Equal randomization: TC3 and TC4 more effective in the HRD+ biomarker signature (cfr scen 5)
| signature | var | Other | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.112, shape = 1.05 |
| all | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 9.9, median = 7.1 | mean = 9.9, median = 7.1 | mean = 8.8, median = 6.3 |
| all | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.13, hr = 0.88 | af = 1.13, hr = 0.88 | af = 1, hr = 1 |
| AR- & TP53- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.096, shape = 1.05 | scale = 0.096, shape = 1.05 | scale = 0.112, shape = 1.05 |
| AR- & TP53- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 10.2, median = 7.4 | mean = 10.2, median = 7.4 | mean = 8.8, median = 6.3 |
| AR- & TP53- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.16, hr = 0.85 | af = 1.16, hr = 0.85 | af = 1, hr = 1 |
| HRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| HRD+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| HRD+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.107, shape = 1.05 | scale = 0.107, shape = 1.05 | scale = 0.112, shape = 1.05 |
| TP53+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 9.2, median = 6.6 | mean = 9.2, median = 6.6 | mean = 8.8, median = 6.3 |
| TP53+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.04, hr = 0.96 | af = 1.04, hr = 0.96 | af = 1, hr = 1 |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.097, shape = 1.05 | scale = 0.097, shape = 1.05 | scale = 0.112, shape = 1.05 |
| TEfus+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 10.1, median = 7.3 | mean = 10.1, median = 7.3 | mean = 8.8, median = 6.3 |
| TEfus+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.15, hr = 0.87 | af = 1.15, hr = 0.87 | af = 1, hr = 1 |
| PI3K+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.104, shape = 1.05 | scale = 0.104, shape = 1.05 | scale = 0.112, shape = 1.05 |
| PI3K+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 9.4, median = 6.8 | mean = 9.4, median = 6.8 | mean = 8.8, median = 6.3 |
| PI3K+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.07, hr = 0.93 | af = 1.07, hr = 0.93 | af = 1, hr = 1 |
| subtype | var | Other | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| —– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| —– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| —– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| —-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| —-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| —-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| —+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| —+- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| —+- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| —++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| —++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| —++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| –+– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| –+– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| –+-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| –+-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| –++- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| –++- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| –+++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| –+++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+— | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+— | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -+— | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| -+–+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+–+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -+–+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| -+-+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+-+- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -+-+- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| -+-++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+-++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -+-++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| -++– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -++– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -++– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| -++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -++-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -++-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| -+++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -+++- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -+++- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| -++++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| -++++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| -++++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| +—- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +—- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +—- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +—+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +—+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +—+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +–+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +–+- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +–+- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +–++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +–++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +–++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +-+– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +-+– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +-+-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +-+-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +-++- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +-++- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-+++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +-+++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 |
| +-+++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++— | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++— | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| ++— | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| ++–+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++–+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| ++–+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| ++-+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++-+- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| ++-+- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| ++-++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++-++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| ++-++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| +++– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +++– | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| +++– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| +++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +++-+ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| +++-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| ++++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| ++++- | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| ++++- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
| +++++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.036, shape = 1.05 | scale = 0.112, shape = 1.05 |
| +++++ | summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 27.4, median = 19.7 | mean = 27.4, median = 19.7 | mean = 8.8, median = 6.3 |
| +++++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.12, hr = 0.3 | af = 3.12, hr = 0.3 | af = 1, hr = 1 |
|
|
|
|
|
|
| char | overall | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|
| err_sign | 0.344 | 0.052 | 0.03 | 0.136 | 0.140 | 0.032 |
| err_type | 0.374 | 0.052 | 0.03 | 0.168 | 0.154 | 0.032 |
| pow_sign | 0.678 | 0.000 | 0.00 | 0.440 | 0.438 | 0.000 |
| pow_type | 0.788 | 0.000 | 0.00 | 0.576 | 0.578 | 0.000 |
| signature | var | Control | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| all | graduation | 0 | 4 | 2 | 4 | 7 | 3 |
| all | futility | 0 | 0 | 3 | 0 | 0 | 5 |
| all | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| all | n | 382 (357, 403) | 163 (113, 191) | 162 (108, 193) | 163 (117, 192) | 164 (115, 193) | 163 (109, 195) |
| all | n_unique | 349 (327, 368) | 150 (103, 176) | 148 (98, 179) | 150 (108, 177) | 150 (105, 177) | 149 (100, 179) |
| all | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) |
| all | time_stop | NA (NA, NA) | 6 (5, 8) | 7 (6, 13) | 6 (5, 7) | 7 (5, 10) | 8 (5, 14) |
| all | post_p | NA (NA, NA) | 0.51 (0.12, 0.88) | 0.44 (0.08, 0.83) | 0.97 (0.74, 1) | 0.97 (0.73, 1) | 0.49 (0.09, 0.89) |
| all | rate | 0.112 (0.105, 0.12) | 0.112 (0.1, 0.125) | 0.113 (0.103, 0.128) | 0.091 (0.08, 0.103) | 0.091 (0.081, 0.104) | 0.112 (0.101, 0.125) |
| AR- & TP53- | graduation | 0 | 13 | 8 | 65 | 62 | 10 |
| AR- & TP53- | futility | 0 | 77 | 94 | 4 | 10 | 79 |
| AR- & TP53- | max_n | 0 | 8 | 7 | 6 | 5 | 7 |
| AR- & TP53- | n | 212 (195, 232) | 92 (40, 113) | 92 (33, 116) | 93 (43, 116) | 93 (39, 114) | 92 (39, 118) |
| AR- & TP53- | n_unique | 195 (179, 214) | 85 (37, 106) | 85 (30, 108) | 86 (40, 108) | 86 (36, 106) | 86 (36, 111) |
| AR- & TP53- | time_trial | 36 (36, 36) | 36 (15, 36) | 36 (15, 36) | 36 (19, 36) | 36 (18, 36) | 36 (17, 36) |
| AR- & TP53- | time_stop | NA (NA, NA) | 14 (9, 31) | 15 (9, 30) | 13 (10, 25) | 13 (9, 25) | 15 (10, 33) |
| AR- & TP53- | post_p | NA (NA, NA) | 0.48 (0.09, 0.91) | 0.41 (0.09, 0.84) | 0.95 (0.69, 1) | 0.96 (0.65, 1) | 0.47 (0.09, 0.86) |
| AR- & TP53- | rate | 0.113 (0.102, 0.123) | 0.112 (0.095, 0.134) | 0.115 (0.1, 0.138) | 0.087 (0.072, 0.103) | 0.087 (0.073, 0.105) | 0.113 (0.097, 0.134) |
| HRD+ | graduation | 0 | 1 | 0 | 220 | 219 | 0 |
| HRD+ | futility | 0 | 61 | 67 | 0 | 0 | 74 |
| HRD+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| HRD+ | n | 64 (54, 75) | 28 (18, 37) | 28 (17, 39) | 25 (18, 34) | 26 (18, 34) | 28 (17, 39) |
| HRD+ | n_unique | 58 (48, 69) | 25 (15, 34) | 25 (15, 35) | 23 (16, 30) | 24 (16, 31) | 25 (15, 35) |
| HRD+ | time_trial | 36 (36, 36) | 36 (35, 36) | 36 (34, 36) | 36 (27, 36) | 36 (27, 36) | 36 (33, 36) |
| HRD+ | time_stop | NA (NA, NA) | 30 (23, 35) | 31 (24, 35) | 30 (24, 35) | 30 (24, 35) | 31 (22, 35) |
| HRD+ | post_p | NA (NA, NA) | 0.36 (0.08, 0.79) | 0.3 (0.05, 0.74) | 1 (0.99, 1) | 1 (0.99, 1) | 0.31 (0.06, 0.73) |
| HRD+ | rate | 0.112 (0.094, 0.134) | 0.112 (0.084, 0.149) | 0.117 (0.088, 0.154) | 0.035 (0.024, 0.049) | 0.036 (0.024, 0.051) | 0.117 (0.087, 0.154) |
| TP53+ | graduation | 0 | 4 | 2 | 6 | 4 | 3 |
| TP53+ | futility | 0 | 30 | 36 | 14 | 11 | 30 |
| TP53+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| TP53+ | n | 134 (121, 148) | 57 (43, 69) | 57 (43, 69) | 57 (45, 71) | 57 (44, 69) | 57 (42, 69) |
| TP53+ | n_unique | 122 (110, 135) | 51 (38, 63) | 51 (38, 63) | 52 (40, 64) | 52 (39, 63) | 52 (38, 62) |
| TP53+ | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) |
| TP53+ | time_stop | NA (NA, NA) | 20 (14, 32) | 22 (15, 32) | 23 (14, 30) | 20 (15, 31) | 20 (14, 32) |
| TP53+ | post_p | NA (NA, NA) | 0.5 (0.12, 0.89) | 0.5 (0.09, 0.85) | 0.67 (0.24, 0.96) | 0.64 (0.2, 0.94) | 0.51 (0.12, 0.88) |
| TP53+ | rate | 0.113 (0.1, 0.127) | 0.113 (0.092, 0.138) | 0.112 (0.094, 0.141) | 0.103 (0.085, 0.126) | 0.106 (0.086, 0.129) | 0.112 (0.093, 0.139) |
| TEfus+ | graduation | 0 | 2 | 0 | 6 | 3 | 0 |
