
—++ max_n 0 8 7 6 5 7
—++ n 14 (10, 19) 6 (2, 10) 6 (2, 10) 6 (2, 10) 6 (2, 10) 6 (2, 10)
—++ n_unique 13 (8, 18) 5 (2, 9) 5 (2, 9) 5 (2, 9) 5 (2, 9) 5 (2, 9)
—++ post_p NA (NA, NA) 0.48 (0.2, 0.81) 0.47 (0.2, 0.81) 0.53 (0.21, 0.83) 0.53 (0.22, 0.82) 0.46 (0.2, 0.81)
—++ rate 0.118 (0.079, 0.176) 0.122 (0.068, 0.24) 0.124 (0.067, 0.267) 0.116 (0.06, 0.219) 0.115 (0.063, 0.235) 0.124 (0.066, 0.241)
–+– graduation 0 8 4 10 11 6
–+– futility 0 30 38 14 11 33
–+– max_n 0 0 0 0 0 0
–+– n 28 (21, 35) 12 (7, 16) 11 (7, 16) 12 (7, 17) 12 (7, 17) 12 (7, 17)
–+– n_unique 25 (19, 33) 10 (6, 15) 10 (6, 15) 11 (7, 15) 11 (6, 15) 11 (6, 16)
–+– post_p NA (NA, NA) 0.51 (0.14, 0.85) 0.5 (0.17, 0.84) 0.49 (0.16, 0.82) 0.48 (0.17, 0.83) 0.49 (0.16, 0.86)
–+– rate 0.111 (0.086, 0.147) 0.112 (0.073, 0.182) 0.115 (0.075, 0.177) 0.115 (0.075, 0.174) 0.116 (0.076, 0.178) 0.115 (0.072, 0.177)
–+-+ graduation 0 10 7 18 16 7
–+-+ futility 0 48 58 21 20 54
–+-+ max_n 0 0 0 0 0 0
–+-+ n 26 (20, 33) 11 (7, 16) 11 (6, 16) 11 (7, 16) 11 (7, 16) 11 (6, 15)
–+-+ n_unique 24 (18, 30) 10 (6, 15) 10 (5, 14) 10 (6, 15) 10 (6, 15) 10 (5, 14)
–+-+ post_p NA (NA, NA) 0.51 (0.17, 0.83) 0.5 (0.17, 0.83) 0.53 (0.17, 0.87) 0.48 (0.19, 0.82) 0.49 (0.16, 0.85)
–+-+ rate 0.116 (0.083, 0.15) 0.117 (0.075, 0.182) 0.114 (0.078, 0.174) 0.113 (0.071, 0.18) 0.114 (0.077, 0.172) 0.116 (0.07, 0.189)
–++- graduation 0 10 4 16 14 6
–++- futility 0 36 50 14 14 39
–++- max_n 0 0 0 0 0 0
–++- n 8 (5, 12) 3 (1, 6) 3 (1, 6) 3 (1, 6) 3 (1, 6) 3 (1, 6)
–++- n_unique 7 (4, 11) 3 (1, 6) 3 (1, 6) 3 (1, 6) 3 (1, 6) 3 (1, 6)
–++- post_p NA (NA, NA) 0.49 (0.27, 0.78) 0.46 (0.23, 0.75) 0.51 (0.26, 0.77) 0.5 (0.27, 0.79) 0.46 (0.23, 0.75)
–++- rate 0.114 (0.068, 0.199) 0.12 (0.051, 0.297) 0.126 (0.057, 0.315) 0.112 (0.055, 0.321) 0.118 (0.048, 0.302) 0.13 (0.047, 0.346)
–+++ graduation 0 12 7 22 18 7
–+++ futility 0 53 67 21 22 59
–+++ max_n 0 0 0 0 0 0
–+++ n 20 (15, 27) 9 (5, 13) 8 (4, 12) 9 (5, 14) 9 (5, 13) 8 (4, 13)
–+++ n_unique 19 (13, 25) 8 (4, 12) 7 (4, 12) 8 (4, 12) 8 (4, 12) 8 (4, 12)
–+++ post_p NA (NA, NA) 0.49 (0.19, 0.82) 0.48 (0.14, 0.84) 0.53 (0.2, 0.86) 0.47 (0.19, 0.83) 0.5 (0.18, 0.84)
–+++ rate 0.112 (0.084, 0.159) 0.117 (0.071, 0.204) 0.117 (0.069, 0.214) 0.111 (0.068, 0.185) 0.119 (0.071, 0.197) 0.114 (0.067, 0.2)
-+— graduation 0 18 10 278 278 12
-+— futility 0 130 159 4 10 143
-+— max_n 0 7 7 5 5 7
-+— n 26 (20, 32) 11 (5, 17) 11 (4, 18) 11 (5, 16) 11 (5, 16) 11 (5, 18)
-+— n_unique 24 (17, 30) 10 (4, 15) 10 (4, 16) 10 (5, 14) 10 (4, 15) 10 (4, 16)
-+— post_p NA (NA, NA) 0.34 (0.1, 0.7) 0.33 (0.09, 0.72) 0.97 (0.79, 1) 0.97 (0.77, 1) 0.32 (0.1, 0.7)
-+— rate 0.112 (0.084, 0.15) 0.118 (0.074, 0.19) 0.119 (0.078, 0.195) 0.036 (0.018, 0.06) 0.036 (0.016, 0.06) 0.117 (0.076, 0.191)
-+–+ graduation 0 20 13 281 281 12
-+–+ futility 0 143 169 12 19 154
-+–+ max_n 0 7 7 5 5 7
-+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+–+ post_p NA (NA, NA) 0.46 (0.44, 0.47) 0.5 (0.47, 0.53) 0.53 (0.48, 0.54) 0.55 (0.54, 0.56) 0.49 (0.45, 0.54)
-+–+ rate 0.123 (0, 0.405) 0.257 (0.098, 0.624) 0.311 (0.047, 0.665) 0.06 (0, 0.782) 0.038 (0, 0.197) 0.339 (0.036, 5.583)
-+-+- graduation 0 20 10 281 277 12
-+-+- futility 0 134 166 5 12 149
-+-+- max_n 0 7 7 5 5 7
-+-+- n 13 (9, 18) 5 (2, 10) 5 (2, 10) 5 (2, 9) 5 (2, 9) 6 (2, 10)
-+-+- n_unique 12 (7, 17) 5 (1, 9) 5 (2, 9) 4 (2, 8) 4 (2, 8) 5 (1, 9)
-+-+- post_p NA (NA, NA) 0.4 (0.17, 0.7) 0.4 (0.16, 0.67) 0.86 (0.57, 0.98) 0.85 (0.56, 0.97) 0.39 (0.19, 0.67)
-+-+- rate 0.12 (0.078, 0.174) 0.117 (0.062, 0.237) 0.121 (0.061, 0.282) 0.035 (0.011, 0.08) 0.036 (0.014, 0.087) 0.122 (0.061, 0.235)
-+-++ graduation 0 22 13 283 280 12
-+-++ futility 0 146 174 13 20 159
-+-++ max_n 0 7 7 5 5 7
-+-++ n 6 (3, 9) 2 (0, 5) 2 (0, 5) 2 (0, 5) 2 (0, 5) 2 (0, 5)
-+-++ n_unique 5 (2, 8) 2 (0, 4) 2 (0, 5) 2 (0, 4) 2 (0, 4) 2 (0, 4)
-+-++ post_p NA (NA, NA) 0.44 (0.27, 0.66) 0.44 (0.27, 0.63) 0.67 (0.47, 0.87) 0.67 (0.44, 0.87) 0.44 (0.27, 0.64)
-+-++ rate 0.113 (0.056, 0.217) 0.119 (0.04, 0.35) 0.123 (0.049, 0.407) 0.034 (0, 0.121) 0.033 (0, 0.138) 0.12 (0.042, 0.419)
-++– graduation 0 8 3 227 230 5
-++– futility 0 86 99 12 9 102
-++– max_n 0 0 0 0 0 0
-++– n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-++– post_p NA (NA, NA) 0.47 (0.47, 0.48) 0.49 (0.47, 0.52) 0.5 (0.5, 0.5) NA (NA, NA) 0.43 (0.43, 0.43)
-++– rate 0.088 (0, 0.609) 0.219 (0, 0.976) 0.134 (0, 1.078) 0 (0, 0.376) 0.072 (0, 0.107) 0.198 (0, 0.614)
-++-+ graduation 0 10 6 232 234 5
-++-+ futility 0 101 116 18 16 119
-++-+ max_n 0 0 0 0 0 0
-++-+ n 3 (1, 6) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
-++-+ n_unique 3 (1, 6) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
-++-+ post_p NA (NA, NA) 0.45 (0.3, 0.62) 0.44 (0.32, 0.63) 0.61 (0.43, 0.8) 0.6 (0.43, 0.81) 0.45 (0.31, 0.61)
-++-+ rate 0.115 (0.044, 0.307) 0.133 (0, 0.565) 0.14 (0.034, 0.528) 0.035 (0, 0.179) 0.032 (0, 0.209) 0.136 (0.027, 0.581)
-+++- graduation 0 10 3 231 231 5
-+++- futility 0 89 111 12 12 106
-+++- max_n 0 0 0 0 0 0
-+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
-+++- post_p NA (NA, NA) 0.57 (0.53, 0.6) 0.41 (0.4, 0.53) NA (NA, NA) 0.62 (0.56, 0.67) 0.48 (0.48, 0.48)
-+++- rate 0.104 (0, 0.823) 0.122 (0, 0.696) 0.125 (0.021, 0.385) 0.076 (0, 0.291) 0 (0, 0.145) 0.141 (0, 0.539)
-++++ graduation 0 12 6 234 234 5
-++++ futility 0 104 125 18 18 122
-++++ max_n 0 0 0 0 0 0
-++++ n 3 (1, 6) 1 (0, 3) 2 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 4)
-++++ n_unique 3 (1, 6) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
-++++ post_p NA (NA, NA) 0.45 (0.34, 0.64) 0.44 (0.31, 0.63) 0.62 (0.44, 0.81) 0.61 (0.44, 0.81) 0.46 (0.3, 0.64)
-++++ rate 0.12 (0.052, 0.321) 0.126 (0, 0.433) 0.133 (0.028, 0.461) 0.028 (0, 0.135) 0.032 (0, 0.148) 0.129 (0, 0.506)
+—- graduation 0 4 2 4 7 3
+—- futility 0 0 3 0 0 5
+—- max_n 0 0 0 0 0 0
+—- n 6 (3, 10) 2 (1, 5) 2 (0, 5) 2 (1, 5) 2 (1, 5) 2 (1, 5)
+—- n_unique 5 (3, 9) 2 (0, 4) 2 (0, 4) 2 (1, 5) 2 (0, 4) 2 (0, 4)
+—- post_p NA (NA, NA) 0.49 (0.28, 0.71) 0.48 (0.3, 0.72) 0.5 (0.29, 0.74) 0.47 (0.27, 0.7) 0.48 (0.27, 0.71)
+—- rate 0.111 (0.062, 0.217) 0.123 (0.052, 0.365) 0.125 (0.045, 0.331) 0.116 (0.03, 0.389) 0.127 (0.046, 0.363) 0.122 (0.042, 0.363)
+—+ graduation 0 6 5 13 13 4
+—+ futility 0 23 27 9 11 34
+—+ max_n 0 0 0 0 0 0
+—+ n 3 (1, 5) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3) 1 (0, 3)
+—+ n_unique 2 (1, 5) 1 (0, 3) 1 (0, 3) 1 (0, 2) 1 (0, 3) 1 (0, 2)
+—+ post_p NA (NA, NA) 0.47 (0.32, 0.66) 0.49 (0.36, 0.67) 0.48 (0.35, 0.66) 0.48 (0.37, 0.69) 0.48 (0.35, 0.7)
+—+ rate 0.121 (0.036, 0.346) 0.139 (0, 0.6) 0.123 (0, 0.658) 0.145 (0, 0.666) 0.131 (0, 0.659) 0.126 (0, 0.634)
+–+- graduation 0 6 2 10 10 3
+–+- futility 0 8 20 1 3 18
+–+- max_n 0 0 0 0 0 0
+–+- n 9 (5, 13) 4 (2, 6) 4 (1, 6) 4 (1, 7) 4 (2, 7) 4 (1, 7)
+–+- n_unique 8 (5, 12) 3 (1, 6) 3 (1, 6) 3 (1, 6) 4 (1, 6) 3 (1, 6)
+–+- post_p NA (NA, NA) 0.5 (0.25, 0.75) 0.49 (0.28, 0.75) 0.48 (0.25, 0.78) 0.51 (0.25, 0.78) 0.49 (0.23, 0.77)
+–+- rate 0.119 (0.069, 0.193) 0.119 (0.05, 0.262) 0.12 (0.054, 0.259) 0.122 (0.047, 0.264) 0.115 (0.051, 0.282) 0.119 (0.05, 0.294)
+–++ graduation 0 8 5 17 15 4
+–++ futility 0 29 39 10 13 43
+–++ max_n 0 0 0 0 0 0
+–++ n 4 (2, 8) 2 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 4) 2 (0, 4)
+–++ n_unique 4 (2, 7) 2 (0, 4) 2 (0, 4) 1 (0, 4) 2 (0, 4) 2 (0, 3)
+–++ post_p NA (NA, NA) 0.49 (0.31, 0.73) 0.48 (0.31, 0.7) 0.49 (0.31, 0.73) 0.48 (0.31, 0.71) 0.5 (0.32, 0.71)
+–++ rate 0.12 (0.056, 0.259) 0.125 (0.037, 0.397) 0.124 (0.04, 0.46) 0.125 (0.028, 0.437) 0.126 (0.029, 0.416) 0.118 (0.009, 0.456)
+-+– graduation 0 8 4 10 11 6
+-+– futility 0 30 38 14 11 33
+-+– max_n 0 0 0 0 0 0
+-+– n 2 (0, 4) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– n_unique 2 (0, 4) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
