Simulation scenario 9, CR phase

Setting description

Equal randomization: TC3 and TC4 more effective in the HRD+ biomarker signature (cfr scen 5)

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4	TC5
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.099, shape = 1.05	scale = 0.099, shape = 1.05	scale = 0.112, shape = 1.05
all	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 9.9, median = 7.1	mean = 9.9, median = 7.1	mean = 8.8, median = 6.3
all	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.13, hr = 0.88	af = 1.13, hr = 0.88	af = 1, hr = 1
AR- & TP53-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.096, shape = 1.05	scale = 0.096, shape = 1.05	scale = 0.112, shape = 1.05
AR- & TP53-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 10.2, median = 7.4	mean = 10.2, median = 7.4	mean = 8.8, median = 6.3
AR- & TP53-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.16, hr = 0.85	af = 1.16, hr = 0.85	af = 1, hr = 1
HRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
HRD+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
HRD+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.107, shape = 1.05	scale = 0.107, shape = 1.05	scale = 0.112, shape = 1.05
TP53+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 9.2, median = 6.6	mean = 9.2, median = 6.6	mean = 8.8, median = 6.3
TP53+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.04, hr = 0.96	af = 1.04, hr = 0.96	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.097, shape = 1.05	scale = 0.097, shape = 1.05	scale = 0.112, shape = 1.05
TEfus+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 10.1, median = 7.3	mean = 10.1, median = 7.3	mean = 8.8, median = 6.3
TEfus+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.15, hr = 0.87	af = 1.15, hr = 0.87	af = 1, hr = 1
PI3K+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.104, shape = 1.05	scale = 0.104, shape = 1.05	scale = 0.112, shape = 1.05
PI3K+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 9.4, median = 6.8	mean = 9.4, median = 6.8	mean = 8.8, median = 6.3
PI3K+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.07, hr = 0.93	af = 1.07, hr = 0.93	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4	TC5
—–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
—++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
—++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
–+++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
–+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+—	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+—	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
-+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+–+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+–+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
-+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+-+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+-+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
-+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+-++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+-++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
-++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-++–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
-++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-++-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
-+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-+++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-+++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
-++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
-++++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
-++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
+—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+—+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+—+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+–+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+–+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+–++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+–++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
+-+++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
+-+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++—	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++—	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
++–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++–+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++–+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
++-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++-+-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++-+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
++-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++-++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++-++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
+++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
+++–	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
+++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
+++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
+++-+	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
+++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
++++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
++++-	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
++++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1
+++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.036, shape = 1.05	scale = 0.112, shape = 1.05
+++++	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 27.4, median = 19.7	mean = 27.4, median = 19.7	mean = 8.8, median = 6.3
+++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.12, hr = 0.3	af = 3.12, hr = 0.3	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 4 2 4 7 3 AR- & TP53- 13 8 65 62 10 HRD+ 1 0 220 219 0 TP53+ 4 2 6 4 3 TEfus+ 2 0 6 3 0 PI3K+ 2 3 9 6 1

TC1 TC2 TC3 TC4 TC5 all 0.008 0.004 0.008 0.014 0.006 AR- & TP53- 0.026 0.016 0.130 0.124 0.020 HRD+ 0.002 0.000 0.440 0.438 0.000 TP53+ 0.008 0.004 0.012 0.008 0.006 TEfus+ 0.004 0.000 0.012 0.006 0.000 PI3K+ 0.004 0.006 0.018 0.012 0.002

futility (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 0 3 0 0 5 AR- & TP53- 77 94 4 10 79 HRD+ 61 67 0 0 74 TP53+ 30 36 14 11 30 TEfus+ 8 18 1 3 13 PI3K+ 23 24 9 11 30

TC1 TC2 TC3 TC4 TC5 all 0.000 0.006 0.000 0.000 0.010 AR- & TP53- 0.154 0.188 0.008 0.020 0.158 HRD+ 0.122 0.134 0.000 0.000 0.148 TP53+ 0.060 0.072 0.028 0.022 0.060 TEfus+ 0.016 0.036 0.002 0.006 0.026 PI3K+ 0.046 0.048 0.018 0.022 0.060

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 TC5 all 0 0 0 0 0 AR- & TP53- 8 7 6 5 7 HRD+ 0 0 0 0 0 TP53+ 0 0 0 0 0 TEfus+ 0 0 0 0 0 PI3K+ 0 0 0 0 0

TC1 TC2 TC3 TC4 TC5 all 0.000 0.000 0.000 0.00 0.000 AR- & TP53- 0.016 0.014 0.012 0.01 0.014 HRD+ 0.000 0.000 0.000 0.00 0.000 TP53+ 0.000 0.000 0.000 0.00 0.000 TEfus+ 0.000 0.000 0.000 0.00 0.000 PI3K+ 0.000 0.000 0.000 0.00 0.000

Operating characteristics

char	overall	TC1	TC2	TC3	TC4	TC5
err_sign	0.344	0.052	0.03	0.136	0.140	0.032
err_type	0.374	0.052	0.03	0.168	0.154	0.032
pow_sign	0.678	0.000	0.00	0.440	0.438	0.000
pow_type	0.788	0.000	0.00	0.576	0.578	0.000