| TEfus+ | futility | 0 | 8 | 18 | 1 | 3 | 13 |
| TEfus+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| TEfus+ | n | 127 (114, 143) | 54 (40, 67) | 55 (39, 67) | 54 (42, 67) | 54 (41, 66) | 54 (39, 67) |
| TEfus+ | n_unique | 116 (103, 129) | 49 (35, 61) | 50 (34, 61) | 48 (38, 60) | 49 (37, 59) | 49 (36, 61) |
| TEfus+ | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) |
| TEfus+ | time_stop | NA (NA, NA) | 22 (16, 30) | 22 (16, 33) | 18 (15, 31) | 25 (17, 30) | 20 (15, 24) |
| TEfus+ | post_p | NA (NA, NA) | 0.48 (0.11, 0.88) | 0.46 (0.1, 0.83) | 0.89 (0.49, 0.99) | 0.88 (0.46, 0.99) | 0.48 (0.12, 0.87) |
| TEfus+ | rate | 0.113 (0.099, 0.127) | 0.112 (0.092, 0.136) | 0.114 (0.096, 0.142) | 0.089 (0.073, 0.109) | 0.09 (0.072, 0.113) | 0.112 (0.093, 0.139) |
| PI3K+ | graduation | 0 | 2 | 3 | 9 | 6 | 1 |
| PI3K+ | futility | 0 | 23 | 24 | 9 | 11 | 30 |
| PI3K+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| PI3K+ | n | 129 (116, 143) | 56 (38, 70) | 55 (37, 69) | 56 (40, 70) | 56 (40, 69) | 55 (38, 70) |
| PI3K+ | n_unique | 119 (106, 131) | 50 (34, 64) | 50 (34, 62) | 50 (36, 64) | 51 (36, 63) | 50 (34, 63) |
| PI3K+ | time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) |
| PI3K+ | time_stop | NA (NA, NA) | 23 (15, 30) | 23 (14, 30) | 19 (14, 28) | 18 (14, 25) | 23 (13, 33) |
| PI3K+ | post_p | NA (NA, NA) | 0.49 (0.1, 0.87) | 0.46 (0.1, 0.85) | 0.78 (0.28, 0.98) | 0.74 (0.27, 0.97) | 0.5 (0.09, 0.86) |
| PI3K+ | rate | 0.113 (0.1, 0.127) | 0.112 (0.094, 0.137) | 0.114 (0.094, 0.139) | 0.099 (0.08, 0.122) | 0.1 (0.08, 0.124) | 0.113 (0.094, 0.139) |
| subtype | var | Control | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|---|
| —– | graduation | 0 | 17 | 10 | 69 | 67 | 12 |
| —– | futility | 0 | 77 | 96 | 4 | 10 | 81 |
| —– | max_n | 0 | 8 | 7 | 6 | 5 | 7 |
| —– | n | 117 (105, 131) | 50 (21, 63) | 49 (18, 64) | 51 (24, 66) | 51 (21, 65) | 50 (22, 66) |
| —– | n_unique | 108 (97, 122) | 48 (20, 60) | 46 (17, 61) | 48 (23, 62) | 48 (20, 61) | 48 (21, 63) |
| —– | post_p | NA (NA, NA) | 0.53 (0.12, 0.89) | 0.48 (0.1, 0.86) | 0.5 (0.13, 0.87) | 0.49 (0.12, 0.88) | 0.51 (0.13, 0.88) |
| —– | rate | 0.113 (0.099, 0.127) | 0.112 (0.089, 0.141) | 0.115 (0.094, 0.147) | 0.112 (0.092, 0.138) | 0.113 (0.091, 0.139) | 0.113 (0.092, 0.14) |
| —-+ | graduation | 0 | 19 | 13 | 75 | 71 | 13 |
| —-+ | futility | 0 | 93 | 108 | 13 | 21 | 97 |
| —-+ | max_n | 0 | 8 | 7 | 6 | 5 | 7 |
| —-+ | n | 30 (23, 38) | 13 (5, 19) | 12 (4, 19) | 13 (5, 19) | 13 (5, 19) | 13 (5, 19) |
| —-+ | n_unique | 27 (20, 35) | 12 (5, 17) | 11 (4, 17) | 12 (5, 17) | 12 (4, 18) | 12 (5, 17) |
| —-+ | post_p | NA (NA, NA) | 0.47 (0.18, 0.85) | 0.51 (0.16, 0.85) | 0.5 (0.16, 0.83) | 0.52 (0.16, 0.87) | 0.48 (0.16, 0.86) |
| —-+ | rate | 0.114 (0.089, 0.149) | 0.117 (0.075, 0.18) | 0.118 (0.077, 0.191) | 0.119 (0.079, 0.176) | 0.113 (0.072, 0.178) | 0.117 (0.074, 0.193) |
| —+- | graduation | 0 | 19 | 10 | 74 | 68 | 12 |
| —+- | futility | 0 | 83 | 104 | 5 | 12 | 89 |
| —+- | max_n | 0 | 8 | 7 | 6 | 5 | 7 |
| —+- | n | 6 (3, 10) | 2 (0, 5) | 2 (0, 5) | 3 (0, 5) | 2 (0, 5) | 2 (0, 5) |
| —+- | n_unique | 5 (2, 9) | 2 (0, 5) | 2 (0, 4) | 2 (0, 5) | 2 (0, 4) | 2 (0, 5) |
| —+- | post_p | NA (NA, NA) | 0.49 (0.27, 0.75) | 0.49 (0.28, 0.75) | 0.47 (0.26, 0.74) | 0.48 (0.28, 0.72) | 0.5 (0.28, 0.76) |
| —+- | rate | 0.117 (0.062, 0.228) | 0.12 (0.041, 0.363) | 0.126 (0.039, 0.381) | 0.132 (0.046, 0.342) | 0.129 (0.045, 0.377) | 0.118 (0.045, 0.411) |
| —++ | graduation | 0 | 21 | 13 | 79 | 72 | 13 |
| —++ | futility | 0 | 97 | 114 | 14 | 22 | 103 |
| —++ | max_n | 0 | 8 | 7 | 6 | 5 | 7 |
| —++ | n | 14 (10, 19) | 6 (2, 10) | 6 (2, 10) | 6 (2, 10) | 6 (2, 10) | 6 (2, 10) |
| —++ | n_unique | 13 (8, 18) | 5 (2, 9) | 5 (2, 9) | 5 (2, 9) | 5 (2, 9) | 5 (2, 9) |