+-+– post_p NA (NA, NA) 0.49 (0.37, 0.61) 0.48 (0.38, 0.66) 0.49 (0.38, 0.64) 0.51 (0.37, 0.65) 0.48 (0.39, 0.62)
+-+– rate 0.13 (0.032, 0.428) 0.12 (0, 0.64) 0.136 (0, 0.8) 0.122 (0, 0.716) 0.123 (0, 0.781) 0.138 (0, 0.743)
+-+-+ graduation 0 10 7 18 16 7
+-+-+ futility 0 48 58 21 20 54
+-+-+ max_n 0 0 0 0 0 0
+-+-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+-+-+ post_p NA (NA, NA) 0.46 (0.46, 0.46) 0.55 (0.54, 0.55) 0.5 (0.45, 0.51) 0.57 (0.57, 0.57) 0.48 (0.46, 0.58)
+-+-+ rate 0.199 (0, 0.85) 0.197 (0, 1.492) 0.125 (0, 1.01) 0.099 (0, 0.475) 0.142 (0, 0.915) 0.121 (0, 0.457)
+-++- graduation 0 10 4 16 14 6
+-++- futility 0 36 50 14 14 39
+-++- max_n 0 0 0 0 0 0
+-++- n 22 (17, 29) 9 (5, 14) 9 (5, 14) 9 (5, 14) 10 (5, 14) 9 (5, 14)
+-++- n_unique 20 (15, 26) 9 (4, 13) 8 (5, 13) 8 (4, 13) 8 (4, 13) 8 (4, 13)
+-++- post_p NA (NA, NA) 0.5 (0.18, 0.85) 0.48 (0.15, 0.8) 0.51 (0.18, 0.81) 0.5 (0.18, 0.84) 0.51 (0.17, 0.84)
+-++- rate 0.113 (0.086, 0.151) 0.113 (0.073, 0.195) 0.119 (0.07, 0.205) 0.114 (0.074, 0.191) 0.115 (0.068, 0.194) 0.115 (0.07, 0.192)
+-+++ graduation 0 12 7 22 18 7
+-+++ futility 0 53 67 21 22 59
+-+++ max_n 0 0 0 0 0 0
+-+++ n 17 (12, 23) 7 (3, 11) 7 (3, 12) 7 (4, 11) 7 (4, 11) 7 (3, 11)
+-+++ n_unique 16 (11, 21) 7 (3, 10) 7 (3, 11) 7 (3, 10) 7 (3, 10) 7 (3, 10)
+-+++ post_p NA (NA, NA) 0.49 (0.2, 0.83) 0.48 (0.19, 0.81) 0.48 (0.19, 0.82) 0.47 (0.18, 0.81) 0.51 (0.2, 0.84)
+-+++ rate 0.112 (0.078, 0.155) 0.116 (0.066, 0.204) 0.116 (0.065, 0.224) 0.12 (0.066, 0.203) 0.12 (0.066, 0.213) 0.111 (0.06, 0.223)
++— graduation 0 5 2 224 226 3
++— futility 0 61 70 0 0 79
++— max_n 0 0 0 0 0 0
++— n 9 (6, 14) 4 (2, 7) 4 (2, 7) 4 (1, 7) 4 (1, 7) 4 (2, 7)
++— n_unique 9 (5, 13) 4 (1, 6) 4 (1, 6) 3 (1, 6) 3 (1, 6) 3 (1, 7)
++— post_p NA (NA, NA) 0.41 (0.18, 0.66) 0.4 (0.17, 0.65) 0.77 (0.51, 0.94) 0.77 (0.5, 0.93) 0.4 (0.18, 0.67)
++— rate 0.11 (0.07, 0.183) 0.121 (0.053, 0.261) 0.12 (0.055, 0.301) 0.033 (0, 0.095) 0.036 (0, 0.096) 0.119 (0.055, 0.294)
++–+ graduation 0 7 5 229 231 3
++–+ futility 0 81 91 8 9 101
++–+ max_n 0 0 0 0 0 0
++–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++–+ post_p NA (NA, NA) NA (NA, NA) 0.5 (0.49, 0.52) 0.52 (0.5, 0.54) 0.53 (0.47, 0.66) 0.42 (0.42, 0.42)
++–+ rate 0.12 (0, 0.71) 0.166 (0, 0.273) 0.128 (0, 0.337) 0 (0, 0.238) 0 (0, 0.182) 0.22 (0, 1.846)
++-+- graduation 0 7 2 228 227 3
++-+- futility 0 66 86 1 3 89
++-+- max_n 0 0 0 0 0 0
++-+- n 1 (0, 3) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 1)
++-+- n_unique 1 (0, 3) 0 (0, 2) 0 (0, 2) 0 (0, 1) 0 (0, 2) 0 (0, 1)
++-+- post_p NA (NA, NA) 0.47 (0.4, 0.61) 0.46 (0.37, 0.6) 0.56 (0.42, 0.63) 0.56 (0.44, 0.65) 0.49 (0.39, 0.59)
++-+- rate 0.144 (0, 0.418) 0.125 (0, 0.551) 0.147 (0, 0.626) 0.032 (0, 0.222) 0.032 (0, 0.201) 0.118 (0, 0.894)
++-++ graduation 0 9 5 231 231 3
++-++ futility 0 85 102 9 11 108
++-++ max_n 0 0 0 0 0 0
++-++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++-++ post_p NA (NA, NA) 0.49 (0.48, 0.5) 0.44 (0.44, 0.44) NA (NA, NA) 0.46 (0.44, 0.54) 0.49 (0.45, 0.51)
++-++ rate 0.088 (0, 0.84) 0.11 (0, 0.973) 0.1 (0, 0.324) 0 (0, 0.197) 0 (0, 0.719) 0.124 (0, 0.269)
+++– graduation 0 8 3 227 230 5
+++– futility 0 86 99 12 9 102
+++– max_n 0 0 0 0 0 0
+++– n 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– n_unique 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
+++– post_p NA (NA, NA) 0.46 (0.39, 0.52) 0.48 (0.44, 0.55) 0.56 (0.46, 0.61) 0.54 (0.46, 0.6) 0.5 (0.44, 0.57)
+++– rate 0.135 (0, 0.549) 0.136 (0, 0.974) 0.153 (0, 1.018) 0 (0, 0.246) 0.068 (0, 0.805) 0.185 (0, 0.574)
+++-+ graduation 0 10 6 232 234 5
+++-+ futility 0 101 116 18 16 119
+++-+ max_n 0 0 0 0 0 0
+++-+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++-+ post_p NA (NA, NA) 0.54 (0.52, 0.58) 0.57 (0.49, 0.58) 0.54 (0.51, 0.58) 0.48 (0.44, 0.52) NA (NA, NA)
+++-+ rate 0.129 (0, 0.838) 0.11 (0, 0.479) 0.148 (0, 0.746) 0 (0, 0.139) 0.067 (0, 0.467) 0.026 (0, 0.421)
++++- graduation 0 10 3 231 231 5
++++- futility 0 89 111 12 12 106
++++- max_n 0 0 0 0 0 0
++++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++- post_p NA (NA, NA) NA (NA, NA) 0.51 (0.49, 0.51) 0.52 (0.51, 0.54) NA (NA, NA) NA (NA, NA)
++++- rate 0.127 (0, 0.81) 0.104 (0, 0.302) 0.089 (0, 0.386) 0.044 (0, 0.399) 0.075 (0, 0.23) 0.092 (0, 0.561)
+++++ graduation 0 12 6 234 234 5
+++++ futility 0 104 125 18 18 122
+++++ max_n 0 0 0 0 0 0
+++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++++ post_p NA (NA, NA) 0.48 (0.48, 0.48) 0.51 (0.5, 0.54) 0.5 (0.46, 0.53) 0.5 (0.47, 0.52) 0.49 (0.47, 0.51)
+++++ rate 0.148 (0, 0.413) 0.177 (0.015, 1.408) 0.117 (0, 0.402) 0 (0, 0.229) 0 (0, 0.299) 0.091 (0, 0.891)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4 TC5
all count 4 2 4 7 3
all time_stop 6 (5, 8) 7 (7, 7) 6 (5, 7) 7 (5, 10) 5 (5, 9)
all n_trt 28 (26, 33) 26 (26, 27) 32 (27, 38) 34 (28, 48) 27 (25, 43)
all n_control 48 (39, 70) 64 (61, 67) 64 (49, 68) 69 (36, 90) 40 (33, 83)
all post_p 0.89 (0.87, 0.96) 0.95 (0.92, 0.97) 0.98 (0.96, 0.99) 0.98 (0.95, 1) 0.9 (0.89, 0.98)
all order 1 (1, 1) 1.5 (1.1, 1.9) 1 (1, 1) 1 (1, 2) 1 (1, 1)
AR- & TP53- count 13 8 65 62 10
AR- & TP53- time_stop 11 (9, 13) 12 (10, 18) 14 (10, 26) 14 (9, 27) 14 (11, 17)
AR- & TP53- n_trt 28 (25, 39) 30 (26, 44) 33 (26, 77) 35 (26, 69) 34 (27, 37)
AR- & TP53- n_control 60 (47, 78) 71 (50, 103) 73 (51, 158) 78 (48, 146) 72 (42, 89)
AR- & TP53- post_p 0.92 (0.88, 0.99) 0.94 (0.88, 0.98) 0.98 (0.92, 1) 0.97 (0.88, 1) 0.93 (0.87, 0.99)
AR- & TP53- order 1 (1, 1) 1 (1, 2) 1 (1, 2) 1 (1, 2) 1 (1, 1.2)
HRD+ count 1 220 219
HRD+ time_stop 36 (36, 36) 30 (24, 35) 30 (24, 35)
HRD+ n_trt 25 (25, 25) 26 (25, 30) 26 (25, 31)
HRD+ n_control 63 (63, 63) 54 (40, 68) 53 (41, 68)
HRD+ post_p 1 (1, 1) 1 (0.99, 1) 1 (0.99, 1)
HRD+ order 2 (2, 2) 2 (1, 2) 1 (1, 2)
TP53+ count 4 2 6 4 3
TP53+ time_stop 18 (16, 22) 24 (22, 26) 21 (16, 24) 22 (17, 31) 18 (16, 24)
TP53+ n_trt 28 (26, 34) 27 (25, 29) 30 (27, 34) 34 (25, 47) 26 (26, 38)
TP53+ n_control 64 (53, 82) 94 (89, 98) 73 (56, 96) 80 (64, 106) 65 (58, 83)
TP53+ post_p 0.96 (0.89, 0.99) 0.97 (0.96, 0.99) 0.97 (0.89, 0.99) 1 (0.99, 1) 0.99 (0.95, 0.99)
TP53+ order 1 (1, 1) 1.5 (1.1, 1.9) 1 (1, 2) 1.5 (1, 2.7) 2 (1.2, 2)
TEfus+ count 2 6 3
TEfus+ time_stop 20 (20, 21) 22 (15, 32) 19 (16, 25)
TEfus+ n_trt 29 (27, 31) 32 (25, 50) 27 (25, 31)
TEfus+ n_control 84 (77, 91) 78 (52, 112) 84 (58, 88)
TEfus+ post_p 0.99 (0.98, 0.99) 0.99 (0.98, 1) 1 (0.89, 1)
TEfus+ order 1 (1, 1) 1 (1, 1.5) 2 (1.2, 2.8)
PI3K+ count 2 3 9 6 1
PI3K+ time_stop 20 (18, 22) 20 (16, 24) 22 (13, 28) 18 (16, 22) 23 (23, 23)
PI3K+ n_trt 31 (29, 33) 32 (26, 34) 30 (26, 35) 29 (25, 30) 32 (32, 32)
PI3K+ n_control 75 (70, 80) 68 (63, 82) 81 (44, 95) 58 (49, 72) 71 (71, 71)
PI3K+ post_p 0.96 (0.93, 0.99) 0.97 (0.89, 0.99) 0.99 (0.98, 1) 0.97 (0.93, 0.99) 0.97 (0.97, 0.97)
PI3K+ order 1.5 (1.1, 1.9) 2 (1.2, 2) 2 (1, 3.2) 1 (1, 2) 1 (1, 1)
Futility:
signature var TC1 TC2 TC3 TC4 TC5
all count 3 5
all time_stop 8 (6, 14) 10 (6, 14)
all n_trt 39 (31, 61) 48 (29, 64)
all n_control 85 (43, 166) 109 (42, 137)
all post_p 0.04 (0.02, 0.08) 0.05 (0, 0.17)
all order 1 (1, 1.8) 1 (1, 2.2)
AR- & TP53- count 77 94 4 10 79
AR- & TP53- time_stop 15 (9, 32) 15 (9, 30) 11 (10, 11) 12 (9, 16) 15 (10, 33)
AR- & TP53- n_trt 41 (26, 83) 34 (26, 81) 27 (26, 33) 28 (25, 44) 39 (27, 86)
AR- & TP53- n_control 86 (46, 184) 86 (47, 174) 58 (55, 60) 61 (39, 87) 83 (52, 197)
AR- & TP53- post_p 0.14 (0.04, 0.23) 0.11 (0.02, 0.23) 0.11 (0.03, 0.19) 0.16 (0.05, 0.26) 0.1 (0.04, 0.26)
AR- & TP53- order 1 (1, 3) 1 (1, 3) 1 (1, 1.7) 1 (1, 1.1) 1 (1, 2.2)
HRD+ count 61 67 74
HRD+ time_stop 30 (23, 35) 31 (24, 35) 31 (22, 35)
HRD+ n_trt 26 (25, 34) 26 (25, 33) 26 (25, 33)
HRD+ n_control 52 (36, 64) 57 (44, 69) 54 (39, 65)