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4	TC5
all	graduation	0	4	2	4	7	3
all	futility	0	0	3	0	0	5
all	max_n	0	0	0	0	0	0
all	n	382 (357, 403)	163 (113, 191)	162 (108, 193)	163 (117, 192)	164 (115, 193)	163 (109, 195)
all	n_unique	349 (327, 368)	150 (103, 176)	148 (98, 179)	150 (108, 177)	150 (105, 177)	149 (100, 179)
all	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
all	time_stop	NA (NA, NA)	6 (5, 8)	7 (6, 13)	6 (5, 7)	7 (5, 10)	8 (5, 14)
all	post_p	NA (NA, NA)	0.51 (0.12, 0.88)	0.44 (0.08, 0.83)	0.97 (0.74, 1)	0.97 (0.73, 1)	0.49 (0.09, 0.89)
all	rate	0.112 (0.105, 0.12)	0.112 (0.1, 0.125)	0.113 (0.103, 0.128)	0.091 (0.08, 0.103)	0.091 (0.081, 0.104)	0.112 (0.101, 0.125)
AR- & TP53-	graduation	0	13	8	65	62	10
AR- & TP53-	futility	0	77	94	4	10	79
AR- & TP53-	max_n	0	8	7	6	5	7
AR- & TP53-	n	212 (195, 232)	92 (40, 113)	92 (33, 116)	93 (43, 116)	93 (39, 114)	92 (39, 118)
AR- & TP53-	n_unique	195 (179, 214)	85 (37, 106)	85 (30, 108)	86 (40, 108)	86 (36, 106)	86 (36, 111)
AR- & TP53-	time_trial	36 (36, 36)	36 (15, 36)	36 (15, 36)	36 (19, 36)	36 (18, 36)	36 (17, 36)
AR- & TP53-	time_stop	NA (NA, NA)	14 (9, 31)	15 (9, 30)	13 (10, 25)	13 (9, 25)	15 (10, 33)
AR- & TP53-	post_p	NA (NA, NA)	0.48 (0.09, 0.91)	0.41 (0.09, 0.84)	0.95 (0.69, 1)	0.96 (0.65, 1)	0.47 (0.09, 0.86)
AR- & TP53-	rate	0.113 (0.102, 0.123)	0.112 (0.095, 0.134)	0.115 (0.1, 0.138)	0.087 (0.072, 0.103)	0.087 (0.073, 0.105)	0.113 (0.097, 0.134)
HRD+	graduation	0	1	0	220	219	0
HRD+	futility	0	61	67	0	0	74
HRD+	max_n	0	0	0	0	0	0
HRD+	n	64 (54, 75)	28 (18, 37)	28 (17, 39)	25 (18, 34)	26 (18, 34)	28 (17, 39)
HRD+	n_unique	58 (48, 69)	25 (15, 34)	25 (15, 35)	23 (16, 30)	24 (16, 31)	25 (15, 35)
HRD+	time_trial	36 (36, 36)	36 (35, 36)	36 (34, 36)	36 (27, 36)	36 (27, 36)	36 (33, 36)
HRD+	time_stop	NA (NA, NA)	30 (23, 35)	31 (24, 35)	30 (24, 35)	30 (24, 35)	31 (22, 35)
HRD+	post_p	NA (NA, NA)	0.36 (0.08, 0.79)	0.3 (0.05, 0.74)	1 (0.99, 1)	1 (0.99, 1)	0.31 (0.06, 0.73)
HRD+	rate	0.112 (0.094, 0.134)	0.112 (0.084, 0.149)	0.117 (0.088, 0.154)	0.035 (0.024, 0.049)	0.036 (0.024, 0.051)	0.117 (0.087, 0.154)
TP53+	graduation	0	4	2	6	4	3
TP53+	futility	0	30	36	14	11	30
TP53+	max_n	0	0	0	0	0	0
TP53+	n	134 (121, 148)	57 (43, 69)	57 (43, 69)	57 (45, 71)	57 (44, 69)	57 (42, 69)
TP53+	n_unique	122 (110, 135)	51 (38, 63)	51 (38, 63)	52 (40, 64)	52 (39, 63)	52 (38, 62)
TP53+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
TP53+	time_stop	NA (NA, NA)	20 (14, 32)	22 (15, 32)	23 (14, 30)	20 (15, 31)	20 (14, 32)
TP53+	post_p	NA (NA, NA)	0.5 (0.12, 0.89)	0.5 (0.09, 0.85)	0.67 (0.24, 0.96)	0.64 (0.2, 0.94)	0.51 (0.12, 0.88)
TP53+	rate	0.113 (0.1, 0.127)	0.113 (0.092, 0.138)	0.112 (0.094, 0.141)	0.103 (0.085, 0.126)	0.106 (0.086, 0.129)	0.112 (0.093, 0.139)
TEfus+	graduation	0	2	0	6	3	0
TEfus+	futility	0	8	18	1	3	13
TEfus+	max_n	0	0	0	0	0	0
TEfus+	n	127 (114, 143)	54 (40, 67)	55 (39, 67)	54 (42, 67)	54 (41, 66)	54 (39, 67)
TEfus+	n_unique	116 (103, 129)	49 (35, 61)	50 (34, 61)	48 (38, 60)	49 (37, 59)	49 (36, 61)
TEfus+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
TEfus+	time_stop	NA (NA, NA)	22 (16, 30)	22 (16, 33)	18 (15, 31)	25 (17, 30)	20 (15, 24)
TEfus+	post_p	NA (NA, NA)	0.48 (0.11, 0.88)	0.46 (0.1, 0.83)	0.89 (0.49, 0.99)	0.88 (0.46, 0.99)	0.48 (0.12, 0.87)
TEfus+	rate	0.113 (0.099, 0.127)	0.112 (0.092, 0.136)	0.114 (0.096, 0.142)	0.089 (0.073, 0.109)	0.09 (0.072, 0.113)	0.112 (0.093, 0.139)
PI3K+	graduation	0	2	3	9	6	1
PI3K+	futility	0	23	24	9	11	30
PI3K+	max_n	0	0	0	0	0	0
PI3K+	n	129 (116, 143)	56 (38, 70)	55 (37, 69)	56 (40, 70)	56 (40, 69)	55 (38, 70)
PI3K+	n_unique	119 (106, 131)	50 (34, 64)	50 (34, 62)	50 (36, 64)	51 (36, 63)	50 (34, 63)
PI3K+	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
PI3K+	time_stop	NA (NA, NA)	23 (15, 30)	23 (14, 30)	19 (14, 28)	18 (14, 25)	23 (13, 33)
PI3K+	post_p	NA (NA, NA)	0.49 (0.1, 0.87)	0.46 (0.1, 0.85)	0.78 (0.28, 0.98)	0.74 (0.27, 0.97)	0.5 (0.09, 0.86)
PI3K+	rate	0.113 (0.1, 0.127)	0.112 (0.094, 0.137)	0.114 (0.094, 0.139)	0.099 (0.08, 0.122)	0.1 (0.08, 0.124)	0.113 (0.094, 0.139)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4	TC5
—–	graduation	0	17	10	69	67	12
—–	futility	0	77	96	4	10	81
—–	max_n	0	8	7	6	5	7
—–	n	117 (105, 131)	50 (21, 63)	49 (18, 64)	51 (24, 66)	51 (21, 65)	50 (22, 66)
—–	n_unique	108 (97, 122)	48 (20, 60)	46 (17, 61)	48 (23, 62)	48 (20, 61)	48 (21, 63)
—–	post_p	NA (NA, NA)	0.53 (0.12, 0.89)	0.48 (0.1, 0.86)	0.5 (0.13, 0.87)	0.49 (0.12, 0.88)	0.51 (0.13, 0.88)
—–	rate	0.113 (0.099, 0.127)	0.112 (0.089, 0.141)	0.115 (0.094, 0.147)	0.112 (0.092, 0.138)	0.113 (0.091, 0.139)	0.113 (0.092, 0.14)
—-+	graduation	0	19	13	75	71	13
—-+	futility	0	93	108	13	21	97
—-+	max_n	0	8	7	6	5	7
—-+	n	30 (23, 38)	13 (5, 19)	12 (4, 19)	13 (5, 19)	13 (5, 19)	13 (5, 19)
—-+	n_unique	27 (20, 35)	12 (5, 17)	11 (4, 17)	12 (5, 17)	12 (4, 18)	12 (5, 17)
—-+	post_p	NA (NA, NA)	0.47 (0.18, 0.85)	0.51 (0.16, 0.85)	0.5 (0.16, 0.83)	0.52 (0.16, 0.87)	0.48 (0.16, 0.86)
—-+	rate	0.114 (0.089, 0.149)	0.117 (0.075, 0.18)	0.118 (0.077, 0.191)	0.119 (0.079, 0.176)	0.113 (0.072, 0.178)	0.117 (0.074, 0.193)
—+-	graduation	0	19	10	74	68	12
—+-	futility	0	83	104	5	12	89
—+-	max_n	0	8	7	6	5	7
—+-	n	6 (3, 10)	2 (0, 5)	2 (0, 5)	3 (0, 5)	2 (0, 5)	2 (0, 5)
—+-	n_unique	5 (2, 9)	2 (0, 5)	2 (0, 4)	2 (0, 5)	2 (0, 4)	2 (0, 5)
—+-	post_p	NA (NA, NA)	0.49 (0.27, 0.75)	0.49 (0.28, 0.75)	0.47 (0.26, 0.74)	0.48 (0.28, 0.72)	0.5 (0.28, 0.76)
—+-	rate	0.117 (0.062, 0.228)	0.12 (0.041, 0.363)	0.126 (0.039, 0.381)	0.132 (0.046, 0.342)	0.129 (0.045, 0.377)	0.118 (0.045, 0.411)
—++	graduation	0	21	13	79	72	13
—++	futility	0	97	114	14	22	103
—++	max_n	0	8	7	6	5	7
—++	n	14 (10, 19)	6 (2, 10)	6 (2, 10)	6 (2, 10)	6 (2, 10)	6 (2, 10)
—++	n_unique	13 (8, 18)	5 (2, 9)	5 (2, 9)	5 (2, 9)	5 (2, 9)	5 (2, 9)
—++	post_p	NA (NA, NA)	0.48 (0.2, 0.81)	0.47 (0.2, 0.81)	0.53 (0.21, 0.83)	0.53 (0.22, 0.82)	0.46 (0.2, 0.81)
—++	rate	0.118 (0.079, 0.176)	0.122 (0.068, 0.24)	0.124 (0.067, 0.267)	0.116 (0.06, 0.219)	0.115 (0.063, 0.235)	0.124 (0.066, 0.241)
–+–	graduation	0	8	4	10	11	6
–+–	futility	0	30	38	14	11	33
–+–	max_n	0	0	0	0	0	0
–+–	n	28 (21, 35)	12 (7, 16)	11 (7, 16)	12 (7, 17)	12 (7, 17)	12 (7, 17)
–+–	n_unique	25 (19, 33)	10 (6, 15)	10 (6, 15)	11 (7, 15)	11 (6, 15)	11 (6, 16)
–+–	post_p	NA (NA, NA)	0.51 (0.14, 0.85)	0.5 (0.17, 0.84)	0.49 (0.16, 0.82)	0.48 (0.17, 0.83)	0.49 (0.16, 0.86)
–+–	rate	0.111 (0.086, 0.147)	0.112 (0.073, 0.182)	0.115 (0.075, 0.177)	0.115 (0.075, 0.174)	0.116 (0.076, 0.178)	0.115 (0.072, 0.177)
–+-+	graduation	0	10	7	18	16	7
–+-+	futility	0	48	58	21	20	54
–+-+	max_n	0	0	0	0	0	0
–+-+	n	26 (20, 33)	11 (7, 16)	11 (6, 16)	11 (7, 16)	11 (7, 16)	11 (6, 15)
–+-+	n_unique	24 (18, 30)	10 (6, 15)	10 (5, 14)	10 (6, 15)	10 (6, 15)	10 (5, 14)
–+-+	post_p	NA (NA, NA)	0.51 (0.17, 0.83)	0.5 (0.17, 0.83)	0.53 (0.17, 0.87)	0.48 (0.19, 0.82)	0.49 (0.16, 0.85)
–+-+	rate	0.116 (0.083, 0.15)	0.117 (0.075, 0.182)	0.114 (0.078, 0.174)	0.113 (0.071, 0.18)	0.114 (0.077, 0.172)	0.116 (0.07, 0.189)
–++-	graduation	0	10	4	16	14	6
–++-	futility	0	36	50	14	14	39
–++-	max_n	0	0	0	0	0	0
–++-	n	8 (5, 12)	3 (1, 6)	3 (1, 6)	3 (1, 6)	3 (1, 6)	3 (1, 6)
–++-	n_unique	7 (4, 11)	3 (1, 6)	3 (1, 6)	3 (1, 6)	3 (1, 6)	3 (1, 6)
–++-	post_p	NA (NA, NA)	0.49 (0.27, 0.78)	0.46 (0.23, 0.75)	0.51 (0.26, 0.77)	0.5 (0.27, 0.79)	0.46 (0.23, 0.75)
–++-	rate	0.114 (0.068, 0.199)	0.12 (0.051, 0.297)	0.126 (0.057, 0.315)	0.112 (0.055, 0.321)	0.118 (0.048, 0.302)	0.13 (0.047, 0.346)
–+++	graduation	0	12	7	22	18	7
–+++	futility	0	53	67	21	22	59
–+++	max_n	0	0	0	0	0	0
–+++	n	20 (15, 27)	9 (5, 13)	8 (4, 12)	9 (5, 14)	9 (5, 13)	8 (4, 13)
–+++	n_unique	19 (13, 25)	8 (4, 12)	7 (4, 12)	8 (4, 12)	8 (4, 12)	8 (4, 12)
–+++	post_p	NA (NA, NA)	0.49 (0.19, 0.82)	0.48 (0.14, 0.84)	0.53 (0.2, 0.86)	0.47 (0.19, 0.83)	0.5 (0.18, 0.84)
–+++	rate	0.112 (0.084, 0.159)	0.117 (0.071, 0.204)	0.117 (0.069, 0.214)	0.111 (0.068, 0.185)	0.119 (0.071, 0.197)	0.114 (0.067, 0.2)
-+—	graduation	0	18	10	278	278	12
-+—	futility	0	130	159	4	10	143
-+—	max_n	0	7	7	5	5	7
-+—	n	26 (20, 32)	11 (5, 17)	11 (4, 18)	11 (5, 16)	11 (5, 16)	11 (5, 18)
-+—	n_unique	24 (17, 30)	10 (4, 15)	10 (4, 16)	10 (5, 14)	10 (4, 15)	10 (4, 16)
-+—	post_p	NA (NA, NA)	0.34 (0.1, 0.7)	0.33 (0.09, 0.72)	0.97 (0.79, 1)	0.97 (0.77, 1)	0.32 (0.1, 0.7)
-+—	rate	0.112 (0.084, 0.15)	0.118 (0.074, 0.19)	0.119 (0.078, 0.195)	0.036 (0.018, 0.06)	0.036 (0.016, 0.06)	0.117 (0.076, 0.191)
-+–+	graduation	0	20	13	281	281	12
-+–+	futility	0	143	169	12	19	154
-+–+	max_n	0	7	7	5	5	7
-+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+–+	post_p	NA (NA, NA)	0.46 (0.44, 0.47)	0.5 (0.47, 0.53)	0.53 (0.48, 0.54)	0.55 (0.54, 0.56)	0.49 (0.45, 0.54)
-+–+	rate	0.123 (0, 0.405)	0.257 (0.098, 0.624)	0.311 (0.047, 0.665)	0.06 (0, 0.782)	0.038 (0, 0.197)	0.339 (0.036, 5.583)
-+-+-	graduation	0	20	10	281	277	12
-+-+-	futility	0	134	166	5	12	149
-+-+-	max_n	0	7	7	5	5	7
-+-+-	n	13 (9, 18)	5 (2, 10)	5 (2, 10)	5 (2, 9)	5 (2, 9)	6 (2, 10)
-+-+-	n_unique	12 (7, 17)	5 (1, 9)	5 (2, 9)	4 (2, 8)	4 (2, 8)	5 (1, 9)
-+-+-	post_p	NA (NA, NA)	0.4 (0.17, 0.7)	0.4 (0.16, 0.67)	0.86 (0.57, 0.98)	0.85 (0.56, 0.97)	0.39 (0.19, 0.67)
-+-+-	rate	0.12 (0.078, 0.174)	0.117 (0.062, 0.237)	0.121 (0.061, 0.282)	0.035 (0.011, 0.08)	0.036 (0.014, 0.087)	0.122 (0.061, 0.235)
-+-++	graduation	0	22	13	283	280	12
-+-++	futility	0	146	174	13	20	159
-+-++	max_n	0	7	7	5	5	7
-+-++	n	6 (3, 9)	2 (0, 5)	2 (0, 5)	2 (0, 5)	2 (0, 5)	2 (0, 5)
-+-++	n_unique	5 (2, 8)	2 (0, 4)	2 (0, 5)	2 (0, 4)	2 (0, 4)	2 (0, 4)
-+-++	post_p	NA (NA, NA)	0.44 (0.27, 0.66)	0.44 (0.27, 0.63)	0.67 (0.47, 0.87)	0.67 (0.44, 0.87)	0.44 (0.27, 0.64)
-+-++	rate	0.113 (0.056, 0.217)	0.119 (0.04, 0.35)	0.123 (0.049, 0.407)	0.034 (0, 0.121)	0.033 (0, 0.138)	0.12 (0.042, 0.419)
-++–	graduation	0	8	3	227	230	5
-++–	futility	0	86	99	12	9	102
-++–	max_n	0	0	0	0	0	0
-++–	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-++–	post_p	NA (NA, NA)	0.47 (0.47, 0.48)	0.49 (0.47, 0.52)	0.5 (0.5, 0.5)	NA (NA, NA)	0.43 (0.43, 0.43)
-++–	rate	0.088 (0, 0.609)	0.219 (0, 0.976)	0.134 (0, 1.078)	0 (0, 0.376)	0.072 (0, 0.107)	0.198 (0, 0.614)
-++-+	graduation	0	10	6	232	234	5
-++-+	futility	0	101	116	18	16	119
-++-+	max_n	0	0	0	0	0	0