| —++ | post_p | NA (NA, NA) | 0.48 (0.2, 0.81) | 0.47 (0.2, 0.81) | 0.53 (0.21, 0.83) | 0.53 (0.22, 0.82) | 0.46 (0.2, 0.81) |
| —++ | rate | 0.118 (0.079, 0.176) | 0.122 (0.068, 0.24) | 0.124 (0.067, 0.267) | 0.116 (0.06, 0.219) | 0.115 (0.063, 0.235) | 0.124 (0.066, 0.241) |
| –+– | graduation | 0 | 8 | 4 | 10 | 11 | 6 |
| –+– | futility | 0 | 30 | 38 | 14 | 11 | 33 |
| –+– | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| –+– | n | 28 (21, 35) | 12 (7, 16) | 11 (7, 16) | 12 (7, 17) | 12 (7, 17) | 12 (7, 17) |
| –+– | n_unique | 25 (19, 33) | 10 (6, 15) | 10 (6, 15) | 11 (7, 15) | 11 (6, 15) | 11 (6, 16) |
| –+– | post_p | NA (NA, NA) | 0.51 (0.14, 0.85) | 0.5 (0.17, 0.84) | 0.49 (0.16, 0.82) | 0.48 (0.17, 0.83) | 0.49 (0.16, 0.86) |
| –+– | rate | 0.111 (0.086, 0.147) | 0.112 (0.073, 0.182) | 0.115 (0.075, 0.177) | 0.115 (0.075, 0.174) | 0.116 (0.076, 0.178) | 0.115 (0.072, 0.177) |
| –+-+ | graduation | 0 | 10 | 7 | 18 | 16 | 7 |
| –+-+ | futility | 0 | 48 | 58 | 21 | 20 | 54 |
| –+-+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| –+-+ | n | 26 (20, 33) | 11 (7, 16) | 11 (6, 16) | 11 (7, 16) | 11 (7, 16) | 11 (6, 15) |
| –+-+ | n_unique | 24 (18, 30) | 10 (6, 15) | 10 (5, 14) | 10 (6, 15) | 10 (6, 15) | 10 (5, 14) |
| –+-+ | post_p | NA (NA, NA) | 0.51 (0.17, 0.83) | 0.5 (0.17, 0.83) | 0.53 (0.17, 0.87) | 0.48 (0.19, 0.82) | 0.49 (0.16, 0.85) |
| –+-+ | rate | 0.116 (0.083, 0.15) | 0.117 (0.075, 0.182) | 0.114 (0.078, 0.174) | 0.113 (0.071, 0.18) | 0.114 (0.077, 0.172) | 0.116 (0.07, 0.189) |
| –++- | graduation | 0 | 10 | 4 | 16 | 14 | 6 |
| –++- | futility | 0 | 36 | 50 | 14 | 14 | 39 |
| –++- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| –++- | n | 8 (5, 12) | 3 (1, 6) | 3 (1, 6) | 3 (1, 6) | 3 (1, 6) | 3 (1, 6) |
| –++- | n_unique | 7 (4, 11) | 3 (1, 6) | 3 (1, 6) | 3 (1, 6) | 3 (1, 6) | 3 (1, 6) |
| –++- | post_p | NA (NA, NA) | 0.49 (0.27, 0.78) | 0.46 (0.23, 0.75) | 0.51 (0.26, 0.77) | 0.5 (0.27, 0.79) | 0.46 (0.23, 0.75) |
| –++- | rate | 0.114 (0.068, 0.199) | 0.12 (0.051, 0.297) | 0.126 (0.057, 0.315) | 0.112 (0.055, 0.321) | 0.118 (0.048, 0.302) | 0.13 (0.047, 0.346) |
| –+++ | graduation | 0 | 12 | 7 | 22 | 18 | 7 |
| –+++ | futility | 0 | 53 | 67 | 21 | 22 | 59 |
| –+++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| –+++ | n | 20 (15, 27) | 9 (5, 13) | 8 (4, 12) | 9 (5, 14) | 9 (5, 13) | 8 (4, 13) |
| –+++ | n_unique | 19 (13, 25) | 8 (4, 12) | 7 (4, 12) | 8 (4, 12) | 8 (4, 12) | 8 (4, 12) |
| –+++ | post_p | NA (NA, NA) | 0.49 (0.19, 0.82) | 0.48 (0.14, 0.84) | 0.53 (0.2, 0.86) | 0.47 (0.19, 0.83) | 0.5 (0.18, 0.84) |
| –+++ | rate | 0.112 (0.084, 0.159) | 0.117 (0.071, 0.204) | 0.117 (0.069, 0.214) | 0.111 (0.068, 0.185) | 0.119 (0.071, 0.197) | 0.114 (0.067, 0.2) |
| -+— | graduation | 0 | 18 | 10 | 278 | 278 | 12 |
| -+— | futility | 0 | 130 | 159 | 4 | 10 | 143 |
| -+— | max_n | 0 | 7 | 7 | 5 | 5 | 7 |
| -+— | n | 26 (20, 32) | 11 (5, 17) | 11 (4, 18) | 11 (5, 16) | 11 (5, 16) | 11 (5, 18) |
| -+— | n_unique | 24 (17, 30) | 10 (4, 15) | 10 (4, 16) | 10 (5, 14) | 10 (4, 15) | 10 (4, 16) |
| -+— | post_p | NA (NA, NA) | 0.34 (0.1, 0.7) | 0.33 (0.09, 0.72) | 0.97 (0.79, 1) | 0.97 (0.77, 1) | 0.32 (0.1, 0.7) |
| -+— | rate | 0.112 (0.084, 0.15) | 0.118 (0.074, 0.19) | 0.119 (0.078, 0.195) | 0.036 (0.018, 0.06) | 0.036 (0.016, 0.06) | 0.117 (0.076, 0.191) |
| -+–+ | graduation | 0 | 20 | 13 | 281 | 281 | 12 |
| -+–+ | futility | 0 | 143 | 169 | 12 | 19 | 154 |
| -+–+ | max_n | 0 | 7 | 7 | 5 | 5 | 7 |
| -+–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+–+ | post_p | NA (NA, NA) | 0.46 (0.44, 0.47) | 0.5 (0.47, 0.53) | 0.53 (0.48, 0.54) | 0.55 (0.54, 0.56) | 0.49 (0.45, 0.54) |
| -+–+ | rate | 0.123 (0, 0.405) | 0.257 (0.098, 0.624) | 0.311 (0.047, 0.665) | 0.06 (0, 0.782) | 0.038 (0, 0.197) | 0.339 (0.036, 5.583) |