HRD+ post_p 0.12 (0.02, 0.24) 0.09 (0.02, 0.22) 0.13 (0.03, 0.25)
HRD+ order 2 (1, 4) 2 (1, 4) 2 (1, 3)
TP53+ count 30 36 14 11 30
TP53+ time_stop 22 (14, 32) 22 (14, 32) 24 (13, 33) 20 (14, 29) 20 (14, 32)
TP53+ n_trt 32 (26, 51) 34 (26, 52) 32 (25, 48) 36 (25, 43) 30 (25, 47)
TP53+ n_control 82 (46, 122) 80 (56, 123) 84 (46, 129) 75 (46, 110) 73 (50, 125)
TP53+ post_p 0.05 (0.02, 0.13) 0.03 (0, 0.16) 0.06 (0.01, 0.17) 0.1 (0.02, 0.2) 0.06 (0.02, 0.18)
TP53+ order 1 (1, 3) 1 (1, 2.5) 1 (1, 2.7) 1 (1, 2) 1.5 (1, 4)
TEfus+ count 8 18 1 3 13
TEfus+ time_stop 23 (16, 31) 22 (16, 33) 16 (16, 16) 30 (25, 30) 20 (15, 24)
TEfus+ n_trt 35 (28, 39) 32 (26, 42) 26 (26, 26) 33 (31, 35) 27 (25, 37)
TEfus+ n_control 76 (58, 107) 71 (53, 127) 62 (62, 62) 108 (94, 121) 67 (50, 90)
TEfus+ post_p 0.03 (0.02, 0.14) 0.05 (0, 0.17) 0.18 (0.18, 0.18) 0.06 (0.02, 0.11) 0.06 (0.01, 0.16)
TEfus+ order 1.5 (1, 3.3) 2 (1, 4) 1 (1, 1) 3 (1.4, 3.8) 2 (1, 3.8)
PI3K+ count 23 24 9 11 30
PI3K+ time_stop 23 (15, 30) 24 (14, 30) 18 (15, 22) 18 (14, 28) 23 (13, 33)
PI3K+ n_trt 33 (25, 47) 28 (25, 45) 31 (25, 37) 27 (26, 33) 30 (26, 44)
PI3K+ n_control 82 (52, 110) 80 (46, 104) 61 (49, 77) 63 (44, 104) 86 (46, 118)
PI3K+ post_p 0.07 (0.01, 0.23) 0.08 (0.01, 0.22) 0.16 (0.02, 0.26) 0.1 (0.04, 0.19) 0.06 (0.02, 0.16)
PI3K+ order 2 (1, 3) 2 (1, 4) 2 (1, 2.2) 1 (1, 2) 2 (1, 4)


By subgroup combinations

Graduation:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC1 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC1 time 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8)
all TC1 n 8 (7, 14) 2 (1, 3) 0 (0, 1) 2 (1, 4) 2 (0, 5) 4 (1, 5) 0 (0, 2) 1 (1, 2) 2 (0, 4) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 2 (1, 2) 2 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.68 (0.6, 0.78) 0.57 (0.56, 0.58) 0.53 (0.53, 0.53) 0.55 (0.54, 0.57) 0.59 (0.55, 0.59) 0.55 (0.52, 0.58) 0.52 (0.52, 0.52) 0.55 (0.51, 0.6) 0.56 (0.56, 0.56) NA (NA, NA) 0.59 (0.55, 0.64) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.55 (0.53, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.54 (0.51, 0.55) 0.53 (0.52, 0.59) 0.52 (0.51, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.049 (0.041, 0.072) 0.147 (0.029, 0.219) 0 (0, 0) 0.042 (0, 1.465) 0 (0, 0.034) 0 (0, 0.063) 0 (0, 0) 0 (0, 13.89) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.375 (0.375, 0.375) NA (NA, NA) NA (NA, NA) 0 (0, 0.104) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC2 time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
all TC2 n 7 (6, 8) 2 (1, 4) 1 (1, 1) 3 (3, 3) 1 (0, 2) 1 (1, 1) 0 (0, 1) 1 (1, 1) 2 (1, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 0 (0, 1) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 3 (3, 3) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.63 (0.59, 0.66) 0.64 (0.59, 0.69) 0.52 (0.52, 0.52) 0.53 (0.53, 0.53) 0.56 (0.56, 0.56) 0.54 (0.53, 0.54) 0.56 (0.56, 0.56) 0.56 (0.54, 0.58) 0.53 (0.52, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.5 (0.5, 0.5) 0.53 (0.53, 0.53) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.59 (0.57, 0.61) 0.57 (0.57, 0.57) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.064 (0.048, 0.08) 0.03 (0.006, 0.055) 0 (0, 0) 0.085 (0.076, 0.094) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.381 (0.206, 0.555) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC3 time 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7)
all TC3 n 8 (6, 11) 2 (1, 2) 0 (0, 1) 2 (1, 2) 2 (1, 4) 2 (0, 3) 0 (0, 1) 1 (0, 3) 3 (1, 5) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 1) 1 (0, 1) 0 (0, 0) 1 (0, 1) 0 (0, 1) 0 (0, 2) 0 (0, 3) 0 (0, 1) 0 (0, 2) 0 (0, 0) 4 (1, 4) 1 (1, 2) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.66 (0.52, 0.83) 0.55 (0.52, 0.58) 0.51 (0.51, 0.51) 0.53 (0.51, 0.54) 0.55 (0.54, 0.55) 0.56 (0.52, 0.63) 0.54 (0.54, 0.54) 0.55 (0.53, 0.56) 0.62 (0.58, 0.67) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) 0.51 (0.51, 0.51) NA (NA, NA) 0.53 (0.52, 0.55) NA (NA, NA) 0.55 (0.55, 0.55) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.61 (0.58, 0.72) 0.51 (0.5, 0.62) 0.6 (0.58, 0.61) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC3 rate 0.084 (0.049, 0.102) 0 (0, 0.105) 0 (0, 0) 0 (0, 0.132) 0.035 (0, 0.073) 0 (0, 0) 0.413 (0.083, 0.744) 0 (0, 0.126) 0 (0, 0.029) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.376 (0.376, 0.376) 0 (0, 0.309) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.054 (0.011, 0.097) 0 (0, 0) 0.235 (0.201, 0.269) NA (NA, NA) 0.077 (0.015, 0.084) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 count 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
all TC4 time 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10) 7 (5, 10)
all TC4 n 13 (7, 15) 4 (1, 4) 0 (0, 2) 0 (0, 1) 4 (2, 5) 1 (0, 4) 0 (0, 0) 2 (0, 3) 3 (2, 4) 0 (0, 0) 2 (0, 4) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 0) 0 (0, 0) 1 (1, 4) 1 (1, 4) 0 (0, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.73 (0.61, 0.91) 0.59 (0.55, 0.67) 0.52 (0.52, 0.64) NA (NA, NA) 0.56 (0.51, 0.59) 0.55 (0.53, 0.61) NA (NA, NA) 0.59 (0.53, 0.67) 0.56 (0.55, 0.7) NA (NA, NA) 0.63 (0.6, 0.64) 0.56 (0.55, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.58 (0.56, 0.64) 0.55 (0.55, 0.55) NA (NA, NA) 0.53 (0.53, 0.53) 0.61 (0.61, 0.61) 0.56 (0.56, 0.56) NA (NA, NA) 0.54 (0.53, 0.63) 0.55 (0.54, 0.62) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
all TC4 rate 0.036 (0, 0.082) 0 (0, 0.061) 0 (0, 0.052) 0 (0, 0) 0.104 (0, 0.167) 0.018 (0, 0.079) NA (NA, NA) 0.077 (0, 0.151) 0 (0, 0.016) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0.191) NA (NA, NA) 0 (0, 0.118) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.09) 0 (0, 0.081) 0 (0, 0.12) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
all TC5 time 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9) 5 (5, 9)
all TC5 n 10 (8, 10) 0 (0, 3) 0 (0, 1) 1 (1, 5) 4 (2, 6) 2 (0, 2) 1 (0, 3) 2 (0, 4) 3 (3, 4) 0 (0, 0) 0 (0, 1) 1 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 2) 0 (0, 0) 0 (0, 0) 2 (1, 3) 2 (2, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.64 (0.56, 0.7) 0.73 (0.73, 0.73) 0.51 (0.51, 0.51) 0.74 (0.6, 0.87) 0.55 (0.53, 0.61) 0.53 (0.53, 0.53) 0.53 (0.53, 0.53) 0.52 (0.52, 0.52) 0.52 (0.51, 0.53) NA (NA, NA) NA (NA, NA) 0.6 (0.6, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.57 (0.57, 0.57) NA (NA, NA) NA (NA, NA) 0.51 (0.51, 0.51) 0.54 (0.54, 0.54) NA (NA, NA) NA (NA, NA) 0.53 (0.52, 0.53) 0.55 (0.53, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0.062 (0.044, 0.076) 0 (0, 0) 0 (0, 0) 0 (0, 0.025) 0 (0, 0.025) 0.493 (0.188, 0.798) 0 (0, 0) 0.039 (0.008, 0.071) 0 (0, 0.03) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.139 (0.139, 0.139) NA (NA, NA) NA (NA, NA) 0 (0, 0.075) 0 (0, 0.238) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 13 13 13 13 13 13 13 13
AR- & TP53- TC1 time 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13)
AR- & TP53- TC1 n 15 (12, 21) 4 (3, 7) 0 (0, 2) 2 (0, 5) 3 (0, 5) 0 (0, 0) 1 (0, 4) 1 (0, 2)
AR- & TP53- TC1 post_p 0.76 (0.71, 0.83) 0.7 (0.57, 0.81) 0.57 (0.51, 0.6) 0.62 (0.55, 0.76) 0.62 (0.53, 0.73) NA (NA, NA) 0.58 (0.51, 0.66) 0.55 (0.52, 0.68)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.084 (0.057, 0.104) 0.059 (0.006, 0.097) 0 (0, 0.1) 0.024 (0, 0.084) 0 (0, 0.068) NA (NA, NA) 0 (0, 0.06) 0.064 (0, 0.3)
AR- & TP53- TC2 count 8 8 8 8 8 8 8 8
AR- & TP53- TC2 time 12 (10, 18) 12 (10, 18) 12 (10, 18) 12 (10, 18) 12 (10, 18) 12 (10, 18) 12 (10, 18) 12 (10, 18)
AR- & TP53- TC2 n 18 (15, 25) 4 (2, 6) 1 (0, 2) 1 (0, 7) 4 (2, 10) 0 (0, 0) 1 (1, 2) 0 (0, 1)
AR- & TP53- TC2 post_p 0.77 (0.74, 0.84) 0.61 (0.52, 0.75) 0.61 (0.57, 0.65) 0.58 (0.52, 0.7) 0.71 (0.55, 0.81) NA (NA, NA) 0.53 (0.52, 0.68) 0.56 (0.53, 0.58)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.077 (0.059, 0.094) 0.055 (0, 0.118) 0.049 (0, 0.436) 0.034 (0, 0.113) 0.044 (0, 0.062) NA (NA, NA) 0 (0, 0.026) 0 (0, 0)