-++-+	n	3 (1, 6)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)
-++-+	n_unique	3 (1, 6)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)
-++-+	post_p	NA (NA, NA)	0.45 (0.3, 0.62)	0.44 (0.32, 0.63)	0.61 (0.43, 0.8)	0.6 (0.43, 0.81)	0.45 (0.31, 0.61)
-++-+	rate	0.115 (0.044, 0.307)	0.133 (0, 0.565)	0.14 (0.034, 0.528)	0.035 (0, 0.179)	0.032 (0, 0.209)	0.136 (0.027, 0.581)
-+++-	graduation	0	10	3	231	231	5
-+++-	futility	0	89	111	12	12	106
-+++-	max_n	0	0	0	0	0	0
-+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
-+++-	post_p	NA (NA, NA)	0.57 (0.53, 0.6)	0.41 (0.4, 0.53)	NA (NA, NA)	0.62 (0.56, 0.67)	0.48 (0.48, 0.48)
-+++-	rate	0.104 (0, 0.823)	0.122 (0, 0.696)	0.125 (0.021, 0.385)	0.076 (0, 0.291)	0 (0, 0.145)	0.141 (0, 0.539)
-++++	graduation	0	12	6	234	234	5
-++++	futility	0	104	125	18	18	122
-++++	max_n	0	0	0	0	0	0
-++++	n	3 (1, 6)	1 (0, 3)	2 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 4)
-++++	n_unique	3 (1, 6)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)
-++++	post_p	NA (NA, NA)	0.45 (0.34, 0.64)	0.44 (0.31, 0.63)	0.62 (0.44, 0.81)	0.61 (0.44, 0.81)	0.46 (0.3, 0.64)
-++++	rate	0.12 (0.052, 0.321)	0.126 (0, 0.433)	0.133 (0.028, 0.461)	0.028 (0, 0.135)	0.032 (0, 0.148)	0.129 (0, 0.506)
+—-	graduation	0	4	2	4	7	3
+—-	futility	0	0	3	0	0	5
+—-	max_n	0	0	0	0	0	0
+—-	n	6 (3, 10)	2 (1, 5)	2 (0, 5)	2 (1, 5)	2 (1, 5)	2 (1, 5)
+—-	n_unique	5 (3, 9)	2 (0, 4)	2 (0, 4)	2 (1, 5)	2 (0, 4)	2 (0, 4)
+—-	post_p	NA (NA, NA)	0.49 (0.28, 0.71)	0.48 (0.3, 0.72)	0.5 (0.29, 0.74)	0.47 (0.27, 0.7)	0.48 (0.27, 0.71)
+—-	rate	0.111 (0.062, 0.217)	0.123 (0.052, 0.365)	0.125 (0.045, 0.331)	0.116 (0.03, 0.389)	0.127 (0.046, 0.363)	0.122 (0.042, 0.363)
+—+	graduation	0	6	5	13	13	4
+—+	futility	0	23	27	9	11	34
+—+	max_n	0	0	0	0	0	0
+—+	n	3 (1, 5)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)	1 (0, 3)
+—+	n_unique	2 (1, 5)	1 (0, 3)	1 (0, 3)	1 (0, 2)	1 (0, 3)	1 (0, 2)
+—+	post_p	NA (NA, NA)	0.47 (0.32, 0.66)	0.49 (0.36, 0.67)	0.48 (0.35, 0.66)	0.48 (0.37, 0.69)	0.48 (0.35, 0.7)
+—+	rate	0.121 (0.036, 0.346)	0.139 (0, 0.6)	0.123 (0, 0.658)	0.145 (0, 0.666)	0.131 (0, 0.659)	0.126 (0, 0.634)
+–+-	graduation	0	6	2	10	10	3
+–+-	futility	0	8	20	1	3	18
+–+-	max_n	0	0	0	0	0	0
+–+-	n	9 (5, 13)	4 (2, 6)	4 (1, 6)	4 (1, 7)	4 (2, 7)	4 (1, 7)
+–+-	n_unique	8 (5, 12)	3 (1, 6)	3 (1, 6)	3 (1, 6)	4 (1, 6)	3 (1, 6)
+–+-	post_p	NA (NA, NA)	0.5 (0.25, 0.75)	0.49 (0.28, 0.75)	0.48 (0.25, 0.78)	0.51 (0.25, 0.78)	0.49 (0.23, 0.77)
+–+-	rate	0.119 (0.069, 0.193)	0.119 (0.05, 0.262)	0.12 (0.054, 0.259)	0.122 (0.047, 0.264)	0.115 (0.051, 0.282)	0.119 (0.05, 0.294)
+–++	graduation	0	8	5	17	15	4
+–++	futility	0	29	39	10	13	43
+–++	max_n	0	0	0	0	0	0
+–++	n	4 (2, 8)	2 (0, 4)	2 (0, 4)	2 (0, 4)	2 (0, 4)	2 (0, 4)
+–++	n_unique	4 (2, 7)	2 (0, 4)	2 (0, 4)	1 (0, 4)	2 (0, 4)	2 (0, 3)
+–++	post_p	NA (NA, NA)	0.49 (0.31, 0.73)	0.48 (0.31, 0.7)	0.49 (0.31, 0.73)	0.48 (0.31, 0.71)	0.5 (0.32, 0.71)
+–++	rate	0.12 (0.056, 0.259)	0.125 (0.037, 0.397)	0.124 (0.04, 0.46)	0.125 (0.028, 0.437)	0.126 (0.029, 0.416)	0.118 (0.009, 0.456)
+-+–	graduation	0	8	4	10	11	6
+-+–	futility	0	30	38	14	11	33
+-+–	max_n	0	0	0	0	0	0
+-+–	n	2 (0, 4)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	n_unique	2 (0, 4)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
+-+–	post_p	NA (NA, NA)	0.49 (0.37, 0.61)	0.48 (0.38, 0.66)	0.49 (0.38, 0.64)	0.51 (0.37, 0.65)	0.48 (0.39, 0.62)
+-+–	rate	0.13 (0.032, 0.428)	0.12 (0, 0.64)	0.136 (0, 0.8)	0.122 (0, 0.716)	0.123 (0, 0.781)	0.138 (0, 0.743)
+-+-+	graduation	0	10	7	18	16	7
+-+-+	futility	0	48	58	21	20	54
+-+-+	max_n	0	0	0	0	0	0
+-+-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+-+-+	post_p	NA (NA, NA)	0.46 (0.46, 0.46)	0.55 (0.54, 0.55)	0.5 (0.45, 0.51)	0.57 (0.57, 0.57)	0.48 (0.46, 0.58)
+-+-+	rate	0.199 (0, 0.85)	0.197 (0, 1.492)	0.125 (0, 1.01)	0.099 (0, 0.475)	0.142 (0, 0.915)	0.121 (0, 0.457)
+-++-	graduation	0	10	4	16	14	6
+-++-	futility	0	36	50	14	14	39
+-++-	max_n	0	0	0	0	0	0
+-++-	n	22 (17, 29)	9 (5, 14)	9 (5, 14)	9 (5, 14)	10 (5, 14)	9 (5, 14)
+-++-	n_unique	20 (15, 26)	9 (4, 13)	8 (5, 13)	8 (4, 13)	8 (4, 13)	8 (4, 13)
+-++-	post_p	NA (NA, NA)	0.5 (0.18, 0.85)	0.48 (0.15, 0.8)	0.51 (0.18, 0.81)	0.5 (0.18, 0.84)	0.51 (0.17, 0.84)
+-++-	rate	0.113 (0.086, 0.151)	0.113 (0.073, 0.195)	0.119 (0.07, 0.205)	0.114 (0.074, 0.191)	0.115 (0.068, 0.194)	0.115 (0.07, 0.192)
+-+++	graduation	0	12	7	22	18	7
+-+++	futility	0	53	67	21	22	59
+-+++	max_n	0	0	0	0	0	0
+-+++	n	17 (12, 23)	7 (3, 11)	7 (3, 12)	7 (4, 11)	7 (4, 11)	7 (3, 11)
+-+++	n_unique	16 (11, 21)	7 (3, 10)	7 (3, 11)	7 (3, 10)	7 (3, 10)	7 (3, 10)
+-+++	post_p	NA (NA, NA)	0.49 (0.2, 0.83)	0.48 (0.19, 0.81)	0.48 (0.19, 0.82)	0.47 (0.18, 0.81)	0.51 (0.2, 0.84)
+-+++	rate	0.112 (0.078, 0.155)	0.116 (0.066, 0.204)	0.116 (0.065, 0.224)	0.12 (0.066, 0.203)	0.12 (0.066, 0.213)	0.111 (0.06, 0.223)
++—	graduation	0	5	2	224	226	3
++—	futility	0	61	70	0	0	79
++—	max_n	0	0	0	0	0	0
++—	n	9 (6, 14)	4 (2, 7)	4 (2, 7)	4 (1, 7)	4 (1, 7)	4 (2, 7)
++—	n_unique	9 (5, 13)	4 (1, 6)	4 (1, 6)	3 (1, 6)	3 (1, 6)	3 (1, 7)
++—	post_p	NA (NA, NA)	0.41 (0.18, 0.66)	0.4 (0.17, 0.65)	0.77 (0.51, 0.94)	0.77 (0.5, 0.93)	0.4 (0.18, 0.67)
++—	rate	0.11 (0.07, 0.183)	0.121 (0.053, 0.261)	0.12 (0.055, 0.301)	0.033 (0, 0.095)	0.036 (0, 0.096)	0.119 (0.055, 0.294)
++–+	graduation	0	7	5	229	231	3
++–+	futility	0	81	91	8	9	101
++–+	max_n	0	0	0	0	0	0
++–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++–+	post_p	NA (NA, NA)	NA (NA, NA)	0.5 (0.49, 0.52)	0.52 (0.5, 0.54)	0.53 (0.47, 0.66)	0.42 (0.42, 0.42)
++–+	rate	0.12 (0, 0.71)	0.166 (0, 0.273)	0.128 (0, 0.337)	0 (0, 0.238)	0 (0, 0.182)	0.22 (0, 1.846)
++-+-	graduation	0	7	2	228	227	3
++-+-	futility	0	66	86	1	3	89
++-+-	max_n	0	0	0	0	0	0
++-+-	n	1 (0, 3)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 1)
++-+-	n_unique	1 (0, 3)	0 (0, 2)	0 (0, 2)	0 (0, 1)	0 (0, 2)	0 (0, 1)
++-+-	post_p	NA (NA, NA)	0.47 (0.4, 0.61)	0.46 (0.37, 0.6)	0.56 (0.42, 0.63)	0.56 (0.44, 0.65)	0.49 (0.39, 0.59)
++-+-	rate	0.144 (0, 0.418)	0.125 (0, 0.551)	0.147 (0, 0.626)	0.032 (0, 0.222)	0.032 (0, 0.201)	0.118 (0, 0.894)
++-++	graduation	0	9	5	231	231	3
++-++	futility	0	85	102	9	11	108
++-++	max_n	0	0	0	0	0	0
++-++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++-++	post_p	NA (NA, NA)	0.49 (0.48, 0.5)	0.44 (0.44, 0.44)	NA (NA, NA)	0.46 (0.44, 0.54)	0.49 (0.45, 0.51)
++-++	rate	0.088 (0, 0.84)	0.11 (0, 0.973)	0.1 (0, 0.324)	0 (0, 0.197)	0 (0, 0.719)	0.124 (0, 0.269)
+++–	graduation	0	8	3	227	230	5
+++–	futility	0	86	99	12	9	102
+++–	max_n	0	0	0	0	0	0
+++–	n	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	n_unique	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
+++–	post_p	NA (NA, NA)	0.46 (0.39, 0.52)	0.48 (0.44, 0.55)	0.56 (0.46, 0.61)	0.54 (0.46, 0.6)	0.5 (0.44, 0.57)
+++–	rate	0.135 (0, 0.549)	0.136 (0, 0.974)	0.153 (0, 1.018)	0 (0, 0.246)	0.068 (0, 0.805)	0.185 (0, 0.574)
+++-+	graduation	0	10	6	232	234	5
+++-+	futility	0	101	116	18	16	119
+++-+	max_n	0	0	0	0	0	0
+++-+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-+	post_p	NA (NA, NA)	0.54 (0.52, 0.58)	0.57 (0.49, 0.58)	0.54 (0.51, 0.58)	0.48 (0.44, 0.52)	NA (NA, NA)
+++-+	rate	0.129 (0, 0.838)	0.11 (0, 0.479)	0.148 (0, 0.746)	0 (0, 0.139)	0.067 (0, 0.467)	0.026 (0, 0.421)
++++-	graduation	0	10	3	231	231	5
++++-	futility	0	89	111	12	12	106
++++-	max_n	0	0	0	0	0	0
++++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++-	post_p	NA (NA, NA)	NA (NA, NA)	0.51 (0.49, 0.51)	0.52 (0.51, 0.54)	NA (NA, NA)	NA (NA, NA)
++++-	rate	0.127 (0, 0.81)	0.104 (0, 0.302)	0.089 (0, 0.386)	0.044 (0, 0.399)	0.075 (0, 0.23)	0.092 (0, 0.561)
+++++	graduation	0	12	6	234	234	5
+++++	futility	0	104	125	18	18	122
+++++	max_n	0	0	0	0	0	0
+++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++++	post_p	NA (NA, NA)	0.48 (0.48, 0.48)	0.51 (0.5, 0.54)	0.5 (0.46, 0.53)	0.5 (0.47, 0.52)	0.49 (0.47, 0.51)
+++++	rate	0.148 (0, 0.413)	0.177 (0.015, 1.408)	0.117 (0, 0.402)	0 (0, 0.229)	0 (0, 0.299)	0.091 (0, 0.891)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count	4	2	4	7	3
all	time_stop	6 (5, 8)	7 (7, 7)	6 (5, 7)	7 (5, 10)	5 (5, 9)
all	n_trt	28 (26, 33)	26 (26, 27)	32 (27, 38)	34 (28, 48)	27 (25, 43)
all	n_control	48 (39, 70)	64 (61, 67)	64 (49, 68)	69 (36, 90)	40 (33, 83)
all	post_p	0.89 (0.87, 0.96)	0.95 (0.92, 0.97)	0.98 (0.96, 0.99)	0.98 (0.95, 1)	0.9 (0.89, 0.98)
all	order	1 (1, 1)	1.5 (1.1, 1.9)	1 (1, 1)	1 (1, 2)	1 (1, 1)
AR- & TP53-	count	13	8	65	62	10
AR- & TP53-	time_stop	11 (9, 13)	12 (10, 18)	14 (10, 26)	14 (9, 27)	14 (11, 17)
AR- & TP53-	n_trt	28 (25, 39)	30 (26, 44)	33 (26, 77)	35 (26, 69)	34 (27, 37)
AR- & TP53-	n_control	60 (47, 78)	71 (50, 103)	73 (51, 158)	78 (48, 146)	72 (42, 89)
AR- & TP53-	post_p	0.92 (0.88, 0.99)	0.94 (0.88, 0.98)	0.98 (0.92, 1)	0.97 (0.88, 1)	0.93 (0.87, 0.99)
AR- & TP53-	order	1 (1, 1)	1 (1, 2)	1 (1, 2)	1 (1, 2)	1 (1, 1.2)
HRD+	count	1		220	219
HRD+	time_stop	36 (36, 36)		30 (24, 35)	30 (24, 35)
HRD+	n_trt	25 (25, 25)		26 (25, 30)	26 (25, 31)
HRD+	n_control	63 (63, 63)		54 (40, 68)	53 (41, 68)
HRD+	post_p	1 (1, 1)		1 (0.99, 1)	1 (0.99, 1)
HRD+	order	2 (2, 2)		2 (1, 2)	1 (1, 2)
TP53+	count	4	2	6	4	3
TP53+	time_stop	18 (16, 22)	24 (22, 26)	21 (16, 24)	22 (17, 31)	18 (16, 24)
TP53+	n_trt	28 (26, 34)	27 (25, 29)	30 (27, 34)	34 (25, 47)	26 (26, 38)
TP53+	n_control	64 (53, 82)	94 (89, 98)	73 (56, 96)	80 (64, 106)	65 (58, 83)
TP53+	post_p	0.96 (0.89, 0.99)	0.97 (0.96, 0.99)	0.97 (0.89, 0.99)	1 (0.99, 1)	0.99 (0.95, 0.99)
TP53+	order	1 (1, 1)	1.5 (1.1, 1.9)	1 (1, 2)	1.5 (1, 2.7)	2 (1.2, 2)
TEfus+	count	2		6	3
TEfus+	time_stop	20 (20, 21)		22 (15, 32)	19 (16, 25)
TEfus+	n_trt	29 (27, 31)		32 (25, 50)	27 (25, 31)
TEfus+	n_control	84 (77, 91)		78 (52, 112)	84 (58, 88)
TEfus+	post_p	0.99 (0.98, 0.99)		0.99 (0.98, 1)	1 (0.89, 1)
TEfus+	order	1 (1, 1)		1 (1, 1.5)	2 (1.2, 2.8)
PI3K+	count	2	3	9	6	1
PI3K+	time_stop	20 (18, 22)	20 (16, 24)	22 (13, 28)	18 (16, 22)	23 (23, 23)
PI3K+	n_trt	31 (29, 33)	32 (26, 34)	30 (26, 35)	29 (25, 30)	32 (32, 32)
PI3K+	n_control	75 (70, 80)	68 (63, 82)	81 (44, 95)	58 (49, 72)	71 (71, 71)
PI3K+	post_p	0.96 (0.93, 0.99)	0.97 (0.89, 0.99)	0.99 (0.98, 1)	0.97 (0.93, 0.99)	0.97 (0.97, 0.97)
PI3K+	order	1.5 (1.1, 1.9)	2 (1.2, 2)	2 (1, 3.2)	1 (1, 2)	1 (1, 1)