| -+-+- | graduation | 0 | 20 | 10 | 281 | 277 | 12 |
| -+-+- | futility | 0 | 134 | 166 | 5 | 12 | 149 |
| -+-+- | max_n | 0 | 7 | 7 | 5 | 5 | 7 |
| -+-+- | n | 13 (9, 18) | 5 (2, 10) | 5 (2, 10) | 5 (2, 9) | 5 (2, 9) | 6 (2, 10) |
| -+-+- | n_unique | 12 (7, 17) | 5 (1, 9) | 5 (2, 9) | 4 (2, 8) | 4 (2, 8) | 5 (1, 9) |
| -+-+- | post_p | NA (NA, NA) | 0.4 (0.17, 0.7) | 0.4 (0.16, 0.67) | 0.86 (0.57, 0.98) | 0.85 (0.56, 0.97) | 0.39 (0.19, 0.67) |
| -+-+- | rate | 0.12 (0.078, 0.174) | 0.117 (0.062, 0.237) | 0.121 (0.061, 0.282) | 0.035 (0.011, 0.08) | 0.036 (0.014, 0.087) | 0.122 (0.061, 0.235) |
| -+-++ | graduation | 0 | 22 | 13 | 283 | 280 | 12 |
| -+-++ | futility | 0 | 146 | 174 | 13 | 20 | 159 |
| -+-++ | max_n | 0 | 7 | 7 | 5 | 5 | 7 |
| -+-++ | n | 6 (3, 9) | 2 (0, 5) | 2 (0, 5) | 2 (0, 5) | 2 (0, 5) | 2 (0, 5) |
| -+-++ | n_unique | 5 (2, 8) | 2 (0, 4) | 2 (0, 5) | 2 (0, 4) | 2 (0, 4) | 2 (0, 4) |
| -+-++ | post_p | NA (NA, NA) | 0.44 (0.27, 0.66) | 0.44 (0.27, 0.63) | 0.67 (0.47, 0.87) | 0.67 (0.44, 0.87) | 0.44 (0.27, 0.64) |
| -+-++ | rate | 0.113 (0.056, 0.217) | 0.119 (0.04, 0.35) | 0.123 (0.049, 0.407) | 0.034 (0, 0.121) | 0.033 (0, 0.138) | 0.12 (0.042, 0.419) |
| -++– | graduation | 0 | 8 | 3 | 227 | 230 | 5 |
| -++– | futility | 0 | 86 | 99 | 12 | 9 | 102 |
| -++– | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| -++– | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -++– | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -++– | post_p | NA (NA, NA) | 0.47 (0.47, 0.48) | 0.49 (0.47, 0.52) | 0.5 (0.5, 0.5) | NA (NA, NA) | 0.43 (0.43, 0.43) |
| -++– | rate | 0.088 (0, 0.609) | 0.219 (0, 0.976) | 0.134 (0, 1.078) | 0 (0, 0.376) | 0.072 (0, 0.107) | 0.198 (0, 0.614) |
| -++-+ | graduation | 0 | 10 | 6 | 232 | 234 | 5 |
| -++-+ | futility | 0 | 101 | 116 | 18 | 16 | 119 |
| -++-+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| -++-+ | n | 3 (1, 6) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) |
| -++-+ | n_unique | 3 (1, 6) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) |
| -++-+ | post_p | NA (NA, NA) | 0.45 (0.3, 0.62) | 0.44 (0.32, 0.63) | 0.61 (0.43, 0.8) | 0.6 (0.43, 0.81) | 0.45 (0.31, 0.61) |
| -++-+ | rate | 0.115 (0.044, 0.307) | 0.133 (0, 0.565) | 0.14 (0.034, 0.528) | 0.035 (0, 0.179) | 0.032 (0, 0.209) | 0.136 (0.027, 0.581) |
| -+++- | graduation | 0 | 10 | 3 | 231 | 231 | 5 |
| -+++- | futility | 0 | 89 | 111 | 12 | 12 | 106 |
| -+++- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| -+++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| -+++- | post_p | NA (NA, NA) | 0.57 (0.53, 0.6) | 0.41 (0.4, 0.53) | NA (NA, NA) | 0.62 (0.56, 0.67) | 0.48 (0.48, 0.48) |
| -+++- | rate | 0.104 (0, 0.823) | 0.122 (0, 0.696) | 0.125 (0.021, 0.385) | 0.076 (0, 0.291) | 0 (0, 0.145) | 0.141 (0, 0.539) |
| -++++ | graduation | 0 | 12 | 6 | 234 | 234 | 5 |
| -++++ | futility | 0 | 104 | 125 | 18 | 18 | 122 |
| -++++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| -++++ | n | 3 (1, 6) | 1 (0, 3) | 2 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 4) |
| -++++ | n_unique | 3 (1, 6) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) |
| -++++ | post_p | NA (NA, NA) | 0.45 (0.34, 0.64) | 0.44 (0.31, 0.63) | 0.62 (0.44, 0.81) | 0.61 (0.44, 0.81) | 0.46 (0.3, 0.64) |
| -++++ | rate | 0.12 (0.052, 0.321) | 0.126 (0, 0.433) | 0.133 (0.028, 0.461) | 0.028 (0, 0.135) | 0.032 (0, 0.148) | 0.129 (0, 0.506) |
| +—- | graduation | 0 | 4 | 2 | 4 | 7 | 3 |
| +—- | futility | 0 | 0 | 3 | 0 | 0 | 5 |
| +—- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +—- | n | 6 (3, 10) | 2 (1, 5) | 2 (0, 5) | 2 (1, 5) | 2 (1, 5) | 2 (1, 5) |
| +—- | n_unique | 5 (3, 9) | 2 (0, 4) | 2 (0, 4) | 2 (1, 5) | 2 (0, 4) | 2 (0, 4) |