AR- & TP53- TC3 count 65 65 65 65 65 65 65 65
AR- & TP53- TC3 time 14 (10, 26) 14 (10, 26) 14 (10, 26) 14 (10, 26) 14 (10, 26) 14 (10, 26) 14 (10, 26) 14 (10, 26)
AR- & TP53- TC3 n 19 (12, 40) 4 (2, 11) 1 (0, 2) 2 (0, 5) 5 (2, 10) 0 (0, 0) 2 (1, 5) 1 (0, 3)
AR- & TP53- TC3 post_p 0.79 (0.72, 0.93) 0.67 (0.52, 0.77) 0.57 (0.52, 0.67) 0.59 (0.51, 0.78) 0.77 (0.57, 0.97) NA (NA, NA) 0.6 (0.53, 0.84) 0.58 (0.53, 0.79)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.081 (0.053, 0.102) 0.078 (0, 0.136) 0 (0, 0.249) 0.055 (0, 0.137) 0.005 (0, 0.052) 0 (0, 0) 0 (0, 0.09) 0 (0, 0.046)
AR- & TP53- TC4 count 62 62 62 62 62 62 62 62
AR- & TP53- TC4 time 14 (9, 27) 14 (9, 27) 14 (9, 27) 14 (9, 27) 14 (9, 27) 14 (9, 27) 14 (9, 27) 14 (9, 27)
AR- & TP53- TC4 n 20 (15, 39) 5 (3, 12) 1 (0, 3) 2 (0, 5) 5 (1, 9) 0 (0, 0) 3 (0, 5) 1 (0, 3)
AR- & TP53- TC4 post_p 0.82 (0.72, 0.94) 0.66 (0.52, 0.82) 0.55 (0.52, 0.64) 0.58 (0.52, 0.78) 0.7 (0.54, 0.94) NA (NA, NA) 0.59 (0.53, 0.81) 0.56 (0.52, 0.68)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.072 (0.051, 0.1) 0.066 (0, 0.116) 0.063 (0, 0.222) 0.056 (0, 0.132) 0.02 (0, 0.08) NA (NA, NA) 0 (0, 0.083) 0 (0, 0.149)
AR- & TP53- TC5 count 10 10 10 10 10 10 10 10
AR- & TP53- TC5 time 14 (11, 17) 14 (11, 17) 14 (11, 17) 14 (11, 17) 14 (11, 17) 14 (11, 17) 14 (11, 17) 14 (11, 17)
AR- & TP53- TC5 n 20 (12, 23) 4 (4, 6) 0 (0, 1) 3 (2, 5) 2 (1, 4) 0 (0, 0) 2 (1, 4) 0 (0, 2)
AR- & TP53- TC5 post_p 0.78 (0.73, 0.87) 0.74 (0.53, 0.86) 0.61 (0.56, 0.69) 0.54 (0.51, 0.74) 0.57 (0.52, 0.62) NA (NA, NA) 0.6 (0.53, 0.63) 0.55 (0.54, 0.59)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.085 (0.026, 0.096) 0.071 (0.026, 0.102) 0 (0, 0.073) 0.082 (0, 0.114) 0 (0, 0.139) 1.141 (1.141, 1.141) 0 (0, 0.092) 0.067 (0, 0.307)
HRD+ TC1 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
HRD+ TC1 time 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
HRD+ TC1 n 11 (11, 11) 0 (0, 0) 3 (3, 3) 6 (6, 6) 0 (0, 0) 1 (1, 1) 0 (0, 0) 1 (1, 1) 3 (3, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.79 (0.79, 0.79) NA (NA, NA) 0.67 (0.67, 0.67) 0.77 (0.77, 0.77) NA (NA, NA) 0.58 (0.58, 0.58) NA (NA, NA) 0.89 (0.89, 0.89) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.057 (0.057, 0.057) NA (NA, NA) 0.066 (0.066, 0.066) 0.019 (0.019, 0.019) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.082 (0.082, 0.082) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC3 count 220 220 220 220 220 220 220 220 220 220 220 220 220 220 220 220
HRD+ TC3 time 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35)
HRD+ TC3 n 11 (8, 14) 0 (0, 0) 5 (3, 9) 2 (0, 4) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 4 (1, 6) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.95 (0.82, 1) 0.53 (0.51, 0.55) 0.83 (0.62, 0.96) 0.65 (0.53, 0.83) NA (NA, NA) 0.6 (0.52, 0.75) NA (NA, NA) 0.61 (0.52, 0.76) 0.75 (0.57, 0.93) 0.54 (0.54, 0.54) 0.56 (0.52, 0.62) NA (NA, NA) 0.54 (0.52, 0.59) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA)
HRD+ TC3 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.033 (0.017, 0.053) 0 (0, 2.172) 0.028 (0, 0.068) 0.024 (0, 0.075) 0.024 (0.005, 0.043) 0 (0, 0.083) 0 (0, 0.073) 0 (0, 0.103) 0.026 (0, 0.072) 0 (0, 0.102) 0 (0, 0.105) 0 (0, 0.482) 0 (0, 0.173) 0.087 (0.017, 0.156) 0.058 (0, 0.143) 0 (0, 0.264)
HRD+ TC4 count 219 219 219 219 219 219 219 219 219 219 219 219 219 219 219 219
HRD+ TC4 time 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35) 30 (24, 35)
HRD+ TC4 n 11 (8, 16) 0 (0, 0) 5 (3, 9) 2 (1, 5) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 3 (1, 6) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.96 (0.76, 1) 0.56 (0.55, 0.58) 0.82 (0.62, 0.96) 0.68 (0.54, 0.84) NA (NA, NA) 0.6 (0.52, 0.79) 0.6 (0.6, 0.6) 0.6 (0.52, 0.79) 0.71 (0.56, 0.89) 0.67 (0.67, 0.67) 0.58 (0.51, 0.64) NA (NA, NA) 0.56 (0.52, 0.58) NA (NA, NA) NA (NA, NA) 0.52 (0.52, 0.52)
HRD+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.033 (0.014, 0.058) 0 (0, 0.013) 0.031 (0, 0.069) 0.02 (0, 0.072) 0 (0, 0) 0 (0, 0.071) 0 (0, 0.456) 0 (0, 0.095) 0.028 (0, 0.076) 0.027 (0, 0.18) 0 (0, 0.094) 0 (0, 0.388) 0 (0, 0.82) 0.166 (0.033, 0.299) 0.081 (0.016, 0.109) 0 (0, 0.101)
TP53+ TC1 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
TP53+ TC1 time 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22)
TP53+ TC1 n 5 (5, 7) 8 (4, 10) 0 (0, 2) 5 (3, 5) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 6 (4, 7) 4 (3, 6) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.71 (0.6, 0.81) 0.8 (0.7, 0.87) 0.58 (0.52, 0.65) 0.56 (0.51, 0.69) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.68 (0.56, 0.82) 0.72 (0.54, 0.87) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.088 (0.069, 0.108) 0.074 (0.05, 0.076) 0.035 (0.007, 0.064) 0.079 (0.035, 0.129) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.062 (0.035, 0.1) 0.066 (0.013, 0.113) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
TP53+ TC2 time 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26)
TP53+ TC2 n 6 (6, 7) 4 (4, 5) 1 (1, 1) 4 (4, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (0, 2) 0 (0, 0) 4 (4, 5) 5 (5, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.78 (0.76, 0.79) 0.68 (0.54, 0.81) 0.67 (0.57, 0.76) 0.58 (0.53, 0.62) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.57 (0.57, 0.57) NA (NA, NA) 0.8 (0.79, 0.81) 0.61 (0.54, 0.68) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.069 (0.062, 0.076) 0.073 (0.034, 0.112) 0 (0, 0) 0.119 (0.118, 0.12) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.137 (0.137, 0.137) NA (NA, NA) 0.061 (0.034, 0.088) 0.074 (0.062, 0.086) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
TP53+ TC3 time 21 (16, 24) 21 (16, 24) 21 (16, 24) 21 (16, 24) 21 (16, 24) 21 (16, 24) 21 (16, 24) 21 (16, 24) 21 (16, 24) 21 (16, 24) 21 (16, 24) 21 (16, 24) 21 (16, 24) 21 (16, 24) 21 (16, 24) 21 (16, 24)
TP53+ TC3 n 8 (4, 11) 6 (5, 8) 2 (0, 4) 4 (2, 6) 0 (0, 0) 0 (0, 1) 0 (0, 0) 1 (0, 2) 1 (0, 2) 0 (0, 0) 4 (4, 6) 4 (2, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.77 (0.68, 0.82) 0.79 (0.73, 0.88) 0.54 (0.52, 0.63) 0.7 (0.6, 0.77) NA (NA, NA) 0.63 (0.58, 0.64) NA (NA, NA) 0.63 (0.6, 0.68) 0.59 (0.59, 0.59) NA (NA, NA) 0.69 (0.56, 0.78) 0.61 (0.54, 0.72) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.081 (0.04, 0.099) 0.053 (0.039, 0.07) 0.106 (0.026, 0.128) 0.026 (0, 0.091) 0 (0, 0) 0 (0, 0.069) NA (NA, NA) 0 (0, 0.053) 0.085 (0, 0.228) NA (NA, NA) 0.07 (0.039, 0.096) 0.058 (0.043, 0.111) 0.173 (0.173, 0.173) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
TP53+ TC4 time 22 (17, 31) 22 (17, 31) 22 (17, 31) 22 (17, 31) 22 (17, 31) 22 (17, 31) 22 (17, 31) 22 (17, 31) 22 (17, 31) 22 (17, 31) 22 (17, 31) 22 (17, 31) 22 (17, 31) 22 (17, 31) 22 (17, 31) 22 (17, 31)
TP53+ TC4 n 8 (4, 15) 8 (6, 9) 2 (1, 4) 5 (4, 6) 0 (0, 0) 0 (0, 2) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 0) 5 (3, 8) 2 (2, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1)
TP53+ TC4 post_p 0.75 (0.64, 0.89) 0.85 (0.8, 0.93) 0.59 (0.55, 0.68) 0.71 (0.55, 0.83) NA (NA, NA) 0.56 (0.52, 0.61) NA (NA, NA) 0.6 (0.6, 0.6) 0.54 (0.52, 0.56) NA (NA, NA) 0.66 (0.58, 0.77) 0.77 (0.64, 0.91) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.07 (0.063, 0.09) 0.055 (0.035, 0.088) 0.023 (0, 0.073) 0.086 (0.074, 0.115) NA (NA, NA) 0.121 (0.024, 0.217) NA (NA, NA) 0 (0, 0.039) 0.079 (0.065, 0.093) NA (NA, NA) 0.078 (0.051, 0.098) 0.044 (0.035, 0.053) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.092 (0.092, 0.092)
TP53+ TC5 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TP53+ TC5 time 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24) 18 (16, 24)