Futility:

signature	var	TC1	TC2	TC3	TC4	TC5
all	count		3			5
all	time_stop		8 (6, 14)			10 (6, 14)
all	n_trt		39 (31, 61)			48 (29, 64)
all	n_control		85 (43, 166)			109 (42, 137)
all	post_p		0.04 (0.02, 0.08)			0.05 (0, 0.17)
all	order		1 (1, 1.8)			1 (1, 2.2)
AR- & TP53-	count	77	94	4	10	79
AR- & TP53-	time_stop	15 (9, 32)	15 (9, 30)	11 (10, 11)	12 (9, 16)	15 (10, 33)
AR- & TP53-	n_trt	41 (26, 83)	34 (26, 81)	27 (26, 33)	28 (25, 44)	39 (27, 86)
AR- & TP53-	n_control	86 (46, 184)	86 (47, 174)	58 (55, 60)	61 (39, 87)	83 (52, 197)
AR- & TP53-	post_p	0.14 (0.04, 0.23)	0.11 (0.02, 0.23)	0.11 (0.03, 0.19)	0.16 (0.05, 0.26)	0.1 (0.04, 0.26)
AR- & TP53-	order	1 (1, 3)	1 (1, 3)	1 (1, 1.7)	1 (1, 1.1)	1 (1, 2.2)
HRD+	count	61	67			74
HRD+	time_stop	30 (23, 35)	31 (24, 35)			31 (22, 35)
HRD+	n_trt	26 (25, 34)	26 (25, 33)			26 (25, 33)
HRD+	n_control	52 (36, 64)	57 (44, 69)			54 (39, 65)
HRD+	post_p	0.12 (0.02, 0.24)	0.09 (0.02, 0.22)			0.13 (0.03, 0.25)
HRD+	order	2 (1, 4)	2 (1, 4)			2 (1, 3)
TP53+	count	30	36	14	11	30
TP53+	time_stop	22 (14, 32)	22 (14, 32)	24 (13, 33)	20 (14, 29)	20 (14, 32)
TP53+	n_trt	32 (26, 51)	34 (26, 52)	32 (25, 48)	36 (25, 43)	30 (25, 47)
TP53+	n_control	82 (46, 122)	80 (56, 123)	84 (46, 129)	75 (46, 110)	73 (50, 125)
TP53+	post_p	0.05 (0.02, 0.13)	0.03 (0, 0.16)	0.06 (0.01, 0.17)	0.1 (0.02, 0.2)	0.06 (0.02, 0.18)
TP53+	order	1 (1, 3)	1 (1, 2.5)	1 (1, 2.7)	1 (1, 2)	1.5 (1, 4)
TEfus+	count	8	18	1	3	13
TEfus+	time_stop	23 (16, 31)	22 (16, 33)	16 (16, 16)	30 (25, 30)	20 (15, 24)
TEfus+	n_trt	35 (28, 39)	32 (26, 42)	26 (26, 26)	33 (31, 35)	27 (25, 37)
TEfus+	n_control	76 (58, 107)	71 (53, 127)	62 (62, 62)	108 (94, 121)	67 (50, 90)
TEfus+	post_p	0.03 (0.02, 0.14)	0.05 (0, 0.17)	0.18 (0.18, 0.18)	0.06 (0.02, 0.11)	0.06 (0.01, 0.16)
TEfus+	order	1.5 (1, 3.3)	2 (1, 4)	1 (1, 1)	3 (1.4, 3.8)	2 (1, 3.8)
PI3K+	count	23	24	9	11	30
PI3K+	time_stop	23 (15, 30)	24 (14, 30)	18 (15, 22)	18 (14, 28)	23 (13, 33)
PI3K+	n_trt	33 (25, 47)	28 (25, 45)	31 (25, 37)	27 (26, 33)	30 (26, 44)
PI3K+	n_control	82 (52, 110)	80 (46, 104)	61 (49, 77)	63 (44, 104)	86 (46, 118)
PI3K+	post_p	0.07 (0.01, 0.23)	0.08 (0.01, 0.22)	0.16 (0.02, 0.26)	0.1 (0.04, 0.19)	0.06 (0.02, 0.16)
PI3K+	order	2 (1, 3)	2 (1, 4)	2 (1, 2.2)	1 (1, 2)	2 (1, 4)