| +—- | post_p | NA (NA, NA) | 0.49 (0.28, 0.71) | 0.48 (0.3, 0.72) | 0.5 (0.29, 0.74) | 0.47 (0.27, 0.7) | 0.48 (0.27, 0.71) |
| +—- | rate | 0.111 (0.062, 0.217) | 0.123 (0.052, 0.365) | 0.125 (0.045, 0.331) | 0.116 (0.03, 0.389) | 0.127 (0.046, 0.363) | 0.122 (0.042, 0.363) |
| +—+ | graduation | 0 | 6 | 5 | 13 | 13 | 4 |
| +—+ | futility | 0 | 23 | 27 | 9 | 11 | 34 |
| +—+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +—+ | n | 3 (1, 5) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) | 1 (0, 3) |
| +—+ | n_unique | 2 (1, 5) | 1 (0, 3) | 1 (0, 3) | 1 (0, 2) | 1 (0, 3) | 1 (0, 2) |
| +—+ | post_p | NA (NA, NA) | 0.47 (0.32, 0.66) | 0.49 (0.36, 0.67) | 0.48 (0.35, 0.66) | 0.48 (0.37, 0.69) | 0.48 (0.35, 0.7) |
| +—+ | rate | 0.121 (0.036, 0.346) | 0.139 (0, 0.6) | 0.123 (0, 0.658) | 0.145 (0, 0.666) | 0.131 (0, 0.659) | 0.126 (0, 0.634) |
| +–+- | graduation | 0 | 6 | 2 | 10 | 10 | 3 |
| +–+- | futility | 0 | 8 | 20 | 1 | 3 | 18 |
| +–+- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +–+- | n | 9 (5, 13) | 4 (2, 6) | 4 (1, 6) | 4 (1, 7) | 4 (2, 7) | 4 (1, 7) |
| +–+- | n_unique | 8 (5, 12) | 3 (1, 6) | 3 (1, 6) | 3 (1, 6) | 4 (1, 6) | 3 (1, 6) |
| +–+- | post_p | NA (NA, NA) | 0.5 (0.25, 0.75) | 0.49 (0.28, 0.75) | 0.48 (0.25, 0.78) | 0.51 (0.25, 0.78) | 0.49 (0.23, 0.77) |
| +–+- | rate | 0.119 (0.069, 0.193) | 0.119 (0.05, 0.262) | 0.12 (0.054, 0.259) | 0.122 (0.047, 0.264) | 0.115 (0.051, 0.282) | 0.119 (0.05, 0.294) |
| +–++ | graduation | 0 | 8 | 5 | 17 | 15 | 4 |
| +–++ | futility | 0 | 29 | 39 | 10 | 13 | 43 |
| +–++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +–++ | n | 4 (2, 8) | 2 (0, 4) | 2 (0, 4) | 2 (0, 4) | 2 (0, 4) | 2 (0, 4) |
| +–++ | n_unique | 4 (2, 7) | 2 (0, 4) | 2 (0, 4) | 1 (0, 4) | 2 (0, 4) | 2 (0, 3) |
| +–++ | post_p | NA (NA, NA) | 0.49 (0.31, 0.73) | 0.48 (0.31, 0.7) | 0.49 (0.31, 0.73) | 0.48 (0.31, 0.71) | 0.5 (0.32, 0.71) |
| +–++ | rate | 0.12 (0.056, 0.259) | 0.125 (0.037, 0.397) | 0.124 (0.04, 0.46) | 0.125 (0.028, 0.437) | 0.126 (0.029, 0.416) | 0.118 (0.009, 0.456) |
| +-+– | graduation | 0 | 8 | 4 | 10 | 11 | 6 |
| +-+– | futility | 0 | 30 | 38 | 14 | 11 | 33 |
| +-+– | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +-+– | n | 2 (0, 4) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) |
| +-+– | n_unique | 2 (0, 4) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) |
| +-+– | post_p | NA (NA, NA) | 0.49 (0.37, 0.61) | 0.48 (0.38, 0.66) | 0.49 (0.38, 0.64) | 0.51 (0.37, 0.65) | 0.48 (0.39, 0.62) |
| +-+– | rate | 0.13 (0.032, 0.428) | 0.12 (0, 0.64) | 0.136 (0, 0.8) | 0.122 (0, 0.716) | 0.123 (0, 0.781) | 0.138 (0, 0.743) |
| +-+-+ | graduation | 0 | 10 | 7 | 18 | 16 | 7 |
| +-+-+ | futility | 0 | 48 | 58 | 21 | 20 | 54 |
| +-+-+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +-+-+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +-+-+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +-+-+ | post_p | NA (NA, NA) | 0.46 (0.46, 0.46) | 0.55 (0.54, 0.55) | 0.5 (0.45, 0.51) | 0.57 (0.57, 0.57) | 0.48 (0.46, 0.58) |
| +-+-+ | rate | 0.199 (0, 0.85) | 0.197 (0, 1.492) | 0.125 (0, 1.01) | 0.099 (0, 0.475) | 0.142 (0, 0.915) | 0.121 (0, 0.457) |
| +-++- | graduation | 0 | 10 | 4 | 16 | 14 | 6 |
| +-++- | futility | 0 | 36 | 50 | 14 | 14 | 39 |
| +-++- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +-++- | n | 22 (17, 29) | 9 (5, 14) | 9 (5, 14) | 9 (5, 14) | 10 (5, 14) | 9 (5, 14) |
| +-++- | n_unique | 20 (15, 26) | 9 (4, 13) | 8 (5, 13) | 8 (4, 13) | 8 (4, 13) | 8 (4, 13) |
| +-++- | post_p | NA (NA, NA) | 0.5 (0.18, 0.85) | 0.48 (0.15, 0.8) | 0.51 (0.18, 0.81) | 0.5 (0.18, 0.84) | 0.51 (0.17, 0.84) |
| +-++- | rate | 0.113 (0.086, 0.151) | 0.113 (0.073, 0.195) | 0.119 (0.07, 0.205) | 0.114 (0.074, 0.191) | 0.115 (0.068, 0.194) | 0.115 (0.07, 0.192) |
| +-+++ | graduation | 0 | 12 | 7 | 22 | 18 | 7 |