TP53+ TC5 n 9 (7, 12) 6 (5, 8) 2 (1, 2) 3 (2, 8) 0 (0, 0) 1 (0, 1) 0 (0, 0) 1 (0, 1) 0 (0, 0) 0 (0, 0) 5 (3, 6) 3 (1, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.78 (0.72, 0.85) 0.74 (0.55, 0.77) 0.58 (0.52, 0.61) 0.81 (0.76, 0.82) NA (NA, NA) 0.6 (0.6, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.8 (0.62, 0.84) 0.59 (0.57, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.059 (0.038, 0.064) 0.098 (0.066, 0.112) 0.083 (0.017, 0.179) 0.047 (0.009, 0.075) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0.063 (0.048, 0.109) 0.101 (0.02, 0.117) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
TEfus+ TC1 time 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21) 20 (20, 21)
TEfus+ TC1 n 2 (0, 3) 3 (2, 4) 2 (0, 3) 6 (5, 6) 4 (3, 5) 0 (0, 0) 0 (0, 1) 0 (0, 1) 2 (1, 4) 2 (1, 2) 3 (3, 3) 5 (4, 6) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.69 (0.69, 0.69) 0.62 (0.53, 0.71) 0.63 (0.63, 0.63) 0.74 (0.71, 0.77) 0.71 (0.67, 0.75) NA (NA, NA) NA (NA, NA) 0.51 (0.51, 0.51) 0.81 (0.73, 0.9) 0.6 (0.56, 0.65) 0.66 (0.56, 0.76) 0.72 (0.69, 0.75) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.07 (0.07, 0.07) 0.115 (0.075, 0.154) 0.082 (0.082, 0.082) 0.055 (0.053, 0.056) 0.052 (0.049, 0.054) NA (NA, NA) 0.646 (0.646, 0.646) 0.111 (0.111, 0.111) 0.066 (0.027, 0.105) 0 (0, 0) 0.081 (0.039, 0.122) 0.04 (0.032, 0.048) 0.159 (0.159, 0.159) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
TEfus+ TC3 time 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32) 22 (15, 32)
TEfus+ TC3 n 1 (0, 3) 4 (3, 5) 3 (1, 3) 5 (2, 8) 4 (1, 6) 2 (0, 4) 0 (0, 0) 0 (0, 2) 2 (2, 4) 1 (1, 2) 7 (3, 12) 4 (3, 8) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.6 (0.54, 0.8) 0.7 (0.53, 0.76) 0.66 (0.54, 0.79) 0.78 (0.64, 0.89) 0.73 (0.67, 0.94) 0.69 (0.62, 0.84) NA (NA, NA) 0.54 (0.54, 0.54) 0.6 (0.52, 0.68) 0.59 (0.59, 0.65) 0.71 (0.53, 0.82) 0.74 (0.63, 0.82) 0.58 (0.57, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.058 (0.017, 0.127) 0.071 (0.046, 0.106) 0.017 (0, 0.063) 0.062 (0.025, 0.078) 0.023 (0, 0.041) 0 (0, 0.018) 0.041 (0.041, 0.041) 0.048 (0.01, 0.086) 0.065 (0.017, 0.156) 0 (0, 0.092) 0.077 (0.046, 0.126) 0.051 (0, 0.072) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TEfus+ TC4 time 19 (16, 25) 19 (16, 25) 19 (16, 25) 19 (16, 25) 19 (16, 25) 19 (16, 25) 19 (16, 25) 19 (16, 25) 19 (16, 25) 19 (16, 25) 19 (16, 25) 19 (16, 25) 19 (16, 25) 19 (16, 25) 19 (16, 25) 19 (16, 25)
TEfus+ TC4 n 1 (0, 1) 4 (2, 5) 2 (0, 2) 4 (2, 5) 2 (2, 4) 1 (0, 3) 0 (0, 0) 0 (0, 1) 3 (1, 4) 0 (0, 2) 7 (5, 9) 3 (3, 4) 1 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.53 (0.53, 0.53) 0.74 (0.57, 0.77) 0.53 (0.51, 0.56) 0.77 (0.69, 0.78) 0.67 (0.54, 0.92) 0.58 (0.57, 0.59) NA (NA, NA) 0.54 (0.54, 0.54) 0.62 (0.53, 0.71) NA (NA, NA) 0.72 (0.56, 0.76) 0.59 (0.54, 0.77) 0.57 (0.57, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0 (0, 0) 0.088 (0.018, 0.095) 0.089 (0.018, 0.16) 0 (0, 0.031) 0 (0, 0.043) 0.009 (0.002, 0.016) NA (NA, NA) 0 (0, 0) 0.083 (0.05, 0.116) 0.118 (0.118, 0.118) 0.094 (0.094, 0.101) 0.055 (0.048, 0.062) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
PI3K+ TC1 time 20 (18, 22) 20 (18, 22) 20 (18, 22) 20 (18, 22) 20 (18, 22) 20 (18, 22) 20 (18, 22) 20 (18, 22) 20 (18, 22) 20 (18, 22) 20 (18, 22) 20 (18, 22) 20 (18, 22) 20 (18, 22) 20 (18, 22) 20 (18, 22)
PI3K+ TC1 n 8 (4, 11) 4 (3, 5) 4 (3, 5) 4 (4, 4) 0 (0, 0) 4 (3, 4) 2 (1, 2) 2 (1, 3) 2 (2, 2) 1 (1, 1) 0 (0, 0) 2 (1, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.79 (0.78, 0.79) 0.55 (0.55, 0.55) 0.87 (0.86, 0.87) 0.66 (0.6, 0.72) NA (NA, NA) 0.53 (0.51, 0.56) 0.52 (0.52, 0.52) NA (NA, NA) 0.6 (0.6, 0.6) 0.58 (0.54, 0.61) NA (NA, NA) 0.69 (0.57, 0.8) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.045 (0.037, 0.054) 0.087 (0.085, 0.089) 0 (0, 0) 0.088 (0.064, 0.113) NA (NA, NA) 0.056 (0.029, 0.083) 0.102 (0.02, 0.184) 0.244 (0.239, 0.25) 0.861 (0.245, 1.476) 0.031 (0.006, 0.057) NA (NA, NA) 0.041 (0.008, 0.074) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
PI3K+ TC2 time 20 (16, 24) 20 (16, 24) 20 (16, 24) 20 (16, 24) 20 (16, 24) 20 (16, 24) 20 (16, 24) 20 (16, 24) 20 (16, 24) 20 (16, 24) 20 (16, 24) 20 (16, 24) 20 (16, 24) 20 (16, 24) 20 (16, 24) 20 (16, 24)
PI3K+ TC2 n 9 (8, 10) 5 (3, 7) 4 (3, 6) 4 (4, 4) 0 (0, 0) 2 (2, 3) 0 (0, 0) 1 (0, 2) 1 (1, 2) 1 (0, 3) 0 (0, 0) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1)
PI3K+ TC2 post_p 0.75 (0.72, 0.81) 0.57 (0.57, 0.75) 0.73 (0.57, 0.84) 0.56 (0.51, 0.8) NA (NA, NA) 0.6 (0.54, 0.66) NA (NA, NA) 0.62 (0.53, 0.71) 0.66 (0.58, 0.73) 0.52 (0.52, 0.54) NA (NA, NA) 0.66 (0.65, 0.82) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.057 (0.049, 0.063) 0.097 (0.063, 0.117) 0.043 (0.009, 0.085) 0.095 (0.054, 0.102) NA (NA, NA) 0 (0, 0.208) NA (NA, NA) 0.228 (0.137, 0.318) 0 (0, 0.032) 0.081 (0.016, 0.146) NA (NA, NA) 0.042 (0.008, 0.047) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0)
PI3K+ TC3 count 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
PI3K+ TC3 time 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28) 22 (13, 28)
PI3K+ TC3 n 6 (4, 9) 4 (3, 6) 7 (5, 8) 4 (3, 6) 0 (0, 0) 1 (0, 3) 1 (0, 2) 0 (0, 2) 0 (0, 1) 1 (1, 2) 0 (0, 0) 3 (2, 6) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.73 (0.54, 0.87) 0.64 (0.59, 0.71) 0.76 (0.68, 0.86) 0.76 (0.63, 0.85) NA (NA, NA) 0.6 (0.55, 0.69) 0.6 (0.57, 0.67) 0.67 (0.64, 0.71) 0.56 (0.54, 0.58) 0.57 (0.53, 0.72) NA (NA, NA) 0.69 (0.61, 0.83) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.064 (0.032, 0.11) 0.055 (0.032, 0.091) 0.066 (0.033, 0.104) 0.054 (0.047, 0.074) 0 (0, 0) 0 (0, 0.06) 0 (0, 0.035) 0 (0, 0.067) 0.025 (0, 0.055) 0 (0, 0.081) NA (NA, NA) 0.053 (0, 0.099) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
PI3K+ TC4 time 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22) 18 (16, 22)
PI3K+ TC4 n 5 (4, 8) 4 (2, 5) 6 (4, 8) 4 (2, 5) 0 (0, 0) 2 (2, 4) 0 (0, 2) 0 (0, 1) 1 (0, 1) 0 (0, 2) 0 (0, 0) 4 (2, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.66 (0.52, 0.85) 0.64 (0.53, 0.71) 0.65 (0.55, 0.75) 0.59 (0.54, 0.7) NA (NA, NA) 0.54 (0.51, 0.77) 0.6 (0.58, 0.69) 0.58 (0.58, 0.58) 0.53 (0.51, 0.54) 0.57 (0.57, 0.57) NA (NA, NA) 0.7 (0.54, 0.89) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.074 (0.053, 0.119) 0.074 (0.023, 0.096) 0.08 (0.063, 0.088) 0.08 (0, 0.103) NA (NA, NA) 0.033 (0.028, 0.126) 0 (0, 0.129) 0 (0, 0) 0 (0, 0) 0.245 (0.13, 0.359) NA (NA, NA) 0.053 (0.01, 0.095) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA)
PI3K+ TC5 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
PI3K+ TC5 time 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23)
PI3K+ TC5 n 5 (5, 5) 5 (5, 5) 7 (7, 7) 7 (7, 7) 0 (0, 0) 2 (2, 2) 1 (1, 1) 0 (0, 0) 1 (1, 1) 1 (1, 1) 0 (0, 0) 3 (3, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.51 (0.51, 0.51) 0.84 (0.84, 0.84) 0.83 (0.83, 0.83) 0.87 (0.87, 0.87) NA (NA, NA) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) 0.6 (0.6, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.137 (0.137, 0.137) 0.047 (0.047, 0.047) 0.051 (0.051, 0.051) 0.069 (0.069, 0.069) NA (NA, NA) 0.098 (0.098, 0.098) 0.15 (0.15, 0.15) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.067 (0.067, 0.067) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Futility:
signature treatment var —– —-+ —+- —++ –+– –+-+ –++- –+++ -+— -+–+ -+-+- -+-++ -++– -++-+ -+++- -++++ +—- +—+ +–+- +–++ +-+– +-+-+ +-++- +-+++ ++— ++–+ ++-+- ++-++ +++– +++-+ ++++- +++++
all TC2 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
all TC2 time 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14) 8 (6, 14)