By subgroup combinations

Graduation:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC1	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC1	time	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)
all	TC1	n	8 (7, 14)	2 (1, 3)	0 (0, 1)	2 (1, 4)	2 (0, 5)	4 (1, 5)	0 (0, 2)	1 (1, 2)	2 (0, 4)	0 (0, 0)	0 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	2 (1, 2)	2 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.68 (0.6, 0.78)	0.57 (0.56, 0.58)	0.53 (0.53, 0.53)	0.55 (0.54, 0.57)	0.59 (0.55, 0.59)	0.55 (0.52, 0.58)	0.52 (0.52, 0.52)	0.55 (0.51, 0.6)	0.56 (0.56, 0.56)	NA (NA, NA)	0.59 (0.55, 0.64)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.55 (0.53, 0.57)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.54 (0.51, 0.55)	0.53 (0.52, 0.59)	0.52 (0.51, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)	0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.18 (0.18, 0.18)	0.14 (0.14, 0.14)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.049 (0.041, 0.072)	0.147 (0.029, 0.219)	0 (0, 0)	0.042 (0, 1.465)	0 (0, 0.034)	0 (0, 0.063)	0 (0, 0)	0 (0, 13.89)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0.375 (0.375, 0.375)	NA (NA, NA)	NA (NA, NA)	0 (0, 0.104)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
all	TC2	time	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)
all	TC2	n	7 (6, 8)	2 (1, 4)	1 (1, 1)	3 (3, 3)	1 (0, 2)	1 (1, 1)	0 (0, 1)	1 (1, 1)	2 (1, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 2)	0 (0, 1)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	3 (3, 3)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.63 (0.59, 0.66)	0.64 (0.59, 0.69)	0.52 (0.52, 0.52)	0.53 (0.53, 0.53)	0.56 (0.56, 0.56)	0.54 (0.53, 0.54)	0.56 (0.56, 0.56)	0.56 (0.54, 0.58)	0.53 (0.52, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.5 (0.5, 0.5)	0.53 (0.53, 0.53)	NA (NA, NA)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.59 (0.57, 0.61)	0.57 (0.57, 0.57)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)	0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.064 (0.048, 0.08)	0.03 (0.006, 0.055)	0 (0, 0)	0.085 (0.076, 0.094)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.381 (0.206, 0.555)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC3	time	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)
all	TC3	n	8 (6, 11)	2 (1, 2)	0 (0, 1)	2 (1, 2)	2 (1, 4)	2 (0, 3)	0 (0, 1)	1 (0, 3)	3 (1, 5)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 1)	1 (0, 1)	0 (0, 0)	1 (0, 1)	0 (0, 1)	0 (0, 2)	0 (0, 3)	0 (0, 1)	0 (0, 2)	0 (0, 0)	4 (1, 4)	1 (1, 2)	1 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.66 (0.52, 0.83)	0.55 (0.52, 0.58)	0.51 (0.51, 0.51)	0.53 (0.51, 0.54)	0.55 (0.54, 0.55)	0.56 (0.52, 0.63)	0.54 (0.54, 0.54)	0.55 (0.53, 0.56)	0.62 (0.58, 0.67)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	0.51 (0.51, 0.51)	NA (NA, NA)	0.53 (0.52, 0.55)	NA (NA, NA)	0.55 (0.55, 0.55)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.61 (0.58, 0.72)	0.51 (0.5, 0.62)	0.6 (0.58, 0.61)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC3	rate	0.084 (0.049, 0.102)	0 (0, 0.105)	0 (0, 0)	0 (0, 0.132)	0.035 (0, 0.073)	0 (0, 0)	0.413 (0.083, 0.744)	0 (0, 0.126)	0 (0, 0.029)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.376 (0.376, 0.376)	0 (0, 0.309)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.054 (0.011, 0.097)	0 (0, 0)	0.235 (0.201, 0.269)	NA (NA, NA)	0.077 (0.015, 0.084)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	count	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7
all	TC4	time	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)	7 (5, 10)
all	TC4	n	13 (7, 15)	4 (1, 4)	0 (0, 2)	0 (0, 1)	4 (2, 5)	1 (0, 4)	0 (0, 0)	2 (0, 3)	3 (2, 4)	0 (0, 0)	2 (0, 4)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	1 (0, 2)	0 (0, 2)	0 (0, 0)	0 (0, 0)	1 (1, 4)	1 (1, 4)	0 (0, 3)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.73 (0.61, 0.91)	0.59 (0.55, 0.67)	0.52 (0.52, 0.64)	NA (NA, NA)	0.56 (0.51, 0.59)	0.55 (0.53, 0.61)	NA (NA, NA)	0.59 (0.53, 0.67)	0.56 (0.55, 0.7)	NA (NA, NA)	0.63 (0.6, 0.64)	0.56 (0.55, 0.56)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.58 (0.56, 0.64)	0.55 (0.55, 0.55)	NA (NA, NA)	0.53 (0.53, 0.53)	0.61 (0.61, 0.61)	0.56 (0.56, 0.56)	NA (NA, NA)	0.54 (0.53, 0.63)	0.55 (0.54, 0.62)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
all	TC4	rate	0.036 (0, 0.082)	0 (0, 0.061)	0 (0, 0.052)	0 (0, 0)	0.104 (0, 0.167)	0.018 (0, 0.079)	NA (NA, NA)	0.077 (0, 0.151)	0 (0, 0.016)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0.191)	NA (NA, NA)	0 (0, 0.118)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.09)	0 (0, 0.081)	0 (0, 0.12)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
all	TC5	time	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)	5 (5, 9)
all	TC5	n	10 (8, 10)	0 (0, 3)	0 (0, 1)	1 (1, 5)	4 (2, 6)	2 (0, 2)	1 (0, 3)	2 (0, 4)	3 (3, 4)	0 (0, 0)	0 (0, 1)	1 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 2)	0 (0, 0)	0 (0, 0)	2 (1, 3)	2 (2, 3)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	post_p	0.64 (0.56, 0.7)	0.73 (0.73, 0.73)	0.51 (0.51, 0.51)	0.74 (0.6, 0.87)	0.55 (0.53, 0.61)	0.53 (0.53, 0.53)	0.53 (0.53, 0.53)	0.52 (0.52, 0.52)	0.52 (0.51, 0.53)	NA (NA, NA)	NA (NA, NA)	0.6 (0.6, 0.6)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.57 (0.57, 0.57)	NA (NA, NA)	NA (NA, NA)	0.51 (0.51, 0.51)	0.54 (0.54, 0.54)	NA (NA, NA)	NA (NA, NA)	0.53 (0.52, 0.53)	0.55 (0.53, 0.56)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0.062 (0.044, 0.076)	0 (0, 0)	0 (0, 0)	0 (0, 0.025)	0 (0, 0.025)	0.493 (0.188, 0.798)	0 (0, 0)	0.039 (0.008, 0.071)	0 (0, 0.03)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0.139 (0.139, 0.139)	NA (NA, NA)	NA (NA, NA)	0 (0, 0.075)	0 (0, 0.238)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	13	13	13	13					13	13	13	13
AR- & TP53-	TC1	time	11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)					11 (9, 13)	11 (9, 13)	11 (9, 13)	11 (9, 13)
AR- & TP53-	TC1	n	15 (12, 21)	4 (3, 7)	0 (0, 2)	2 (0, 5)					3 (0, 5)	0 (0, 0)	1 (0, 4)	1 (0, 2)
AR- & TP53-	TC1	post_p	0.76 (0.71, 0.83)	0.7 (0.57, 0.81)	0.57 (0.51, 0.6)	0.62 (0.55, 0.76)					0.62 (0.53, 0.73)	NA (NA, NA)	0.58 (0.51, 0.66)	0.55 (0.52, 0.68)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.084 (0.057, 0.104)	0.059 (0.006, 0.097)	0 (0, 0.1)	0.024 (0, 0.084)					0 (0, 0.068)	NA (NA, NA)	0 (0, 0.06)	0.064 (0, 0.3)
AR- & TP53-	TC2	count	8	8	8	8					8	8	8	8
AR- & TP53-	TC2	time	12 (10, 18)	12 (10, 18)	12 (10, 18)	12 (10, 18)					12 (10, 18)	12 (10, 18)	12 (10, 18)	12 (10, 18)
AR- & TP53-	TC2	n	18 (15, 25)	4 (2, 6)	1 (0, 2)	1 (0, 7)					4 (2, 10)	0 (0, 0)	1 (1, 2)	0 (0, 1)
AR- & TP53-	TC2	post_p	0.77 (0.74, 0.84)	0.61 (0.52, 0.75)	0.61 (0.57, 0.65)	0.58 (0.52, 0.7)					0.71 (0.55, 0.81)	NA (NA, NA)	0.53 (0.52, 0.68)	0.56 (0.53, 0.58)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.077 (0.059, 0.094)	0.055 (0, 0.118)	0.049 (0, 0.436)	0.034 (0, 0.113)					0.044 (0, 0.062)	NA (NA, NA)	0 (0, 0.026)	0 (0, 0)
AR- & TP53-	TC3	count	65	65	65	65					65	65	65	65
AR- & TP53-	TC3	time	14 (10, 26)	14 (10, 26)	14 (10, 26)	14 (10, 26)					14 (10, 26)	14 (10, 26)	14 (10, 26)	14 (10, 26)
AR- & TP53-	TC3	n	19 (12, 40)	4 (2, 11)	1 (0, 2)	2 (0, 5)					5 (2, 10)	0 (0, 0)	2 (1, 5)	1 (0, 3)
AR- & TP53-	TC3	post_p	0.79 (0.72, 0.93)	0.67 (0.52, 0.77)	0.57 (0.52, 0.67)	0.59 (0.51, 0.78)					0.77 (0.57, 0.97)	NA (NA, NA)	0.6 (0.53, 0.84)	0.58 (0.53, 0.79)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.081 (0.053, 0.102)	0.078 (0, 0.136)	0 (0, 0.249)	0.055 (0, 0.137)					0.005 (0, 0.052)	0 (0, 0)	0 (0, 0.09)	0 (0, 0.046)
AR- & TP53-	TC4	count	62	62	62	62					62	62	62	62
AR- & TP53-	TC4	time	14 (9, 27)	14 (9, 27)	14 (9, 27)	14 (9, 27)					14 (9, 27)	14 (9, 27)	14 (9, 27)	14 (9, 27)
AR- & TP53-	TC4	n	20 (15, 39)	5 (3, 12)	1 (0, 3)	2 (0, 5)					5 (1, 9)	0 (0, 0)	3 (0, 5)	1 (0, 3)
AR- & TP53-	TC4	post_p	0.82 (0.72, 0.94)	0.66 (0.52, 0.82)	0.55 (0.52, 0.64)	0.58 (0.52, 0.78)					0.7 (0.54, 0.94)	NA (NA, NA)	0.59 (0.53, 0.81)	0.56 (0.52, 0.68)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.072 (0.051, 0.1)	0.066 (0, 0.116)	0.063 (0, 0.222)	0.056 (0, 0.132)					0.02 (0, 0.08)	NA (NA, NA)	0 (0, 0.083)	0 (0, 0.149)
AR- & TP53-	TC5	count	10	10	10	10					10	10	10	10
AR- & TP53-	TC5	time	14 (11, 17)	14 (11, 17)	14 (11, 17)	14 (11, 17)					14 (11, 17)	14 (11, 17)	14 (11, 17)	14 (11, 17)
AR- & TP53-	TC5	n	20 (12, 23)	4 (4, 6)	0 (0, 1)	3 (2, 5)					2 (1, 4)	0 (0, 0)	2 (1, 4)	0 (0, 2)
AR- & TP53-	TC5	post_p	0.78 (0.73, 0.87)	0.74 (0.53, 0.86)	0.61 (0.56, 0.69)	0.54 (0.51, 0.74)					0.57 (0.52, 0.62)	NA (NA, NA)	0.6 (0.53, 0.63)	0.55 (0.54, 0.59)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.085 (0.026, 0.096)	0.071 (0.026, 0.102)	0 (0, 0.073)	0.082 (0, 0.114)					0 (0, 0.139)	1.141 (1.141, 1.141)	0 (0, 0.092)	0.067 (0, 0.307)
HRD+	TC1	count									1	1	1	1	1	1	1	1									1	1	1	1	1	1	1	1
HRD+	TC1	time									36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)									36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
HRD+	TC1	n									11 (11, 11)	0 (0, 0)	3 (3, 3)	6 (6, 6)	0 (0, 0)	1 (1, 1)	0 (0, 0)	1 (1, 1)									3 (3, 3)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.79 (0.79, 0.79)	NA (NA, NA)	0.67 (0.67, 0.67)	0.77 (0.77, 0.77)	NA (NA, NA)	0.58 (0.58, 0.58)	NA (NA, NA)	0.89 (0.89, 0.89)									0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.057 (0.057, 0.057)	NA (NA, NA)	0.066 (0.066, 0.066)	0.019 (0.019, 0.019)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)									0.082 (0.082, 0.082)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	count									220	220	220	220	220	220	220	220									220	220	220	220	220	220	220	220
HRD+	TC3	time									30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)									30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)
HRD+	TC3	n									11 (8, 14)	0 (0, 0)	5 (3, 9)	2 (0, 4)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)									4 (1, 6)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.95 (0.82, 1)	0.53 (0.51, 0.55)	0.83 (0.62, 0.96)	0.65 (0.53, 0.83)	NA (NA, NA)	0.6 (0.52, 0.75)	NA (NA, NA)	0.61 (0.52, 0.76)									0.75 (0.57, 0.93)	0.54 (0.54, 0.54)	0.56 (0.52, 0.62)	NA (NA, NA)	0.54 (0.52, 0.59)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)
HRD+	TC3	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.033 (0.017, 0.053)	0 (0, 2.172)	0.028 (0, 0.068)	0.024 (0, 0.075)	0.024 (0.005, 0.043)	0 (0, 0.083)	0 (0, 0.073)	0 (0, 0.103)									0.026 (0, 0.072)	0 (0, 0.102)	0 (0, 0.105)	0 (0, 0.482)	0 (0, 0.173)	0.087 (0.017, 0.156)	0.058 (0, 0.143)	0 (0, 0.264)
HRD+	TC4	count									219	219	219	219	219	219	219	219									219	219	219	219	219	219	219	219
HRD+	TC4	time									30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)									30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)	30 (24, 35)
HRD+	TC4	n									11 (8, 16)	0 (0, 0)	5 (3, 9)	2 (1, 5)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)									3 (1, 6)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.96 (0.76, 1)	0.56 (0.55, 0.58)	0.82 (0.62, 0.96)	0.68 (0.54, 0.84)	NA (NA, NA)	0.6 (0.52, 0.79)	0.6 (0.6, 0.6)	0.6 (0.52, 0.79)									0.71 (0.56, 0.89)	0.67 (0.67, 0.67)	0.58 (0.51, 0.64)	NA (NA, NA)	0.56 (0.52, 0.58)	NA (NA, NA)	NA (NA, NA)	0.52 (0.52, 0.52)
HRD+	TC4	r_prob									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)									0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.033 (0.014, 0.058)	0 (0, 0.013)	0.031 (0, 0.069)	0.02 (0, 0.072)	0 (0, 0)	0 (0, 0.071)	0 (0, 0.456)	0 (0, 0.095)									0.028 (0, 0.076)	0.027 (0, 0.18)	0 (0, 0.094)	0 (0, 0.388)	0 (0, 0.82)	0.166 (0.033, 0.299)	0.081 (0.016, 0.109)	0 (0, 0.101)
TP53+	TC1	count					4	4	4	4					4	4	4	4					4	4	4	4					4	4	4	4
TP53+	TC1	time					18 (16, 22)	18 (16, 22)	18 (16, 22)	18 (16, 22)					18 (16, 22)	18 (16, 22)	18 (16, 22)	18 (16, 22)					18 (16, 22)	18 (16, 22)	18 (16, 22)	18 (16, 22)					18 (16, 22)	18 (16, 22)	18 (16, 22)	18 (16, 22)
TP53+	TC1	n					5 (5, 7)	8 (4, 10)	0 (0, 2)	5 (3, 5)					0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	6 (4, 7)	4 (3, 6)					0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.71 (0.6, 0.81)	0.8 (0.7, 0.87)	0.58 (0.52, 0.65)	0.56 (0.51, 0.69)					NA (NA, NA)	0.56 (0.56, 0.56)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	0.68 (0.56, 0.82)	0.72 (0.54, 0.87)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.088 (0.069, 0.108)	0.074 (0.05, 0.076)	0.035 (0.007, 0.064)	0.079 (0.035, 0.129)					NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	0.062 (0.035, 0.1)	0.066 (0.013, 0.113)					0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					2	2	2	2					2	2	2	2					2	2	2	2					2	2	2	2
TP53+	TC2	time					24 (22, 26)	24 (22, 26)	24 (22, 26)	24 (22, 26)					24 (22, 26)	24 (22, 26)	24 (22, 26)	24 (22, 26)					24 (22, 26)	24 (22, 26)	24 (22, 26)	24 (22, 26)					24 (22, 26)	24 (22, 26)	24 (22, 26)	24 (22, 26)
TP53+	TC2	n					6 (6, 7)	4 (4, 5)	1 (1, 1)	4 (4, 5)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					1 (0, 2)	0 (0, 0)	4 (4, 5)	5 (5, 5)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.78 (0.76, 0.79)	0.68 (0.54, 0.81)	0.67 (0.57, 0.76)	0.58 (0.53, 0.62)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					0.57 (0.57, 0.57)	NA (NA, NA)	0.8 (0.79, 0.81)	0.61 (0.54, 0.68)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.069 (0.062, 0.076)	0.073 (0.034, 0.112)	0 (0, 0)	0.119 (0.118, 0.12)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)					0.137 (0.137, 0.137)	NA (NA, NA)	0.061 (0.034, 0.088)	0.074 (0.062, 0.086)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					6	6	6	6					6	6	6	6					6	6	6	6					6	6	6	6
TP53+	TC3	time					21 (16, 24)	21 (16, 24)	21 (16, 24)	21 (16, 24)					21 (16, 24)	21 (16, 24)	21 (16, 24)	21 (16, 24)					21 (16, 24)	21 (16, 24)	21 (16, 24)	21 (16, 24)					21 (16, 24)	21 (16, 24)	21 (16, 24)	21 (16, 24)
TP53+	TC3	n					8 (4, 11)	6 (5, 8)	2 (0, 4)	4 (2, 6)					0 (0, 0)	0 (0, 1)	0 (0, 0)	1 (0, 2)					1 (0, 2)	0 (0, 0)	4 (4, 6)	4 (2, 4)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.77 (0.68, 0.82)	0.79 (0.73, 0.88)	0.54 (0.52, 0.63)	0.7 (0.6, 0.77)					NA (NA, NA)	0.63 (0.58, 0.64)	NA (NA, NA)	0.63 (0.6, 0.68)					0.59 (0.59, 0.59)	NA (NA, NA)	0.69 (0.56, 0.78)	0.61 (0.54, 0.72)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.081 (0.04, 0.099)	0.053 (0.039, 0.07)	0.106 (0.026, 0.128)	0.026 (0, 0.091)					0 (0, 0)	0 (0, 0.069)	NA (NA, NA)	0 (0, 0.053)					0.085 (0, 0.228)	NA (NA, NA)	0.07 (0.039, 0.096)	0.058 (0.043, 0.111)					0.173 (0.173, 0.173)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	count					4	4	4	4					4	4	4	4					4	4	4	4					4	4	4	4
TP53+	TC4	time					22 (17, 31)	22 (17, 31)	22 (17, 31)	22 (17, 31)					22 (17, 31)	22 (17, 31)	22 (17, 31)	22 (17, 31)					22 (17, 31)	22 (17, 31)	22 (17, 31)	22 (17, 31)					22 (17, 31)	22 (17, 31)	22 (17, 31)	22 (17, 31)
TP53+	TC4	n					8 (4, 15)	8 (6, 9)	2 (1, 4)	5 (4, 6)					0 (0, 0)	0 (0, 2)	0 (0, 0)	1 (0, 2)					0 (0, 2)	0 (0, 0)	5 (3, 8)	2 (2, 5)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)
TP53+	TC4	post_p					0.75 (0.64, 0.89)	0.85 (0.8, 0.93)	0.59 (0.55, 0.68)	0.71 (0.55, 0.83)					NA (NA, NA)	0.56 (0.52, 0.61)	NA (NA, NA)	0.6 (0.6, 0.6)					0.54 (0.52, 0.56)	NA (NA, NA)	0.66 (0.58, 0.77)	0.77 (0.64, 0.91)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.07 (0.063, 0.09)	0.055 (0.035, 0.088)	0.023 (0, 0.073)	0.086 (0.074, 0.115)					NA (NA, NA)	0.121 (0.024, 0.217)	NA (NA, NA)	0 (0, 0.039)					0.079 (0.065, 0.093)	NA (NA, NA)	0.078 (0.051, 0.098)	0.044 (0.035, 0.053)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.092 (0.092, 0.092)
TP53+	TC5	count					3	3	3	3					3	3	3	3					3	3	3	3					3	3	3	3
TP53+	TC5	time					18 (16, 24)	18 (16, 24)	18 (16, 24)	18 (16, 24)					18 (16, 24)	18 (16, 24)	18 (16, 24)	18 (16, 24)					18 (16, 24)	18 (16, 24)	18 (16, 24)	18 (16, 24)					18 (16, 24)	18 (16, 24)	18 (16, 24)	18 (16, 24)
TP53+	TC5	n					9 (7, 12)	6 (5, 8)	2 (1, 2)	3 (2, 8)					0 (0, 0)	1 (0, 1)	0 (0, 0)	1 (0, 1)					0 (0, 0)	0 (0, 0)	5 (3, 6)	3 (1, 4)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	post_p					0.78 (0.72, 0.85)	0.74 (0.55, 0.77)	0.58 (0.52, 0.61)	0.81 (0.76, 0.82)					NA (NA, NA)	0.6 (0.6, 0.6)	NA (NA, NA)	NA (NA, NA)					NA (NA, NA)	NA (NA, NA)	0.8 (0.62, 0.84)	0.59 (0.57, 0.6)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	r_prob					0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	rate					0.059 (0.038, 0.064)	0.098 (0.066, 0.112)	0.083 (0.017, 0.179)	0.047 (0.009, 0.075)					NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)					NA (NA, NA)	NA (NA, NA)	0.063 (0.048, 0.109)	0.101 (0.02, 0.117)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	count			2	2			2	2			2	2			2	2			2	2			2	2			2	2			2	2
TEfus+	TC1	time			20 (20, 21)	20 (20, 21)			20 (20, 21)	20 (20, 21)			20 (20, 21)	20 (20, 21)			20 (20, 21)	20 (20, 21)			20 (20, 21)	20 (20, 21)			20 (20, 21)	20 (20, 21)			20 (20, 21)	20 (20, 21)			20 (20, 21)	20 (20, 21)
TEfus+	TC1	n			2 (0, 3)	3 (2, 4)			2 (0, 3)	6 (5, 6)			4 (3, 5)	0 (0, 0)			0 (0, 1)	0 (0, 1)			2 (1, 4)	2 (1, 2)			3 (3, 3)	5 (4, 6)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.69 (0.69, 0.69)	0.62 (0.53, 0.71)			0.63 (0.63, 0.63)	0.74 (0.71, 0.77)			0.71 (0.67, 0.75)	NA (NA, NA)			NA (NA, NA)	0.51 (0.51, 0.51)			0.81 (0.73, 0.9)	0.6 (0.56, 0.65)			0.66 (0.56, 0.76)	0.72 (0.69, 0.75)			0.52 (0.52, 0.52)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.07 (0.07, 0.07)	0.115 (0.075, 0.154)			0.082 (0.082, 0.082)	0.055 (0.053, 0.056)			0.052 (0.049, 0.054)	NA (NA, NA)			0.646 (0.646, 0.646)	0.111 (0.111, 0.111)			0.066 (0.027, 0.105)	0 (0, 0)			0.081 (0.039, 0.122)	0.04 (0.032, 0.048)			0.159 (0.159, 0.159)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	count			6	6			6	6			6	6			6	6			6	6			6	6			6	6			6	6
TEfus+	TC3	time			22 (15, 32)	22 (15, 32)			22 (15, 32)	22 (15, 32)			22 (15, 32)	22 (15, 32)			22 (15, 32)	22 (15, 32)			22 (15, 32)	22 (15, 32)			22 (15, 32)	22 (15, 32)			22 (15, 32)	22 (15, 32)			22 (15, 32)	22 (15, 32)
TEfus+	TC3	n			1 (0, 3)	4 (3, 5)			3 (1, 3)	5 (2, 8)			4 (1, 6)	2 (0, 4)			0 (0, 0)	0 (0, 2)			2 (2, 4)	1 (1, 2)			7 (3, 12)	4 (3, 8)			0 (0, 2)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.6 (0.54, 0.8)	0.7 (0.53, 0.76)			0.66 (0.54, 0.79)	0.78 (0.64, 0.89)			0.73 (0.67, 0.94)	0.69 (0.62, 0.84)			NA (NA, NA)	0.54 (0.54, 0.54)			0.6 (0.52, 0.68)	0.59 (0.59, 0.65)			0.71 (0.53, 0.82)	0.74 (0.63, 0.82)			0.58 (0.57, 0.6)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.058 (0.017, 0.127)	0.071 (0.046, 0.106)			0.017 (0, 0.063)	0.062 (0.025, 0.078)			0.023 (0, 0.041)	0 (0, 0.018)			0.041 (0.041, 0.041)	0.048 (0.01, 0.086)			0.065 (0.017, 0.156)	0 (0, 0.092)			0.077 (0.046, 0.126)	0.051 (0, 0.072)			0 (0, 0)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			3	3			3	3			3	3			3	3			3	3			3	3			3	3			3	3
TEfus+	TC4	time			19 (16, 25)	19 (16, 25)			19 (16, 25)	19 (16, 25)			19 (16, 25)	19 (16, 25)			19 (16, 25)	19 (16, 25)			19 (16, 25)	19 (16, 25)			19 (16, 25)	19 (16, 25)			19 (16, 25)	19 (16, 25)			19 (16, 25)	19 (16, 25)
TEfus+	TC4	n			1 (0, 1)	4 (2, 5)			2 (0, 2)	4 (2, 5)			2 (2, 4)	1 (0, 3)			0 (0, 0)	0 (0, 1)			3 (1, 4)	0 (0, 2)			7 (5, 9)	3 (3, 4)			1 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.53 (0.53, 0.53)	0.74 (0.57, 0.77)			0.53 (0.51, 0.56)	0.77 (0.69, 0.78)			0.67 (0.54, 0.92)	0.58 (0.57, 0.59)			NA (NA, NA)	0.54 (0.54, 0.54)			0.62 (0.53, 0.71)	NA (NA, NA)			0.72 (0.56, 0.76)	0.59 (0.54, 0.77)			0.57 (0.57, 0.57)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0 (0, 0)	0.088 (0.018, 0.095)			0.089 (0.018, 0.16)	0 (0, 0.031)			0 (0, 0.043)	0.009 (0.002, 0.016)			NA (NA, NA)	0 (0, 0)			0.083 (0.05, 0.116)	0.118 (0.118, 0.118)			0.094 (0.094, 0.101)	0.055 (0.048, 0.062)			0 (0, 0)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2		2
PI3K+	TC1	time		20 (18, 22)		20 (18, 22)		20 (18, 22)		20 (18, 22)		20 (18, 22)		20 (18, 22)		20 (18, 22)		20 (18, 22)		20 (18, 22)		20 (18, 22)		20 (18, 22)		20 (18, 22)		20 (18, 22)		20 (18, 22)		20 (18, 22)		20 (18, 22)
PI3K+	TC1	n		8 (4, 11)		4 (3, 5)		4 (3, 5)		4 (4, 4)		0 (0, 0)		4 (3, 4)		2 (1, 2)		2 (1, 3)		2 (2, 2)		1 (1, 1)		0 (0, 0)		2 (1, 2)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.79 (0.78, 0.79)		0.55 (0.55, 0.55)		0.87 (0.86, 0.87)		0.66 (0.6, 0.72)		NA (NA, NA)		0.53 (0.51, 0.56)		0.52 (0.52, 0.52)		NA (NA, NA)		0.6 (0.6, 0.6)		0.58 (0.54, 0.61)		NA (NA, NA)		0.69 (0.57, 0.8)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC1	r_prob		0.22 (0.22, 0.22)		0.22 (0.22, 0.22)		0.13 (0.13, 0.13)		0.09 (0.09, 0.09)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.14 (0.14, 0.14)		0.14 (0.14, 0.14)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.045 (0.037, 0.054)		0.087 (0.085, 0.089)		0 (0, 0)		0.088 (0.064, 0.113)		NA (NA, NA)		0.056 (0.029, 0.083)		0.102 (0.02, 0.184)		0.244 (0.239, 0.25)		0.861 (0.245, 1.476)		0.031 (0.006, 0.057)		NA (NA, NA)		0.041 (0.008, 0.074)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	count		3		3		3		3		3		3		3		3		3		3		3		3		3		3		3		3
PI3K+	TC2	time		20 (16, 24)		20 (16, 24)		20 (16, 24)		20 (16, 24)		20 (16, 24)		20 (16, 24)		20 (16, 24)		20 (16, 24)		20 (16, 24)		20 (16, 24)		20 (16, 24)		20 (16, 24)		20 (16, 24)		20 (16, 24)		20 (16, 24)		20 (16, 24)
PI3K+	TC2	n		9 (8, 10)		5 (3, 7)		4 (3, 6)		4 (4, 4)		0 (0, 0)		2 (2, 3)		0 (0, 0)		1 (0, 2)		1 (1, 2)		1 (0, 3)		0 (0, 0)		2 (2, 2)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 1)
PI3K+	TC2	post_p		0.75 (0.72, 0.81)		0.57 (0.57, 0.75)		0.73 (0.57, 0.84)		0.56 (0.51, 0.8)		NA (NA, NA)		0.6 (0.54, 0.66)		NA (NA, NA)		0.62 (0.53, 0.71)		0.66 (0.58, 0.73)		0.52 (0.52, 0.54)		NA (NA, NA)		0.66 (0.65, 0.82)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.057 (0.049, 0.063)		0.097 (0.063, 0.117)		0.043 (0.009, 0.085)		0.095 (0.054, 0.102)		NA (NA, NA)		0 (0, 0.208)		NA (NA, NA)		0.228 (0.137, 0.318)		0 (0, 0.032)		0.081 (0.016, 0.146)		NA (NA, NA)		0.042 (0.008, 0.047)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0 (0, 0)
PI3K+	TC3	count		9		9		9		9		9		9		9		9		9		9		9		9		9		9		9		9
PI3K+	TC3	time		22 (13, 28)		22 (13, 28)		22 (13, 28)		22 (13, 28)		22 (13, 28)		22 (13, 28)		22 (13, 28)		22 (13, 28)		22 (13, 28)		22 (13, 28)		22 (13, 28)		22 (13, 28)		22 (13, 28)		22 (13, 28)		22 (13, 28)		22 (13, 28)
PI3K+	TC3	n		6 (4, 9)		4 (3, 6)		7 (5, 8)		4 (3, 6)		0 (0, 0)		1 (0, 3)		1 (0, 2)		0 (0, 2)		0 (0, 1)		1 (1, 2)		0 (0, 0)		3 (2, 6)		0 (0, 0)		0 (0, 1)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	post_p		0.73 (0.54, 0.87)		0.64 (0.59, 0.71)		0.76 (0.68, 0.86)		0.76 (0.63, 0.85)		NA (NA, NA)		0.6 (0.55, 0.69)		0.6 (0.57, 0.67)		0.67 (0.64, 0.71)		0.56 (0.54, 0.58)		0.57 (0.53, 0.72)		NA (NA, NA)		0.69 (0.61, 0.83)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.064 (0.032, 0.11)		0.055 (0.032, 0.091)		0.066 (0.033, 0.104)		0.054 (0.047, 0.074)		0 (0, 0)		0 (0, 0.06)		0 (0, 0.035)		0 (0, 0.067)		0.025 (0, 0.055)		0 (0, 0.081)		NA (NA, NA)		0.053 (0, 0.099)		0 (0, 0)		0 (0, 0)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	count		6		6		6		6		6		6		6		6		6		6		6		6		6		6		6		6
PI3K+	TC4	time		18 (16, 22)		18 (16, 22)		18 (16, 22)		18 (16, 22)		18 (16, 22)		18 (16, 22)		18 (16, 22)		18 (16, 22)		18 (16, 22)		18 (16, 22)		18 (16, 22)		18 (16, 22)		18 (16, 22)		18 (16, 22)		18 (16, 22)		18 (16, 22)
PI3K+	TC4	n		5 (4, 8)		4 (2, 5)		6 (4, 8)		4 (2, 5)		0 (0, 0)		2 (2, 4)		0 (0, 2)		0 (0, 1)		1 (0, 1)		0 (0, 2)		0 (0, 0)		4 (2, 5)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC4	post_p		0.66 (0.52, 0.85)		0.64 (0.53, 0.71)		0.65 (0.55, 0.75)		0.59 (0.54, 0.7)		NA (NA, NA)		0.54 (0.51, 0.77)		0.6 (0.58, 0.69)		0.58 (0.58, 0.58)		0.53 (0.51, 0.54)		0.57 (0.57, 0.57)		NA (NA, NA)		0.7 (0.54, 0.89)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.074 (0.053, 0.119)		0.074 (0.023, 0.096)		0.08 (0.063, 0.088)		0.08 (0, 0.103)		NA (NA, NA)		0.033 (0.028, 0.126)		0 (0, 0.129)		0 (0, 0)		0 (0, 0)		0.245 (0.13, 0.359)		NA (NA, NA)		0.053 (0.01, 0.095)		NA (NA, NA)		NA (NA, NA)		0 (0, 0)		NA (NA, NA)
PI3K+	TC5	count		1		1		1		1		1		1		1		1		1		1		1		1		1		1		1		1
PI3K+	TC5	time		23 (23, 23)		23 (23, 23)		23 (23, 23)		23 (23, 23)		23 (23, 23)		23 (23, 23)		23 (23, 23)		23 (23, 23)		23 (23, 23)		23 (23, 23)		23 (23, 23)		23 (23, 23)		23 (23, 23)		23 (23, 23)		23 (23, 23)		23 (23, 23)
PI3K+	TC5	n		5 (5, 5)		5 (5, 5)		7 (7, 7)		7 (7, 7)		0 (0, 0)		2 (2, 2)		1 (1, 1)		0 (0, 0)		1 (1, 1)		1 (1, 1)		0 (0, 0)		3 (3, 3)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	post_p		0.51 (0.51, 0.51)		0.84 (0.84, 0.84)		0.83 (0.83, 0.83)		0.87 (0.87, 0.87)		NA (NA, NA)		0.51 (0.51, 0.51)		NA (NA, NA)		NA (NA, NA)		0.56 (0.56, 0.56)		NA (NA, NA)		NA (NA, NA)		0.6 (0.6, 0.6)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	r_prob		0.38 (0.38, 0.38)		0.38 (0.38, 0.38)		0.33 (0.33, 0.33)		0.38 (0.38, 0.38)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	rate		0.137 (0.137, 0.137)		0.047 (0.047, 0.047)		0.051 (0.051, 0.051)		0.069 (0.069, 0.069)		NA (NA, NA)		0.098 (0.098, 0.098)		0.15 (0.15, 0.15)		NA (NA, NA)		0 (0, 0)		0 (0, 0)		NA (NA, NA)		0.067 (0.067, 0.067)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)