all TC2 n 11 (8, 14) 3 (2, 3) 0 (0, 2) 2 (0, 3) 2 (0, 6) 3 (2, 4) 1 (1, 2) 2 (1, 2) 3 (1, 5) 0 (0, 1) 2 (0, 6) 1 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 2) 1 (0, 3) 0 (0, 1) 2 (0, 2) 0 (0, 1) 0 (0, 2) 0 (0, 0) 4 (2, 6) 1 (0, 2) 1 (0, 3) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.4 (0.25, 0.47) 0.39 (0.36, 0.4) NA (NA, NA) 0.25 (0.21, 0.28) 0.27 (0.2, 0.33) 0.41 (0.34, 0.46) 0.4 (0.31, 0.46) 0.39 (0.36, 0.45) 0.34 (0.34, 0.34) NA (NA, NA) 0.37 (0.32, 0.42) NA (NA, NA) NA (NA, NA) 0.43 (0.43, 0.43) NA (NA, NA) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) NA (NA, NA) 0.46 (0.46, 0.46) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.44 (0.28, 0.48) 0.49 (0.49, 0.49) 0.48 (0.47, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.133 (0.12, 0.147) 0.293 (0.238, 0.344) 0.969 (0.969, 0.969) 0.507 (0.34, 0.673) 0.313 (0.239, 0.386) 0.114 (0.105, 0.403) 0.439 (0.431, 0.503) 0.153 (0.131, 0.471) 0.192 (0.128, 0.257) 0 (0, 0) 0.157 (0.137, 0.177) 0 (0, 0) NA (NA, NA) 1.537 (1.537, 1.537) NA (NA, NA) 0.432 (0.432, 0.432) 0.068 (0.014, 0.123) 0 (0, 0) 0.251 (0.05, 0.451) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.247 (0.183, 0.283) 0.264 (0.246, 0.282) 0.039 (0.008, 0.071) NA (NA, NA) 0.165 (0.163, 0.167) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
all TC5 time 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14)
all TC5 n 13 (4, 15) 4 (3, 6) 1 (0, 2) 1 (0, 4) 7 (2, 11) 4 (2, 7) 0 (0, 1) 2 (1, 4) 4 (3, 5) 0 (0, 0) 1 (0, 3) 1 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 2) 0 (0, 2) 0 (0, 1) 0 (0, 1) 4 (1, 5) 2 (1, 3) 1 (0, 2) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 post_p 0.25 (0.06, 0.46) 0.38 (0.29, 0.4) 0.31 (0.31, 0.31) 0.4 (0.34, 0.45) 0.46 (0.41, 0.48) 0.23 (0.13, 0.39) 0.43 (0.42, 0.43) 0.34 (0.26, 0.45) 0.43 (0.3, 0.48) NA (NA, NA) 0.45 (0.36, 0.48) 0.47 (0.47, 0.47) NA (NA, NA) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.5 (0.5, 0.5) 0.38 (0.38, 0.38) NA (NA, NA) NA (NA, NA) 0.38 (0.33, 0.41) 0.42 (0.36, 0.48) 0.44 (0.44, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC5 rate 0.176 (0.129, 0.221) 0.208 (0.128, 0.253) 0.286 (0.2, 0.582) 0.365 (0.121, 0.811) 0.089 (0.059, 0.123) 0.222 (0.121, 0.393) 0.525 (0.221, 0.83) 0.33 (0.195, 0.513) 0.129 (0.118, 0.345) NA (NA, NA) 0.187 (0.037, 0.204) 0 (0, 0.17) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0.166 (0.157, 0.176) NA (NA, NA) 0 (0, 0) 0.296 (0.153, 0.439) 0.221 (0.221, 0.221) 0.068 (0.068, 0.068) 0.209 (0.124, 0.282) 0.17 (0.104, 0.453) 0.119 (0.116, 0.397) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
AR- & TP53- TC1 count 77 77 77 77 77 77 77 77
AR- & TP53- TC1 time 15 (9, 32) 15 (9, 32) 15 (9, 32) 15 (9, 32) 15 (9, 32) 15 (9, 32) 15 (9, 32) 15 (9, 32)
AR- & TP53- TC1 n 21 (14, 47) 6 (3, 13) 1 (0, 3) 3 (0, 7) 6 (3, 11) 0 (0, 0) 3 (1, 5) 1 (0, 3)
AR- & TP53- TC1 post_p 0.34 (0.13, 0.47) 0.4 (0.22, 0.48) 0.43 (0.35, 0.48) 0.41 (0.24, 0.48) 0.38 (0.14, 0.48) NA (NA, NA) 0.41 (0.23, 0.49) 0.43 (0.33, 0.48)
AR- & TP53- TC1 r_prob 0.41 (0.41, 0.41) 0.22 (0.22, 0.22) 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC1 rate 0.124 (0.106, 0.166) 0.15 (0.103, 0.266) 0.282 (0.093, 0.961) 0.174 (0.112, 0.363) 0.146 (0.082, 0.261) 0.119 (0.119, 0.119) 0.165 (0.09, 0.407) 0.143 (0.012, 0.601)
AR- & TP53- TC2 count 94 94 94 94 94 94 94 94
AR- & TP53- TC2 time 15 (9, 30) 15 (9, 30) 15 (9, 30) 15 (9, 30) 15 (9, 30) 15 (9, 30) 15 (9, 30) 15 (9, 30)
AR- & TP53- TC2 n 19 (14, 44) 5 (2, 13) 1 (0, 3) 3 (0, 7) 5 (2, 10) 0 (0, 0) 2 (0, 7) 1 (0, 3)
AR- & TP53- TC2 post_p 0.31 (0.1, 0.45) 0.39 (0.23, 0.47) 0.44 (0.37, 0.5) 0.41 (0.26, 0.49) 0.38 (0.16, 0.48) NA (NA, NA) 0.41 (0.23, 0.49) 0.41 (0.32, 0.47)
AR- & TP53- TC2 r_prob 0.18 (0.18, 0.18) 0.03 (0.03, 0.03) 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC2 rate 0.133 (0.112, 0.172) 0.152 (0.099, 0.304) 0.186 (0.08, 0.588) 0.189 (0.102, 0.511) 0.132 (0.084, 0.349) NA (NA, NA) 0.161 (0.081, 0.458) 0.209 (0.035, 0.702)
AR- & TP53- TC3 count 4 4 4 4 4 4 4 4
AR- & TP53- TC3 time 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11)
AR- & TP53- TC3 n 14 (11, 18) 4 (4, 6) 0 (0, 1) 3 (2, 4) 3 (2, 4) 0 (0, 0) 2 (1, 4) 0 (0, 2)
AR- & TP53- TC3 post_p 0.31 (0.27, 0.34) 0.22 (0.14, 0.31) NA (NA, NA) 0.44 (0.39, 0.49) 0.46 (0.38, 0.49) NA (NA, NA) 0.41 (0.34, 0.48) NA (NA, NA)
AR- & TP53- TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC3 rate 0.119 (0.107, 0.137) 0.321 (0.227, 0.498) 0 (0, 0) 0.143 (0.126, 0.165) 0.141 (0.078, 0.544) NA (NA, NA) 0.128 (0.085, 1.444) 0 (0, 0)
AR- & TP53- TC4 count 10 10 10 10 10 10 10 10
AR- & TP53- TC4 time 12 (9, 16) 12 (9, 16) 12 (9, 16) 12 (9, 16) 12 (9, 16) 12 (9, 16) 12 (9, 16) 12 (9, 16)
AR- & TP53- TC4 n 18 (11, 20) 4 (2, 8) 0 (0, 3) 1 (1, 5) 3 (2, 6) 0 (0, 0) 2 (0, 4) 1 (0, 2)
AR- & TP53- TC4 post_p 0.37 (0.17, 0.45) 0.36 (0.16, 0.44) 0.47 (0.45, 0.49) 0.41 (0.36, 0.46) 0.45 (0.42, 0.48) NA (NA, NA) 0.43 (0.38, 0.46) 0.42 (0.41, 0.45)
AR- & TP53- TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
AR- & TP53- TC4 rate 0.127 (0.111, 0.236) 0.176 (0.149, 0.343) 0.262 (0.067, 0.637) 0.277 (0.114, 2.013) 0.14 (0.09, 0.176) NA (NA, NA) 0.135 (0.081, 0.193) 0.157 (0, 0.256)
AR- & TP53- TC5 count 79 79 79 79 79 79 79 79
AR- & TP53- TC5 time 15 (10, 33) 15 (10, 33) 15 (10, 33) 15 (10, 33) 15 (10, 33) 15 (10, 33) 15 (10, 33) 15 (10, 33)
AR- & TP53- TC5 n 23 (14, 47) 6 (2, 14) 1 (0, 3) 3 (1, 7) 6 (2, 12) 0 (0, 0) 2 (0, 7) 1 (0, 4)
AR- & TP53- TC5 post_p 0.3 (0.08, 0.47) 0.35 (0.19, 0.47) 0.43 (0.34, 0.49) 0.4 (0.24, 0.48) 0.33 (0.18, 0.48) NA (NA, NA) 0.39 (0.23, 0.48) 0.42 (0.36, 0.47)
AR- & TP53- TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
AR- & TP53- TC5 rate 0.13 (0.105, 0.165) 0.153 (0.1, 0.311) 0.183 (0.085, 0.405) 0.179 (0.107, 0.43) 0.145 (0.084, 0.376) 0.355 (0.355, 0.355) 0.16 (0.077, 0.269) 0.204 (0.06, 0.888)
HRD+ TC1 count 61 61 61 61 61 61 61 61 61 61 61 61 61 61 61 61
HRD+ TC1 time 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35)
HRD+ TC1 n 11 (8, 17) 0 (0, 0) 6 (3, 9) 3 (1, 5) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 3 (2, 6) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.24 (0.1, 0.47) NA (NA, NA) 0.34 (0.15, 0.46) 0.42 (0.28, 0.49) 0.5 (0.5, 0.5) 0.42 (0.34, 0.48) NA (NA, NA) 0.4 (0.36, 0.48) 0.37 (0.2, 0.47) NA (NA, NA) 0.43 (0.42, 0.48) NA (NA, NA) 0.47 (0.47, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.13 (0.096, 0.182) 0.651 (0.651, 0.651) 0.15 (0.104, 0.277) 0.166 (0.056, 0.557) 0.199 (0.157, 0.24) 0.189 (0.067, 0.853) 0.747 (0.747, 0.747) 0.191 (0.083, 0.483) 0.146 (0.077, 0.32) 0.166 (0.166, 0.166) 0.207 (0.068, 0.742) 0.087 (0.017, 0.156) 0.239 (0, 4.669) 0.13 (0.13, 0.13) 0.139 (0.065, 0.282) NA (NA, NA)
HRD+ TC2 count 67 67 67 67 67 67 67 67 67 67 67 67 67 67 67 67
HRD+ TC2 time 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35) 31 (24, 35)
HRD+ TC2 n 12 (8, 14) 0 (0, 0) 6 (2, 9) 2 (1, 4) 0 (0, 0) 1 (0, 3) 0 (0, 0) 2 (0, 3) 4 (2, 6) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.22 (0.05, 0.42) NA (NA, NA) 0.32 (0.16, 0.45) 0.42 (0.27, 0.48) 0.45 (0.45, 0.45) 0.42 (0.28, 0.49) NA (NA, NA) 0.42 (0.31, 0.47) 0.35 (0.17, 0.49) NA (NA, NA) 0.43 (0.38, 0.48) NA (NA, NA) 0.46 (0.44, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.133 (0.097, 0.205) 0.077 (0.077, 0.077) 0.146 (0.097, 0.26) 0.152 (0.08, 0.845) 0.368 (0.319, 0.417) 0.172 (0.085, 0.579) 0.268 (0.096, 0.44) 0.159 (0.062, 0.433) 0.132 (0.088, 0.381) 0.158 (0.158, 0.158) 0.225 (0.051, 0.516) 0.055 (0.011, 0.1) 0.154 (0, 1.883) 0.072 (0.014, 0.13) 0.098 (0.083, 0.117) 0.169 (0.107, 0.231)
HRD+ TC5 count 74 74 74 74 74 74 74 74 74 74 74 74 74 74 74 74
HRD+ TC5 time 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35)
HRD+ TC5 n 12 (9, 15) 0 (0, 0) 5 (3, 9) 3 (0, 4) 0 (0, 0) 1 (0, 3) 0 (0, 0) 1 (0, 3) 4 (2, 6) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 post_p 0.23 (0.09, 0.42) NA (NA, NA) 0.38 (0.19, 0.47) 0.41 (0.29, 0.48) NA (NA, NA) 0.41 (0.33, 0.47) NA (NA, NA) 0.44 (0.29, 0.48) 0.35 (0.21, 0.48) NA (NA, NA) 0.44 (0.41, 0.49) NA (NA, NA) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA)