Futility:

signature	treatment	var	—–	—-+	—+-	—++	–+–	–+-+	–++-	–+++	-+—	-+–+	-+-+-	-+-++	-++–	-++-+	-+++-	-++++	+—-	+—+	+–+-	+–++	+-+–	+-+-+	+-++-	+-+++	++—	++–+	++-+-	++-++	+++–	+++-+	++++-	+++++
all	TC2	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
all	TC2	time	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)	8 (6, 14)
all	TC2	n	11 (8, 14)	3 (2, 3)	0 (0, 2)	2 (0, 3)	2 (0, 6)	3 (2, 4)	1 (1, 2)	2 (1, 2)	3 (1, 5)	0 (0, 1)	2 (0, 6)	1 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 2)	1 (0, 3)	0 (0, 1)	2 (0, 2)	0 (0, 1)	0 (0, 2)	0 (0, 0)	4 (2, 6)	1 (0, 2)	1 (0, 3)	0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.4 (0.25, 0.47)	0.39 (0.36, 0.4)	NA (NA, NA)	0.25 (0.21, 0.28)	0.27 (0.2, 0.33)	0.41 (0.34, 0.46)	0.4 (0.31, 0.46)	0.39 (0.36, 0.45)	0.34 (0.34, 0.34)	NA (NA, NA)	0.37 (0.32, 0.42)	NA (NA, NA)	NA (NA, NA)	0.43 (0.43, 0.43)	NA (NA, NA)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	NA (NA, NA)	0.46 (0.46, 0.46)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.44 (0.28, 0.48)	0.49 (0.49, 0.49)	0.48 (0.47, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)	0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.41 (0.41, 0.41)	0.29 (0.29, 0.29)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.133 (0.12, 0.147)	0.293 (0.238, 0.344)	0.969 (0.969, 0.969)	0.507 (0.34, 0.673)	0.313 (0.239, 0.386)	0.114 (0.105, 0.403)	0.439 (0.431, 0.503)	0.153 (0.131, 0.471)	0.192 (0.128, 0.257)	0 (0, 0)	0.157 (0.137, 0.177)	0 (0, 0)	NA (NA, NA)	1.537 (1.537, 1.537)	NA (NA, NA)	0.432 (0.432, 0.432)	0.068 (0.014, 0.123)	0 (0, 0)	0.251 (0.05, 0.451)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0.247 (0.183, 0.283)	0.264 (0.246, 0.282)	0.039 (0.008, 0.071)	NA (NA, NA)	0.165 (0.163, 0.167)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
all	TC5	time	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)	10 (6, 14)
all	TC5	n	13 (4, 15)	4 (3, 6)	1 (0, 2)	1 (0, 4)	7 (2, 11)	4 (2, 7)	0 (0, 1)	2 (1, 4)	4 (3, 5)	0 (0, 0)	1 (0, 3)	1 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 2)	0 (0, 2)	0 (0, 1)	0 (0, 1)	4 (1, 5)	2 (1, 3)	1 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	post_p	0.25 (0.06, 0.46)	0.38 (0.29, 0.4)	0.31 (0.31, 0.31)	0.4 (0.34, 0.45)	0.46 (0.41, 0.48)	0.23 (0.13, 0.39)	0.43 (0.42, 0.43)	0.34 (0.26, 0.45)	0.43 (0.3, 0.48)	NA (NA, NA)	0.45 (0.36, 0.48)	0.47 (0.47, 0.47)	NA (NA, NA)	0.49 (0.49, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.5 (0.5, 0.5)	0.38 (0.38, 0.38)	NA (NA, NA)	NA (NA, NA)	0.38 (0.33, 0.41)	0.42 (0.36, 0.48)	0.44 (0.44, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)	0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC5	rate	0.176 (0.129, 0.221)	0.208 (0.128, 0.253)	0.286 (0.2, 0.582)	0.365 (0.121, 0.811)	0.089 (0.059, 0.123)	0.222 (0.121, 0.393)	0.525 (0.221, 0.83)	0.33 (0.195, 0.513)	0.129 (0.118, 0.345)	NA (NA, NA)	0.187 (0.037, 0.204)	0 (0, 0.17)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0.166 (0.157, 0.176)	NA (NA, NA)	0 (0, 0)	0.296 (0.153, 0.439)	0.221 (0.221, 0.221)	0.068 (0.068, 0.068)	0.209 (0.124, 0.282)	0.17 (0.104, 0.453)	0.119 (0.116, 0.397)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
AR- & TP53-	TC1	count	77	77	77	77					77	77	77	77
AR- & TP53-	TC1	time	15 (9, 32)	15 (9, 32)	15 (9, 32)	15 (9, 32)					15 (9, 32)	15 (9, 32)	15 (9, 32)	15 (9, 32)
AR- & TP53-	TC1	n	21 (14, 47)	6 (3, 13)	1 (0, 3)	3 (0, 7)					6 (3, 11)	0 (0, 0)	3 (1, 5)	1 (0, 3)
AR- & TP53-	TC1	post_p	0.34 (0.13, 0.47)	0.4 (0.22, 0.48)	0.43 (0.35, 0.48)	0.41 (0.24, 0.48)					0.38 (0.14, 0.48)	NA (NA, NA)	0.41 (0.23, 0.49)	0.43 (0.33, 0.48)
AR- & TP53-	TC1	r_prob	0.41 (0.41, 0.41)	0.22 (0.22, 0.22)	0.37 (0.37, 0.37)	0.22 (0.22, 0.22)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC1	rate	0.124 (0.106, 0.166)	0.15 (0.103, 0.266)	0.282 (0.093, 0.961)	0.174 (0.112, 0.363)					0.146 (0.082, 0.261)	0.119 (0.119, 0.119)	0.165 (0.09, 0.407)	0.143 (0.012, 0.601)
AR- & TP53-	TC2	count	94	94	94	94					94	94	94	94
AR- & TP53-	TC2	time	15 (9, 30)	15 (9, 30)	15 (9, 30)	15 (9, 30)					15 (9, 30)	15 (9, 30)	15 (9, 30)	15 (9, 30)
AR- & TP53-	TC2	n	19 (14, 44)	5 (2, 13)	1 (0, 3)	3 (0, 7)					5 (2, 10)	0 (0, 0)	2 (0, 7)	1 (0, 3)
AR- & TP53-	TC2	post_p	0.31 (0.1, 0.45)	0.39 (0.23, 0.47)	0.44 (0.37, 0.5)	0.41 (0.26, 0.49)					0.38 (0.16, 0.48)	NA (NA, NA)	0.41 (0.23, 0.49)	0.41 (0.32, 0.47)
AR- & TP53-	TC2	r_prob	0.18 (0.18, 0.18)	0.03 (0.03, 0.03)	0.25 (0.25, 0.25)	0.03 (0.03, 0.03)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC2	rate	0.133 (0.112, 0.172)	0.152 (0.099, 0.304)	0.186 (0.08, 0.588)	0.189 (0.102, 0.511)					0.132 (0.084, 0.349)	NA (NA, NA)	0.161 (0.081, 0.458)	0.209 (0.035, 0.702)
AR- & TP53-	TC3	count	4	4	4	4					4	4	4	4
AR- & TP53-	TC3	time	11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)					11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)
AR- & TP53-	TC3	n	14 (11, 18)	4 (4, 6)	0 (0, 1)	3 (2, 4)					3 (2, 4)	0 (0, 0)	2 (1, 4)	0 (0, 2)
AR- & TP53-	TC3	post_p	0.31 (0.27, 0.34)	0.22 (0.14, 0.31)	NA (NA, NA)	0.44 (0.39, 0.49)					0.46 (0.38, 0.49)	NA (NA, NA)	0.41 (0.34, 0.48)	NA (NA, NA)
AR- & TP53-	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC3	rate	0.119 (0.107, 0.137)	0.321 (0.227, 0.498)	0 (0, 0)	0.143 (0.126, 0.165)					0.141 (0.078, 0.544)	NA (NA, NA)	0.128 (0.085, 1.444)	0 (0, 0)
AR- & TP53-	TC4	count	10	10	10	10					10	10	10	10
AR- & TP53-	TC4	time	12 (9, 16)	12 (9, 16)	12 (9, 16)	12 (9, 16)					12 (9, 16)	12 (9, 16)	12 (9, 16)	12 (9, 16)
AR- & TP53-	TC4	n	18 (11, 20)	4 (2, 8)	0 (0, 3)	1 (1, 5)					3 (2, 6)	0 (0, 0)	2 (0, 4)	1 (0, 2)
AR- & TP53-	TC4	post_p	0.37 (0.17, 0.45)	0.36 (0.16, 0.44)	0.47 (0.45, 0.49)	0.41 (0.36, 0.46)					0.45 (0.42, 0.48)	NA (NA, NA)	0.43 (0.38, 0.46)	0.42 (0.41, 0.45)
AR- & TP53-	TC4	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
AR- & TP53-	TC4	rate	0.127 (0.111, 0.236)	0.176 (0.149, 0.343)	0.262 (0.067, 0.637)	0.277 (0.114, 2.013)					0.14 (0.09, 0.176)	NA (NA, NA)	0.135 (0.081, 0.193)	0.157 (0, 0.256)
AR- & TP53-	TC5	count	79	79	79	79					79	79	79	79
AR- & TP53-	TC5	time	15 (10, 33)	15 (10, 33)	15 (10, 33)	15 (10, 33)					15 (10, 33)	15 (10, 33)	15 (10, 33)	15 (10, 33)
AR- & TP53-	TC5	n	23 (14, 47)	6 (2, 14)	1 (0, 3)	3 (1, 7)					6 (2, 12)	0 (0, 0)	2 (0, 7)	1 (0, 4)
AR- & TP53-	TC5	post_p	0.3 (0.08, 0.47)	0.35 (0.19, 0.47)	0.43 (0.34, 0.49)	0.4 (0.24, 0.48)					0.33 (0.18, 0.48)	NA (NA, NA)	0.39 (0.23, 0.48)	0.42 (0.36, 0.47)
AR- & TP53-	TC5	r_prob	0 (0, 0)	0.38 (0.38, 0.38)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
AR- & TP53-	TC5	rate	0.13 (0.105, 0.165)	0.153 (0.1, 0.311)	0.183 (0.085, 0.405)	0.179 (0.107, 0.43)					0.145 (0.084, 0.376)	0.355 (0.355, 0.355)	0.16 (0.077, 0.269)	0.204 (0.06, 0.888)
HRD+	TC1	count									61	61	61	61	61	61	61	61									61	61	61	61	61	61	61	61
HRD+	TC1	time									30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)									30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)
HRD+	TC1	n									11 (8, 17)	0 (0, 0)	6 (3, 9)	3 (1, 5)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)									3 (2, 6)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.24 (0.1, 0.47)	NA (NA, NA)	0.34 (0.15, 0.46)	0.42 (0.28, 0.49)	0.5 (0.5, 0.5)	0.42 (0.34, 0.48)	NA (NA, NA)	0.4 (0.36, 0.48)									0.37 (0.2, 0.47)	NA (NA, NA)	0.43 (0.42, 0.48)	NA (NA, NA)	0.47 (0.47, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.13 (0.096, 0.182)	0.651 (0.651, 0.651)	0.15 (0.104, 0.277)	0.166 (0.056, 0.557)	0.199 (0.157, 0.24)	0.189 (0.067, 0.853)	0.747 (0.747, 0.747)	0.191 (0.083, 0.483)									0.146 (0.077, 0.32)	0.166 (0.166, 0.166)	0.207 (0.068, 0.742)	0.087 (0.017, 0.156)	0.239 (0, 4.669)	0.13 (0.13, 0.13)	0.139 (0.065, 0.282)	NA (NA, NA)
HRD+	TC2	count									67	67	67	67	67	67	67	67									67	67	67	67	67	67	67	67
HRD+	TC2	time									31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)									31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)	31 (24, 35)
HRD+	TC2	n									12 (8, 14)	0 (0, 0)	6 (2, 9)	2 (1, 4)	0 (0, 0)	1 (0, 3)	0 (0, 0)	2 (0, 3)									4 (2, 6)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.22 (0.05, 0.42)	NA (NA, NA)	0.32 (0.16, 0.45)	0.42 (0.27, 0.48)	0.45 (0.45, 0.45)	0.42 (0.28, 0.49)	NA (NA, NA)	0.42 (0.31, 0.47)									0.35 (0.17, 0.49)	NA (NA, NA)	0.43 (0.38, 0.48)	NA (NA, NA)	0.46 (0.44, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.133 (0.097, 0.205)	0.077 (0.077, 0.077)	0.146 (0.097, 0.26)	0.152 (0.08, 0.845)	0.368 (0.319, 0.417)	0.172 (0.085, 0.579)	0.268 (0.096, 0.44)	0.159 (0.062, 0.433)									0.132 (0.088, 0.381)	0.158 (0.158, 0.158)	0.225 (0.051, 0.516)	0.055 (0.011, 0.1)	0.154 (0, 1.883)	0.072 (0.014, 0.13)	0.098 (0.083, 0.117)	0.169 (0.107, 0.231)
HRD+	TC5	count									74	74	74	74	74	74	74	74									74	74	74	74	74	74	74	74
HRD+	TC5	time									31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)									31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)	31 (22, 35)
HRD+	TC5	n									12 (9, 15)	0 (0, 0)	5 (3, 9)	3 (0, 4)	0 (0, 0)	1 (0, 3)	0 (0, 0)	1 (0, 3)									4 (2, 6)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	post_p									0.23 (0.09, 0.42)	NA (NA, NA)	0.38 (0.19, 0.47)	0.41 (0.29, 0.48)	NA (NA, NA)	0.41 (0.33, 0.47)	NA (NA, NA)	0.44 (0.29, 0.48)									0.35 (0.21, 0.48)	NA (NA, NA)	0.44 (0.41, 0.49)	NA (NA, NA)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
HRD+	TC5	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC5	rate									0.129 (0.096, 0.183)	5.755 (1.343, 9.428)	0.131 (0.089, 0.22)	0.133 (0.078, 0.691)	0.21 (0.042, 0.413)	0.186 (0.071, 0.95)	0 (0, 0.134)	0.164 (0.068, 0.493)									0.154 (0.083, 0.345)	0.197 (0.167, 0.22)	0.122 (0, 1.938)	0.106 (0.106, 0.106)	0.151 (0.047, 0.395)	0.051 (0.01, 0.102)	NA (NA, NA)	0.081 (0.06, 0.103)
TP53+	TC1	count					30	30	30	30					30	30	30	30					30	30	30	30					30	30	30	30
TP53+	TC1	time					22 (14, 32)	22 (14, 32)	22 (14, 32)	22 (14, 32)					22 (14, 32)	22 (14, 32)	22 (14, 32)	22 (14, 32)					22 (14, 32)	22 (14, 32)	22 (14, 32)	22 (14, 32)					22 (14, 32)	22 (14, 32)	22 (14, 32)	22 (14, 32)
TP53+	TC1	n					6 (4, 12)	7 (4, 11)	2 (0, 4)	5 (2, 9)					0 (0, 0)	0 (0, 3)	0 (0, 0)	1 (0, 2)					0 (0, 1)	0 (0, 0)	5 (4, 8)	4 (2, 7)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.24 (0.17, 0.41)	0.35 (0.22, 0.49)	0.41 (0.27, 0.46)	0.4 (0.23, 0.47)					0.46 (0.46, 0.46)	0.41 (0.27, 0.46)	NA (NA, NA)	0.42 (0.33, 0.48)					0.45 (0.4, 0.47)	NA (NA, NA)	0.39 (0.16, 0.49)	0.43 (0.2, 0.45)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.31 (0.31, 0.31)	0.13 (0.13, 0.13)	0.18 (0.18, 0.18)	0.09 (0.09, 0.09)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.12 (0.12, 0.12)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.07 (0.07, 0.07)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.179 (0.129, 0.332)	0.151 (0.096, 0.266)	0.233 (0.103, 0.551)	0.143 (0.114, 0.252)					0.238 (0.165, 0.312)	0.182 (0.061, 0.295)	NA (NA, NA)	0.155 (0.036, 0.364)					0.234 (0.082, 3.127)	0.212 (0.212, 0.212)	0.15 (0.107, 0.243)	0.146 (0.098, 0.394)					0.153 (0.031, 0.625)	0.288 (0.288, 0.288)	NA (NA, NA)	0 (0, 0)
TP53+	TC2	count					36	36	36	36					36	36	36	36					36	36	36	36					36	36	36	36
TP53+	TC2	time					22 (14, 32)	22 (14, 32)	22 (14, 32)	22 (14, 32)					22 (14, 32)	22 (14, 32)	22 (14, 32)	22 (14, 32)					22 (14, 32)	22 (14, 32)	22 (14, 32)	22 (14, 32)					22 (14, 32)	22 (14, 32)	22 (14, 32)	22 (14, 32)
TP53+	TC2	n					7 (4, 12)	6 (4, 10)	2 (0, 5)	5 (2, 10)					0 (0, 0)	1 (0, 2)	0 (0, 0)	1 (0, 2)					0 (0, 2)	0 (0, 0)	6 (4, 10)	5 (2, 9)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.27 (0.1, 0.44)	0.4 (0.15, 0.48)	0.4 (0.28, 0.47)	0.37 (0.2, 0.49)					NA (NA, NA)	0.43 (0.32, 0.49)	NA (NA, NA)	0.43 (0.32, 0.49)					0.44 (0.4, 0.46)	NA (NA, NA)	0.35 (0.13, 0.48)	0.35 (0.15, 0.47)					0.46 (0.46, 0.46)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)
TP53+	TC2	r_prob					0.17 (0.17, 0.17)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.16 (0.16, 0.16)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0.37 (0.37, 0.37)	0.21 (0.21, 0.21)	0.37 (0.37, 0.37)	0.21 (0.21, 0.21)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.169 (0.125, 0.251)	0.149 (0.104, 0.232)	0.24 (0.095, 0.482)	0.141 (0.097, 0.437)					2.968 (2.968, 2.968)	0.188 (0.029, 0.833)	NA (NA, NA)	0.193 (0, 0.53)					0.226 (0.112, 1.173)	NA (NA, NA)	0.157 (0.121, 0.228)	0.171 (0.117, 0.369)					0.249 (0.149, 0.36)	0.144 (0.144, 0.144)	0.08 (0.078, 1.011)	NA (NA, NA)
TP53+	TC3	count					14	14	14	14					14	14	14	14					14	14	14	14					14	14	14	14
TP53+	TC3	time					24 (13, 33)	24 (13, 33)	24 (13, 33)	24 (13, 33)					24 (13, 33)	24 (13, 33)	24 (13, 33)	24 (13, 33)					24 (13, 33)	24 (13, 33)	24 (13, 33)	24 (13, 33)					24 (13, 33)	24 (13, 33)	24 (13, 33)	24 (13, 33)
TP53+	TC3	n					9 (5, 14)	6 (4, 11)	2 (0, 3)	4 (2, 11)					0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 3)					0 (0, 2)	0 (0, 0)	4 (4, 10)	4 (1, 6)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.44 (0.21, 0.48)	0.33 (0.14, 0.48)	0.37 (0.28, 0.48)	0.35 (0.1, 0.39)					NA (NA, NA)	0.41 (0.37, 0.46)	NA (NA, NA)	0.45 (0.43, 0.46)					0.42 (0.41, 0.47)	NA (NA, NA)	0.32 (0.21, 0.43)	0.36 (0.21, 0.47)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.135 (0.114, 0.179)	0.166 (0.104, 0.295)	0.231 (0.135, 4.249)	0.19 (0.142, 0.438)					NA (NA, NA)	0.171 (0.094, 3.996)	NA (NA, NA)	0.1 (0.088, 2.893)					0.313 (0.093, 0.445)	NA (NA, NA)	0.19 (0.138, 0.328)	0.168 (0.117, 0.365)					0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)
TP53+	TC4	count					11	11	11	11					11	11	11	11					11	11	11	11					11	11	11	11
TP53+	TC4	time					20 (14, 29)	20 (14, 29)	20 (14, 29)	20 (14, 29)					20 (14, 29)	20 (14, 29)	20 (14, 29)	20 (14, 29)					20 (14, 29)	20 (14, 29)	20 (14, 29)	20 (14, 29)					20 (14, 29)	20 (14, 29)	20 (14, 29)	20 (14, 29)
TP53+	TC4	n					7 (3, 8)	8 (4, 13)	2 (1, 3)	6 (4, 10)					0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 2)					0 (0, 1)	0 (0, 0)	6 (3, 10)	3 (1, 6)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)
TP53+	TC4	post_p					0.44 (0.25, 0.48)	0.29 (0.23, 0.48)	0.36 (0.34, 0.47)	0.34 (0.27, 0.48)					NA (NA, NA)	0.46 (0.42, 0.48)	NA (NA, NA)	0.43 (0.43, 0.43)					0.47 (0.47, 0.47)	NA (NA, NA)	0.32 (0.16, 0.41)	0.37 (0.17, 0.49)					NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.43 (0.43, 0.43)
TP53+	TC4	r_prob					0.07 (0.07, 0.07)	0.07 (0.07, 0.07)	0 (0, 0)	0 (0, 0)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.06 (0.06, 0.06)	0.07 (0.07, 0.07)	0.06 (0.06, 0.06)	0.07 (0.07, 0.07)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.141 (0.102, 0.228)	0.152 (0.131, 0.177)	0.174 (0.073, 0.294)	0.137 (0.109, 0.262)					NA (NA, NA)	0.199 (0.079, 0.387)	NA (NA, NA)	0.103 (0.015, 0.229)					0.142 (0.093, 3.857)	NA (NA, NA)	0.177 (0.124, 0.211)	0.162 (0.114, 0.52)					0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0.326 (0.065, 0.586)
TP53+	TC5	count					30	30	30	30					30	30	30	30					30	30	30	30					30	30	30	30
TP53+	TC5	time					20 (14, 32)	20 (14, 32)	20 (14, 32)	20 (14, 32)					20 (14, 32)	20 (14, 32)	20 (14, 32)	20 (14, 32)					20 (14, 32)	20 (14, 32)	20 (14, 32)	20 (14, 32)					20 (14, 32)	20 (14, 32)	20 (14, 32)	20 (14, 32)
TP53+	TC5	n					7 (5, 12)	7 (4, 10)	2 (0, 4)	5 (2, 10)					0 (0, 0)	1 (0, 2)	0 (0, 0)	0 (0, 2)					0 (0, 1)	0 (0, 0)	6 (3, 8)	4 (1, 8)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	post_p					0.35 (0.11, 0.44)	0.33 (0.13, 0.49)	0.42 (0.25, 0.48)	0.36 (0.24, 0.49)					NA (NA, NA)	0.42 (0.37, 0.47)	NA (NA, NA)	0.44 (0.34, 0.49)					0.48 (0.39, 0.48)	NA (NA, NA)	0.34 (0.21, 0.48)	0.4 (0.21, 0.49)					0.49 (0.49, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TP53+	TC5	r_prob					0.07 (0.07, 0.07)	0.33 (0.33, 0.33)	0 (0, 0)	0.38 (0.38, 0.38)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0.29 (0.29, 0.29)	0 (0, 0)	0.29 (0.29, 0.29)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC5	rate					0.143 (0.102, 0.274)	0.18 (0.109, 0.262)	0.181 (0.106, 0.538)	0.163 (0.107, 0.312)					0.091 (0.018, 0.164)	0.194 (0.099, 1.132)	NA (NA, NA)	0.167 (0.011, 0.32)					0.249 (0.077, 0.887)	0.234 (0.102, 0.367)	0.172 (0.102, 0.291)	0.162 (0.096, 0.29)					0.174 (0.14, 0.207)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	count			8	8			8	8			8	8			8	8			8	8			8	8			8	8			8	8
TEfus+	TC1	time			23 (16, 31)	23 (16, 31)			23 (16, 31)	23 (16, 31)			23 (16, 31)	23 (16, 31)			23 (16, 31)	23 (16, 31)			23 (16, 31)	23 (16, 31)			23 (16, 31)	23 (16, 31)			23 (16, 31)	23 (16, 31)			23 (16, 31)	23 (16, 31)
TEfus+	TC1	n			0 (0, 3)	4 (2, 6)			2 (1, 4)	6 (4, 8)			4 (2, 6)	2 (1, 2)			0 (0, 0)	1 (0, 2)			3 (2, 4)	1 (0, 2)			5 (3, 10)	4 (3, 5)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.44 (0.43, 0.46)	0.44 (0.26, 0.48)			0.42 (0.32, 0.47)	0.29 (0.18, 0.45)			0.41 (0.32, 0.45)	0.4 (0.26, 0.46)			NA (NA, NA)	0.48 (0.43, 0.49)			0.37 (0.24, 0.47)	0.44 (0.28, 0.46)			0.31 (0.17, 0.46)	0.33 (0.18, 0.45)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.37 (0.37, 0.37)	0.22 (0.22, 0.22)			0.18 (0.18, 0.18)	0.09 (0.09, 0.09)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.18 (0.18, 0.18)	0.14 (0.14, 0.14)			0.12 (0.12, 0.12)	0.07 (0.07, 0.07)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.247 (0.087, 0.256)	0.118 (0.101, 0.325)			0.172 (0.12, 0.526)	0.19 (0.098, 0.246)			0.164 (0.127, 0.233)	0.232 (0.111, 0.326)			NA (NA, NA)	0.099 (0.035, 0.153)			0.193 (0.112, 0.309)	0.337 (0.157, 0.631)			0.163 (0.116, 0.24)	0.24 (0.119, 0.328)			0.07 (0.07, 0.07)	NA (NA, NA)			NA (NA, NA)	0 (0, 0)
TEfus+	TC2	count			18	18			18	18			18	18			18	18			18	18			18	18			18	18			18	18
TEfus+	TC2	time			22 (16, 33)	22 (16, 33)			22 (16, 33)	22 (16, 33)			22 (16, 33)	22 (16, 33)			22 (16, 33)	22 (16, 33)			22 (16, 33)	22 (16, 33)			22 (16, 33)	22 (16, 33)			22 (16, 33)	22 (16, 33)			22 (16, 33)	22 (16, 33)
TEfus+	TC2	n			1 (0, 2)	3 (2, 5)			2 (0, 4)	6 (2, 8)			4 (1, 8)	2 (0, 3)			0 (0, 0)	1 (0, 2)			2 (0, 4)	1 (0, 3)			6 (4, 11)	5 (2, 7)			0 (0, 2)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.44 (0.36, 0.49)	0.39 (0.16, 0.48)			0.44 (0.32, 0.49)	0.39 (0.15, 0.46)			0.36 (0.1, 0.47)	0.4 (0.37, 0.45)			NA (NA, NA)	0.39 (0.3, 0.47)			0.43 (0.37, 0.48)	0.4 (0.31, 0.46)			0.42 (0.23, 0.47)	0.39 (0.27, 0.47)			0.47 (0.42, 0.49)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.25 (0.25, 0.25)	0.03 (0.03, 0.03)			0.41 (0.41, 0.41)	0.16 (0.16, 0.16)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.41 (0.41, 0.41)	0.29 (0.29, 0.29)			0.37 (0.37, 0.37)	0.21 (0.21, 0.21)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.168 (0.129, 0.28)	0.148 (0.128, 0.272)			0.18 (0.131, 0.323)	0.154 (0.126, 0.547)			0.19 (0.097, 0.703)	0.175 (0.076, 0.757)			NA (NA, NA)	0.259 (0.127, 0.415)			0.123 (0.102, 0.434)	0.231 (0.122, 3.646)			0.139 (0.112, 0.233)	0.153 (0.126, 0.337)			0.124 (0.102, 0.166)	NA (NA, NA)			1.243 (1.243, 1.243)	NA (NA, NA)
TEfus+	TC3	count			1	1			1	1			1	1			1	1			1	1			1	1			1	1			1	1
TEfus+	TC3	time			16 (16, 16)	16 (16, 16)			16 (16, 16)	16 (16, 16)			16 (16, 16)	16 (16, 16)			16 (16, 16)	16 (16, 16)			16 (16, 16)	16 (16, 16)			16 (16, 16)	16 (16, 16)			16 (16, 16)	16 (16, 16)			16 (16, 16)	16 (16, 16)
TEfus+	TC3	n			2 (2, 2)	1 (1, 1)			3 (3, 3)	3 (3, 3)			2 (2, 2)	0 (0, 0)			0 (0, 0)	3 (3, 3)			3 (3, 3)	0 (0, 0)			4 (4, 4)	5 (5, 5)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			NA (NA, NA)	0.38 (0.38, 0.38)			0.45 (0.45, 0.45)	0.32 (0.32, 0.32)			0.48 (0.48, 0.48)	NA (NA, NA)			NA (NA, NA)	0.42 (0.42, 0.42)			0.49 (0.49, 0.49)	NA (NA, NA)			0.44 (0.44, 0.44)	0.17 (0.17, 0.17)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.153 (0.153, 0.153)	0.734 (0.734, 0.734)			0.097 (0.097, 0.097)	0.139 (0.139, 0.139)			0.046 (0.046, 0.046)	NA (NA, NA)			NA (NA, NA)	0.118 (0.118, 0.118)			0.144 (0.144, 0.144)	NA (NA, NA)			0.199 (0.199, 0.199)	0.221 (0.221, 0.221)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			3	3			3	3			3	3			3	3			3	3			3	3			3	3			3	3
TEfus+	TC4	time			30 (25, 30)	30 (25, 30)			30 (25, 30)	30 (25, 30)			30 (25, 30)	30 (25, 30)			30 (25, 30)	30 (25, 30)			30 (25, 30)	30 (25, 30)			30 (25, 30)	30 (25, 30)			30 (25, 30)	30 (25, 30)			30 (25, 30)	30 (25, 30)
TEfus+	TC4	n			3 (1, 3)	5 (1, 5)			5 (2, 5)	5 (5, 7)			3 (1, 5)	1 (0, 2)			0 (0, 0)	0 (0, 0)			1 (0, 3)	1 (0, 2)			9 (6, 10)	4 (3, 4)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.47 (0.47, 0.47)	0.41 (0.37, 0.44)			0.43 (0.38, 0.46)	0.3 (0.23, 0.39)			0.29 (0.24, 0.33)	0.36 (0.28, 0.43)			NA (NA, NA)	NA (NA, NA)			0.4 (0.38, 0.41)	0.47 (0.46, 0.48)			0.21 (0.18, 0.36)	0.27 (0.21, 0.43)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.07 (0.07, 0.07)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.12 (0.114, 0.127)	0.143 (0.139, 0.146)			0.104 (0.103, 2.258)	0.129 (0.123, 0.201)			0.138 (0.124, 0.151)	0.34 (0.251, 0.428)			NA (NA, NA)	NA (NA, NA)			0.214 (0.136, 0.293)	0.255 (0.152, 0.358)			0.15 (0.148, 0.166)	0.22 (0.146, 0.253)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	count			13	13			13	13			13	13			13	13			13	13			13	13			13	13			13	13
TEfus+	TC5	time			20 (15, 24)	20 (15, 24)			20 (15, 24)	20 (15, 24)			20 (15, 24)	20 (15, 24)			20 (15, 24)	20 (15, 24)			20 (15, 24)	20 (15, 24)			20 (15, 24)	20 (15, 24)			20 (15, 24)	20 (15, 24)			20 (15, 24)	20 (15, 24)
TEfus+	TC5	n			1 (0, 3)	3 (2, 4)			2 (0, 5)	7 (3, 9)			2 (1, 4)	1 (0, 4)			0 (0, 0)	0 (0, 1)			2 (1, 3)	0 (0, 1)			6 (3, 8)	3 (1, 6)			0 (0, 1)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	post_p			0.4 (0.36, 0.45)	0.35 (0.23, 0.45)			0.38 (0.29, 0.46)	0.36 (0.26, 0.45)			0.43 (0.23, 0.49)	0.4 (0.27, 0.46)			NA (NA, NA)	0.45 (0.41, 0.48)			0.42 (0.32, 0.49)	0.47 (0.42, 0.47)			0.35 (0.16, 0.45)	0.4 (0.28, 0.49)			0.41 (0.4, 0.42)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC5	r_prob			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0.38 (0.38, 0.38)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC5	rate			0.182 (0.079, 0.283)	0.198 (0.12, 0.254)			0.287 (0.155, 0.665)	0.182 (0.119, 0.228)			0.168 (0.101, 0.529)	0.179 (0.068, 0.741)			NA (NA, NA)	0.324 (0.019, 3.61)			0.203 (0.101, 0.364)	0.17 (0.073, 0.548)			0.173 (0.1, 0.206)	0.149 (0.098, 0.83)			0.126 (0.032, 11.878)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		23		23		23		23		23		23		23		23		23		23		23		23		23		23		23		23
PI3K+	TC1	time		23 (15, 30)		23 (15, 30)		23 (15, 30)		23 (15, 30)		23 (15, 30)		23 (15, 30)		23 (15, 30)		23 (15, 30)		23 (15, 30)		23 (15, 30)		23 (15, 30)		23 (15, 30)		23 (15, 30)		23 (15, 30)		23 (15, 30)		23 (15, 30)
PI3K+	TC1	n		8 (5, 13)		3 (1, 6)		8 (4, 12)		6 (3, 10)		0 (0, 0)		1 (0, 4)		0 (0, 2)		1 (0, 3)		0 (0, 2)		1 (0, 3)		0 (0, 0)		4 (2, 7)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.34 (0.16, 0.46)		0.35 (0.24, 0.45)		0.35 (0.18, 0.47)		0.31 (0.14, 0.47)		NA (NA, NA)		0.43 (0.38, 0.47)		0.43 (0.35, 0.49)		0.43 (0.39, 0.49)		0.41 (0.3, 0.47)		0.4 (0.3, 0.48)		NA (NA, NA)		0.4 (0.21, 0.45)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC1	r_prob		0.22 (0.22, 0.22)		0.22 (0.22, 0.22)		0.13 (0.13, 0.13)		0.09 (0.09, 0.09)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.14 (0.14, 0.14)		0.14 (0.14, 0.14)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.153 (0.113, 0.205)		0.174 (0.124, 0.32)		0.155 (0.11, 0.302)		0.184 (0.095, 0.276)		NA (NA, NA)		0.103 (0, 1.197)		0.152 (0.042, 1.689)		0.106 (0.019, 0.345)		0.229 (0.074, 0.894)		0.277 (0.105, 0.62)		NA (NA, NA)		0.157 (0.111, 0.36)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		0 (0, 0)
PI3K+	TC2	count		24		24		24		24		24		24		24		24		24		24		24		24		24		24		24		24
PI3K+	TC2	time		24 (14, 30)		24 (14, 30)		24 (14, 30)		24 (14, 30)		24 (14, 30)		24 (14, 30)		24 (14, 30)		24 (14, 30)		24 (14, 30)		24 (14, 30)		24 (14, 30)		24 (14, 30)		24 (14, 30)		24 (14, 30)		24 (14, 30)		24 (14, 30)
PI3K+	TC2	n		6 (2, 11)		3 (1, 9)		8 (4, 10)		5 (2, 7)		0 (0, 0)		1 (0, 4)		0 (0, 3)		0 (0, 2)		0 (0, 1)		1 (0, 2)		0 (0, 0)		5 (2, 7)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	post_p		0.34 (0.19, 0.47)		0.42 (0.25, 0.5)		0.38 (0.16, 0.48)		0.37 (0.18, 0.47)		NA (NA, NA)		0.44 (0.37, 0.48)		0.44 (0.4, 0.49)		0.46 (0.43, 0.49)		0.44 (0.36, 0.49)		0.45 (0.37, 0.49)		NA (NA, NA)		0.41 (0.28, 0.49)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	r_prob		0.03 (0.03, 0.03)		0.03 (0.03, 0.03)		0.07 (0.07, 0.07)		0.16 (0.16, 0.16)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.21 (0.21, 0.21)		0.21 (0.21, 0.21)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.149 (0.104, 0.341)		0.172 (0.105, 0.409)		0.147 (0.115, 0.214)		0.155 (0.121, 0.524)		NA (NA, NA)		0.121 (0.078, 0.936)		0.155 (0.048, 0.23)		0.201 (0.126, 0.471)		0.616 (0.181, 1.581)		0.184 (0, 0.652)		NA (NA, NA)		0.15 (0.106, 0.324)		0.239 (0.239, 0.239)		NA (NA, NA)		0 (0, 0)		NA (NA, NA)
PI3K+	TC3	count		9		9		9		9		9		9		9		9		9		9		9		9		9		9		9		9
PI3K+	TC3	time		18 (15, 22)		18 (15, 22)		18 (15, 22)		18 (15, 22)		18 (15, 22)		18 (15, 22)		18 (15, 22)		18 (15, 22)		18 (15, 22)		18 (15, 22)		18 (15, 22)		18 (15, 22)		18 (15, 22)		18 (15, 22)		18 (15, 22)		18 (15, 22)
PI3K+	TC3	n		8 (5, 10)		5 (2, 8)		5 (4, 8)		7 (3, 9)		0 (0, 0)		0 (0, 1)		0 (0, 1)		0 (0, 1)		0 (0, 2)		1 (0, 2)		0 (0, 0)		4 (2, 6)		0 (0, 1)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC3	post_p		0.42 (0.25, 0.45)		0.43 (0.24, 0.46)		0.36 (0.15, 0.46)		0.32 (0.19, 0.42)		NA (NA, NA)		0.43 (0.43, 0.43)		0.48 (0.48, 0.48)		0.47 (0.45, 0.49)		NA (NA, NA)		0.42 (0.39, 0.47)		NA (NA, NA)		0.36 (0.28, 0.44)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.141 (0.103, 0.22)		0.164 (0.104, 0.832)		0.165 (0.104, 0.219)		0.152 (0.119, 0.267)		NA (NA, NA)		0.186 (0.037, 0.243)		1.36 (0.382, 2.337)		0.076 (0.019, 0.193)		0.215 (0.19, 0.24)		0.269 (0.086, 0.799)		NA (NA, NA)		0.17 (0.107, 0.327)		0 (0, 0)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	count		11		11		11		11		11		11		11		11		11		11		11		11		11		11		11		11
PI3K+	TC4	time		18 (14, 28)		18 (14, 28)		18 (14, 28)		18 (14, 28)		18 (14, 28)		18 (14, 28)		18 (14, 28)		18 (14, 28)		18 (14, 28)		18 (14, 28)		18 (14, 28)		18 (14, 28)		18 (14, 28)		18 (14, 28)		18 (14, 28)		18 (14, 28)
PI3K+	TC4	n		7 (4, 10)		4 (3, 7)		7 (5, 10)		4 (1, 9)		0 (0, 0)		0 (0, 0)		0 (0, 1)		0 (0, 0)		1 (0, 2)		0 (0, 2)		0 (0, 0)		4 (2, 6)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC4	post_p		0.31 (0.09, 0.46)		0.36 (0.19, 0.44)		0.36 (0.3, 0.48)		0.43 (0.28, 0.48)		NA (NA, NA)		0.42 (0.42, 0.42)		0.48 (0.44, 0.49)		0.37 (0.37, 0.37)		0.47 (0.46, 0.49)		0.42 (0.4, 0.45)		NA (NA, NA)		0.34 (0.17, 0.42)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC4	r_prob		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0 (0, 0)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.209 (0.115, 0.321)		0.17 (0.124, 0.324)		0.168 (0.119, 0.202)		0.133 (0.1, 0.199)		NA (NA, NA)		0.143 (0.143, 0.143)		0.072 (0, 0.91)		0.479 (0.479, 0.479)		0.16 (0, 0.274)		0.216 (0.098, 0.83)		NA (NA, NA)		0.234 (0.152, 0.331)		NA (NA, NA)		0 (0, 0)		NA (NA, NA)		0.651 (0.651, 0.651)
PI3K+	TC5	count		30		30		30		30		30		30		30		30		30		30		30		30		30		30		30		30
PI3K+	TC5	time		23 (13, 33)		23 (13, 33)		23 (13, 33)		23 (13, 33)		23 (13, 33)		23 (13, 33)		23 (13, 33)		23 (13, 33)		23 (13, 33)		23 (13, 33)		23 (13, 33)		23 (13, 33)		23 (13, 33)		23 (13, 33)		23 (13, 33)		23 (13, 33)
PI3K+	TC5	n		8 (3, 14)		3 (1, 5)		7 (3, 11)		6 (3, 10)		0 (0, 0)		2 (0, 3)		1 (0, 2)		0 (0, 2)		0 (0, 1)		1 (0, 2)		0 (0, 0)		4 (2, 8)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	post_p		0.38 (0.22, 0.48)		0.41 (0.2, 0.48)		0.31 (0.14, 0.48)		0.4 (0.22, 0.45)		NA (NA, NA)		0.39 (0.29, 0.45)		0.44 (0.33, 0.47)		0.43 (0.35, 0.49)		0.44 (0.32, 0.49)		0.43 (0.36, 0.48)		NA (NA, NA)		0.42 (0.29, 0.49)		NA (NA, NA)		0.44 (0.44, 0.44)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC5	r_prob		0.38 (0.38, 0.38)		0.38 (0.38, 0.38)		0.33 (0.33, 0.33)		0.38 (0.38, 0.38)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0.29 (0.29, 0.29)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC5	rate		0.143 (0.103, 0.242)		0.212 (0.133, 0.447)		0.166 (0.113, 0.251)		0.157 (0.109, 0.226)		NA (NA, NA)		0.132 (0.077, 0.369)		0.264 (0.147, 2.309)		0.159 (0, 1.092)		0.259 (0.053, 1.416)		0.17 (0.095, 0.578)		0.4 (0.4, 0.4)		0.149 (0.106, 0.302)		0.335 (0.335, 0.335)		0.282 (0.282, 0.282)		NA (NA, NA)		0 (0, 0)