HRD+ TC5 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC5 rate 0.129 (0.096, 0.183) 5.755 (1.343, 9.428) 0.131 (0.089, 0.22) 0.133 (0.078, 0.691) 0.21 (0.042, 0.413) 0.186 (0.071, 0.95) 0 (0, 0.134) 0.164 (0.068, 0.493) 0.154 (0.083, 0.345) 0.197 (0.167, 0.22) 0.122 (0, 1.938) 0.106 (0.106, 0.106) 0.151 (0.047, 0.395) 0.051 (0.01, 0.102) NA (NA, NA) 0.081 (0.06, 0.103)
TP53+ TC1 count 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30
TP53+ TC1 time 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32)
TP53+ TC1 n 6 (4, 12) 7 (4, 11) 2 (0, 4) 5 (2, 9) 0 (0, 0) 0 (0, 3) 0 (0, 0) 1 (0, 2) 0 (0, 1) 0 (0, 0) 5 (4, 8) 4 (2, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.24 (0.17, 0.41) 0.35 (0.22, 0.49) 0.41 (0.27, 0.46) 0.4 (0.23, 0.47) 0.46 (0.46, 0.46) 0.41 (0.27, 0.46) NA (NA, NA) 0.42 (0.33, 0.48) 0.45 (0.4, 0.47) NA (NA, NA) 0.39 (0.16, 0.49) 0.43 (0.2, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.31 (0.31, 0.31) 0.13 (0.13, 0.13) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.179 (0.129, 0.332) 0.151 (0.096, 0.266) 0.233 (0.103, 0.551) 0.143 (0.114, 0.252) 0.238 (0.165, 0.312) 0.182 (0.061, 0.295) NA (NA, NA) 0.155 (0.036, 0.364) 0.234 (0.082, 3.127) 0.212 (0.212, 0.212) 0.15 (0.107, 0.243) 0.146 (0.098, 0.394) 0.153 (0.031, 0.625) 0.288 (0.288, 0.288) NA (NA, NA) 0 (0, 0)
TP53+ TC2 count 36 36 36 36 36 36 36 36 36 36 36 36 36 36 36 36
TP53+ TC2 time 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32) 22 (14, 32)
TP53+ TC2 n 7 (4, 12) 6 (4, 10) 2 (0, 5) 5 (2, 10) 0 (0, 0) 1 (0, 2) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 0) 6 (4, 10) 5 (2, 9) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.27 (0.1, 0.44) 0.4 (0.15, 0.48) 0.4 (0.28, 0.47) 0.37 (0.2, 0.49) NA (NA, NA) 0.43 (0.32, 0.49) NA (NA, NA) 0.43 (0.32, 0.49) 0.44 (0.4, 0.46) NA (NA, NA) 0.35 (0.13, 0.48) 0.35 (0.15, 0.47) 0.46 (0.46, 0.46) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA)
TP53+ TC2 r_prob 0.17 (0.17, 0.17) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.169 (0.125, 0.251) 0.149 (0.104, 0.232) 0.24 (0.095, 0.482) 0.141 (0.097, 0.437) 2.968 (2.968, 2.968) 0.188 (0.029, 0.833) NA (NA, NA) 0.193 (0, 0.53) 0.226 (0.112, 1.173) NA (NA, NA) 0.157 (0.121, 0.228) 0.171 (0.117, 0.369) 0.249 (0.149, 0.36) 0.144 (0.144, 0.144) 0.08 (0.078, 1.011) NA (NA, NA)
TP53+ TC3 count 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14
TP53+ TC3 time 24 (13, 33) 24 (13, 33) 24 (13, 33) 24 (13, 33) 24 (13, 33) 24 (13, 33) 24 (13, 33) 24 (13, 33) 24 (13, 33) 24 (13, 33) 24 (13, 33) 24 (13, 33) 24 (13, 33) 24 (13, 33) 24 (13, 33) 24 (13, 33)
TP53+ TC3 n 9 (5, 14) 6 (4, 11) 2 (0, 3) 4 (2, 11) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 3) 0 (0, 2) 0 (0, 0) 4 (4, 10) 4 (1, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.44 (0.21, 0.48) 0.33 (0.14, 0.48) 0.37 (0.28, 0.48) 0.35 (0.1, 0.39) NA (NA, NA) 0.41 (0.37, 0.46) NA (NA, NA) 0.45 (0.43, 0.46) 0.42 (0.41, 0.47) NA (NA, NA) 0.32 (0.21, 0.43) 0.36 (0.21, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.135 (0.114, 0.179) 0.166 (0.104, 0.295) 0.231 (0.135, 4.249) 0.19 (0.142, 0.438) NA (NA, NA) 0.171 (0.094, 3.996) NA (NA, NA) 0.1 (0.088, 2.893) 0.313 (0.093, 0.445) NA (NA, NA) 0.19 (0.138, 0.328) 0.168 (0.117, 0.365) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA)
TP53+ TC4 count 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11
TP53+ TC4 time 20 (14, 29) 20 (14, 29) 20 (14, 29) 20 (14, 29) 20 (14, 29) 20 (14, 29) 20 (14, 29) 20 (14, 29) 20 (14, 29) 20 (14, 29) 20 (14, 29) 20 (14, 29) 20 (14, 29) 20 (14, 29) 20 (14, 29) 20 (14, 29)
TP53+ TC4 n 7 (3, 8) 8 (4, 13) 2 (1, 3) 6 (4, 10) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 6 (3, 10) 3 (1, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1)
TP53+ TC4 post_p 0.44 (0.25, 0.48) 0.29 (0.23, 0.48) 0.36 (0.34, 0.47) 0.34 (0.27, 0.48) NA (NA, NA) 0.46 (0.42, 0.48) NA (NA, NA) 0.43 (0.43, 0.43) 0.47 (0.47, 0.47) NA (NA, NA) 0.32 (0.16, 0.41) 0.37 (0.17, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.43 (0.43, 0.43)
TP53+ TC4 r_prob 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.141 (0.102, 0.228) 0.152 (0.131, 0.177) 0.174 (0.073, 0.294) 0.137 (0.109, 0.262) NA (NA, NA) 0.199 (0.079, 0.387) NA (NA, NA) 0.103 (0.015, 0.229) 0.142 (0.093, 3.857) NA (NA, NA) 0.177 (0.124, 0.211) 0.162 (0.114, 0.52) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0.326 (0.065, 0.586)
TP53+ TC5 count 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30
TP53+ TC5 time 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32)
TP53+ TC5 n 7 (5, 12) 7 (4, 10) 2 (0, 4) 5 (2, 10) 0 (0, 0) 1 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 1) 0 (0, 0) 6 (3, 8) 4 (1, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 post_p 0.35 (0.11, 0.44) 0.33 (0.13, 0.49) 0.42 (0.25, 0.48) 0.36 (0.24, 0.49) NA (NA, NA) 0.42 (0.37, 0.47) NA (NA, NA) 0.44 (0.34, 0.49) 0.48 (0.39, 0.48) NA (NA, NA) 0.34 (0.21, 0.48) 0.4 (0.21, 0.49) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53+ TC5 r_prob 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC5 rate 0.143 (0.102, 0.274) 0.18 (0.109, 0.262) 0.181 (0.106, 0.538) 0.163 (0.107, 0.312) 0.091 (0.018, 0.164) 0.194 (0.099, 1.132) NA (NA, NA) 0.167 (0.011, 0.32) 0.249 (0.077, 0.887) 0.234 (0.102, 0.367) 0.172 (0.102, 0.291) 0.162 (0.096, 0.29) 0.174 (0.14, 0.207) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 count 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
TEfus+ TC1 time 23 (16, 31) 23 (16, 31) 23 (16, 31) 23 (16, 31) 23 (16, 31) 23 (16, 31) 23 (16, 31) 23 (16, 31) 23 (16, 31) 23 (16, 31) 23 (16, 31) 23 (16, 31) 23 (16, 31) 23 (16, 31) 23 (16, 31) 23 (16, 31)
TEfus+ TC1 n 0 (0, 3) 4 (2, 6) 2 (1, 4) 6 (4, 8) 4 (2, 6) 2 (1, 2) 0 (0, 0) 1 (0, 2) 3 (2, 4) 1 (0, 2) 5 (3, 10) 4 (3, 5) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.44 (0.43, 0.46) 0.44 (0.26, 0.48) 0.42 (0.32, 0.47) 0.29 (0.18, 0.45) 0.41 (0.32, 0.45) 0.4 (0.26, 0.46) NA (NA, NA) 0.48 (0.43, 0.49) 0.37 (0.24, 0.47) 0.44 (0.28, 0.46) 0.31 (0.17, 0.46) 0.33 (0.18, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.37 (0.37, 0.37) 0.22 (0.22, 0.22) 0.18 (0.18, 0.18) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.14 (0.14, 0.14) 0.12 (0.12, 0.12) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.247 (0.087, 0.256) 0.118 (0.101, 0.325) 0.172 (0.12, 0.526) 0.19 (0.098, 0.246) 0.164 (0.127, 0.233) 0.232 (0.111, 0.326) NA (NA, NA) 0.099 (0.035, 0.153) 0.193 (0.112, 0.309) 0.337 (0.157, 0.631) 0.163 (0.116, 0.24) 0.24 (0.119, 0.328) 0.07 (0.07, 0.07) NA (NA, NA) NA (NA, NA) 0 (0, 0)
TEfus+ TC2 count 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18
TEfus+ TC2 time 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33) 22 (16, 33)
TEfus+ TC2 n 1 (0, 2) 3 (2, 5) 2 (0, 4) 6 (2, 8) 4 (1, 8) 2 (0, 3) 0 (0, 0) 1 (0, 2) 2 (0, 4) 1 (0, 3) 6 (4, 11) 5 (2, 7) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.44 (0.36, 0.49) 0.39 (0.16, 0.48) 0.44 (0.32, 0.49) 0.39 (0.15, 0.46) 0.36 (0.1, 0.47) 0.4 (0.37, 0.45) NA (NA, NA) 0.39 (0.3, 0.47) 0.43 (0.37, 0.48) 0.4 (0.31, 0.46) 0.42 (0.23, 0.47) 0.39 (0.27, 0.47) 0.47 (0.42, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.25 (0.25, 0.25) 0.03 (0.03, 0.03) 0.41 (0.41, 0.41) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.29 (0.29, 0.29) 0.37 (0.37, 0.37) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.168 (0.129, 0.28) 0.148 (0.128, 0.272) 0.18 (0.131, 0.323) 0.154 (0.126, 0.547) 0.19 (0.097, 0.703) 0.175 (0.076, 0.757) NA (NA, NA) 0.259 (0.127, 0.415) 0.123 (0.102, 0.434) 0.231 (0.122, 3.646) 0.139 (0.112, 0.233) 0.153 (0.126, 0.337) 0.124 (0.102, 0.166) NA (NA, NA) 1.243 (1.243, 1.243) NA (NA, NA)
TEfus+ TC3 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
TEfus+ TC3 time 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16)
TEfus+ TC3 n 2 (2, 2) 1 (1, 1) 3 (3, 3) 3 (3, 3) 2 (2, 2) 0 (0, 0) 0 (0, 0) 3 (3, 3) 3 (3, 3) 0 (0, 0) 4 (4, 4) 5 (5, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p NA (NA, NA) 0.38 (0.38, 0.38) 0.45 (0.45, 0.45) 0.32 (0.32, 0.32) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) 0.42 (0.42, 0.42) 0.49 (0.49, 0.49) NA (NA, NA) 0.44 (0.44, 0.44) 0.17 (0.17, 0.17) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.153 (0.153, 0.153) 0.734 (0.734, 0.734) 0.097 (0.097, 0.097) 0.139 (0.139, 0.139) 0.046 (0.046, 0.046) NA (NA, NA) NA (NA, NA) 0.118 (0.118, 0.118) 0.144 (0.144, 0.144) NA (NA, NA) 0.199 (0.199, 0.199) 0.221 (0.221, 0.221) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
TEfus+ TC4 time 30 (25, 30) 30 (25, 30) 30 (25, 30) 30 (25, 30) 30 (25, 30) 30 (25, 30) 30 (25, 30) 30 (25, 30) 30 (25, 30) 30 (25, 30) 30 (25, 30) 30 (25, 30) 30 (25, 30) 30 (25, 30) 30 (25, 30) 30 (25, 30)
TEfus+ TC4 n 3 (1, 3) 5 (1, 5) 5 (2, 5) 5 (5, 7) 3 (1, 5) 1 (0, 2) 0 (0, 0) 0 (0, 0) 1 (0, 3) 1 (0, 2) 9 (6, 10) 4 (3, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.47 (0.47, 0.47) 0.41 (0.37, 0.44) 0.43 (0.38, 0.46) 0.3 (0.23, 0.39) 0.29 (0.24, 0.33) 0.36 (0.28, 0.43) NA (NA, NA) NA (NA, NA) 0.4 (0.38, 0.41) 0.47 (0.46, 0.48) 0.21 (0.18, 0.36) 0.27 (0.21, 0.43) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.12 (0.114, 0.127) 0.143 (0.139, 0.146) 0.104 (0.103, 2.258) 0.129 (0.123, 0.201) 0.138 (0.124, 0.151) 0.34 (0.251, 0.428) NA (NA, NA) NA (NA, NA) 0.214 (0.136, 0.293) 0.255 (0.152, 0.358) 0.15 (0.148, 0.166) 0.22 (0.146, 0.253) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 count 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13
TEfus+ TC5 time 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24) 20 (15, 24)
TEfus+ TC5 n 1 (0, 3) 3 (2, 4) 2 (0, 5) 7 (3, 9) 2 (1, 4) 1 (0, 4) 0 (0, 0) 0 (0, 1) 2 (1, 3) 0 (0, 1) 6 (3, 8) 3 (1, 6) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 post_p 0.4 (0.36, 0.45) 0.35 (0.23, 0.45) 0.38 (0.29, 0.46) 0.36 (0.26, 0.45) 0.43 (0.23, 0.49) 0.4 (0.27, 0.46) NA (NA, NA) 0.45 (0.41, 0.48) 0.42 (0.32, 0.49) 0.47 (0.42, 0.47) 0.35 (0.16, 0.45) 0.4 (0.28, 0.49) 0.41 (0.4, 0.42) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC5 r_prob 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC5 rate 0.182 (0.079, 0.283) 0.198 (0.12, 0.254) 0.287 (0.155, 0.665) 0.182 (0.119, 0.228) 0.168 (0.101, 0.529) 0.179 (0.068, 0.741) NA (NA, NA) 0.324 (0.019, 3.61) 0.203 (0.101, 0.364) 0.17 (0.073, 0.548) 0.173 (0.1, 0.206) 0.149 (0.098, 0.83) 0.126 (0.032, 11.878) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23
PI3K+ TC1 time 23 (15, 30) 23 (15, 30) 23 (15, 30) 23 (15, 30) 23 (15, 30) 23 (15, 30) 23 (15, 30) 23 (15, 30) 23 (15, 30) 23 (15, 30) 23 (15, 30) 23 (15, 30) 23 (15, 30) 23 (15, 30) 23 (15, 30) 23 (15, 30)
PI3K+ TC1 n 8 (5, 13) 3 (1, 6) 8 (4, 12) 6 (3, 10) 0 (0, 0) 1 (0, 4) 0 (0, 2) 1 (0, 3) 0 (0, 2) 1 (0, 3) 0 (0, 0) 4 (2, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.34 (0.16, 0.46) 0.35 (0.24, 0.45) 0.35 (0.18, 0.47) 0.31 (0.14, 0.47) NA (NA, NA) 0.43 (0.38, 0.47) 0.43 (0.35, 0.49) 0.43 (0.39, 0.49) 0.41 (0.3, 0.47) 0.4 (0.3, 0.48) NA (NA, NA) 0.4 (0.21, 0.45) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.22 (0.22, 0.22) 0.22 (0.22, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.14 (0.14, 0.14) 0.14 (0.14, 0.14) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.153 (0.113, 0.205) 0.174 (0.124, 0.32) 0.155 (0.11, 0.302) 0.184 (0.095, 0.276) NA (NA, NA) 0.103 (0, 1.197) 0.152 (0.042, 1.689) 0.106 (0.019, 0.345) 0.229 (0.074, 0.894) 0.277 (0.105, 0.62) NA (NA, NA) 0.157 (0.111, 0.36) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0)
PI3K+ TC2 count 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24
PI3K+ TC2 time 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30) 24 (14, 30)
PI3K+ TC2 n 6 (2, 11) 3 (1, 9) 8 (4, 10) 5 (2, 7) 0 (0, 0) 1 (0, 4) 0 (0, 3) 0 (0, 2) 0 (0, 1) 1 (0, 2) 0 (0, 0) 5 (2, 7) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 post_p 0.34 (0.19, 0.47) 0.42 (0.25, 0.5) 0.38 (0.16, 0.48) 0.37 (0.18, 0.47) NA (NA, NA) 0.44 (0.37, 0.48) 0.44 (0.4, 0.49) 0.46 (0.43, 0.49) 0.44 (0.36, 0.49) 0.45 (0.37, 0.49) NA (NA, NA) 0.41 (0.28, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 r_prob 0.03 (0.03, 0.03) 0.03 (0.03, 0.03) 0.07 (0.07, 0.07) 0.16 (0.16, 0.16) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.21 (0.21, 0.21) 0.21 (0.21, 0.21) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.149 (0.104, 0.341) 0.172 (0.105, 0.409) 0.147 (0.115, 0.214) 0.155 (0.121, 0.524) NA (NA, NA) 0.121 (0.078, 0.936) 0.155 (0.048, 0.23) 0.201 (0.126, 0.471) 0.616 (0.181, 1.581) 0.184 (0, 0.652) NA (NA, NA) 0.15 (0.106, 0.324) 0.239 (0.239, 0.239) NA (NA, NA) 0 (0, 0) NA (NA, NA)
PI3K+ TC3 count 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
PI3K+ TC3 time 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22) 18 (15, 22)
PI3K+ TC3 n 8 (5, 10) 5 (2, 8) 5 (4, 8) 7 (3, 9) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 2) 1 (0, 2) 0 (0, 0) 4 (2, 6) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC3 post_p 0.42 (0.25, 0.45) 0.43 (0.24, 0.46) 0.36 (0.15, 0.46) 0.32 (0.19, 0.42) NA (NA, NA) 0.43 (0.43, 0.43) 0.48 (0.48, 0.48) 0.47 (0.45, 0.49) NA (NA, NA) 0.42 (0.39, 0.47) NA (NA, NA) 0.36 (0.28, 0.44) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.141 (0.103, 0.22) 0.164 (0.104, 0.832) 0.165 (0.104, 0.219) 0.152 (0.119, 0.267) NA (NA, NA) 0.186 (0.037, 0.243) 1.36 (0.382, 2.337) 0.076 (0.019, 0.193) 0.215 (0.19, 0.24) 0.269 (0.086, 0.799) NA (NA, NA) 0.17 (0.107, 0.327) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 count 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11
PI3K+ TC4 time 18 (14, 28) 18 (14, 28) 18 (14, 28) 18 (14, 28) 18 (14, 28) 18 (14, 28) 18 (14, 28) 18 (14, 28) 18 (14, 28) 18 (14, 28) 18 (14, 28) 18 (14, 28) 18 (14, 28) 18 (14, 28) 18 (14, 28) 18 (14, 28)
PI3K+ TC4 n 7 (4, 10) 4 (3, 7) 7 (5, 10) 4 (1, 9) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 0) 1 (0, 2) 0 (0, 2) 0 (0, 0) 4 (2, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC4 post_p 0.31 (0.09, 0.46) 0.36 (0.19, 0.44) 0.36 (0.3, 0.48) 0.43 (0.28, 0.48) NA (NA, NA) 0.42 (0.42, 0.42) 0.48 (0.44, 0.49) 0.37 (0.37, 0.37) 0.47 (0.46, 0.49) 0.42 (0.4, 0.45) NA (NA, NA) 0.34 (0.17, 0.42) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
PI3K+ TC4 r_prob 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.209 (0.115, 0.321) 0.17 (0.124, 0.324) 0.168 (0.119, 0.202) 0.133 (0.1, 0.199) NA (NA, NA) 0.143 (0.143, 0.143) 0.072 (0, 0.91) 0.479 (0.479, 0.479) 0.16 (0, 0.274) 0.216 (0.098, 0.83) NA (NA, NA) 0.234 (0.152, 0.331) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.651 (0.651, 0.651)
PI3K+ TC5 count 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30
PI3K+ TC5 time 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33)
PI3K+ TC5 n 8 (3, 14) 3 (1, 5) 7 (3, 11) 6 (3, 10) 0 (0, 0) 2 (0, 3) 1 (0, 2) 0 (0, 2) 0 (0, 1) 1 (0, 2) 0 (0, 0) 4 (2, 8) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 post_p 0.38 (0.22, 0.48) 0.41 (0.2, 0.48) 0.31 (0.14, 0.48) 0.4 (0.22, 0.45) NA (NA, NA) 0.39 (0.29, 0.45) 0.44 (0.33, 0.47) 0.43 (0.35, 0.49) 0.44 (0.32, 0.49) 0.43 (0.36, 0.48) NA (NA, NA) 0.42 (0.29, 0.49) NA (NA, NA) 0.44 (0.44, 0.44) NA (NA, NA) NA (NA, NA)
PI3K+ TC5 r_prob 0.38 (0.38, 0.38) 0.38 (0.38, 0.38) 0.33 (0.33, 0.33) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC5 rate 0.143 (0.103, 0.242) 0.212 (0.133, 0.447) 0.166 (0.113, 0.251) 0.157 (0.109, 0.226) NA (NA, NA) 0.132 (0.077, 0.369) 0.264 (0.147, 2.309) 0.159 (0, 1.092) 0.259 (0.053, 1.416) 0.17 (0.095, 0.578) 0.4 (0.4, 0.4) 0.149 (0.106, 0.302) 0.335 (0.335, 0.335) 0.282 (0.282, 0.282) NA (NA, NA) 0 (0, 0)