| +-+++ | futility | 0 | 53 | 67 | 21 | 22 | 59 |
| +-+++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +-+++ | n | 17 (12, 23) | 7 (3, 11) | 7 (3, 12) | 7 (4, 11) | 7 (4, 11) | 7 (3, 11) |
| +-+++ | n_unique | 16 (11, 21) | 7 (3, 10) | 7 (3, 11) | 7 (3, 10) | 7 (3, 10) | 7 (3, 10) |
| +-+++ | post_p | NA (NA, NA) | 0.49 (0.2, 0.83) | 0.48 (0.19, 0.81) | 0.48 (0.19, 0.82) | 0.47 (0.18, 0.81) | 0.51 (0.2, 0.84) |
| +-+++ | rate | 0.112 (0.078, 0.155) | 0.116 (0.066, 0.204) | 0.116 (0.065, 0.224) | 0.12 (0.066, 0.203) | 0.12 (0.066, 0.213) | 0.111 (0.06, 0.223) |
| ++— | graduation | 0 | 5 | 2 | 224 | 226 | 3 |
| ++— | futility | 0 | 61 | 70 | 0 | 0 | 79 |
| ++— | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++— | n | 9 (6, 14) | 4 (2, 7) | 4 (2, 7) | 4 (1, 7) | 4 (1, 7) | 4 (2, 7) |
| ++— | n_unique | 9 (5, 13) | 4 (1, 6) | 4 (1, 6) | 3 (1, 6) | 3 (1, 6) | 3 (1, 7) |
| ++— | post_p | NA (NA, NA) | 0.41 (0.18, 0.66) | 0.4 (0.17, 0.65) | 0.77 (0.51, 0.94) | 0.77 (0.5, 0.93) | 0.4 (0.18, 0.67) |
| ++— | rate | 0.11 (0.07, 0.183) | 0.121 (0.053, 0.261) | 0.12 (0.055, 0.301) | 0.033 (0, 0.095) | 0.036 (0, 0.096) | 0.119 (0.055, 0.294) |
| ++–+ | graduation | 0 | 7 | 5 | 229 | 231 | 3 |
| ++–+ | futility | 0 | 81 | 91 | 8 | 9 | 101 |
| ++–+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++–+ | post_p | NA (NA, NA) | NA (NA, NA) | 0.5 (0.49, 0.52) | 0.52 (0.5, 0.54) | 0.53 (0.47, 0.66) | 0.42 (0.42, 0.42) |
| ++–+ | rate | 0.12 (0, 0.71) | 0.166 (0, 0.273) | 0.128 (0, 0.337) | 0 (0, 0.238) | 0 (0, 0.182) | 0.22 (0, 1.846) |
| ++-+- | graduation | 0 | 7 | 2 | 228 | 227 | 3 |
| ++-+- | futility | 0 | 66 | 86 | 1 | 3 | 89 |
| ++-+- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++-+- | n | 1 (0, 3) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 1) |
| ++-+- | n_unique | 1 (0, 3) | 0 (0, 2) | 0 (0, 2) | 0 (0, 1) | 0 (0, 2) | 0 (0, 1) |
| ++-+- | post_p | NA (NA, NA) | 0.47 (0.4, 0.61) | 0.46 (0.37, 0.6) | 0.56 (0.42, 0.63) | 0.56 (0.44, 0.65) | 0.49 (0.39, 0.59) |
| ++-+- | rate | 0.144 (0, 0.418) | 0.125 (0, 0.551) | 0.147 (0, 0.626) | 0.032 (0, 0.222) | 0.032 (0, 0.201) | 0.118 (0, 0.894) |
| ++-++ | graduation | 0 | 9 | 5 | 231 | 231 | 3 |
| ++-++ | futility | 0 | 85 | 102 | 9 | 11 | 108 |
| ++-++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++-++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++-++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++-++ | post_p | NA (NA, NA) | 0.49 (0.48, 0.5) | 0.44 (0.44, 0.44) | NA (NA, NA) | 0.46 (0.44, 0.54) | 0.49 (0.45, 0.51) |
| ++-++ | rate | 0.088 (0, 0.84) | 0.11 (0, 0.973) | 0.1 (0, 0.324) | 0 (0, 0.197) | 0 (0, 0.719) | 0.124 (0, 0.269) |
| +++– | graduation | 0 | 8 | 3 | 227 | 230 | 5 |
| +++– | futility | 0 | 86 | 99 | 12 | 9 | 102 |
| +++– | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +++– | n | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) |
| +++– | n_unique | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) |
| +++– | post_p | NA (NA, NA) | 0.46 (0.39, 0.52) | 0.48 (0.44, 0.55) | 0.56 (0.46, 0.61) | 0.54 (0.46, 0.6) | 0.5 (0.44, 0.57) |
| +++– | rate | 0.135 (0, 0.549) | 0.136 (0, 0.974) | 0.153 (0, 1.018) | 0 (0, 0.246) | 0.068 (0, 0.805) | 0.185 (0, 0.574) |
| +++-+ | graduation | 0 | 10 | 6 | 232 | 234 | 5 |
| +++-+ | futility | 0 | 101 | 116 | 18 | 16 | 119 |
| +++-+ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +++-+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++-+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++-+ | post_p | NA (NA, NA) | 0.54 (0.52, 0.58) | 0.57 (0.49, 0.58) | 0.54 (0.51, 0.58) | 0.48 (0.44, 0.52) | NA (NA, NA) |
| +++-+ | rate | 0.129 (0, 0.838) | 0.11 (0, 0.479) | 0.148 (0, 0.746) | 0 (0, 0.139) | 0.067 (0, 0.467) | 0.026 (0, 0.421) |
| ++++- | graduation | 0 | 10 | 3 | 231 | 231 | 5 |
| ++++- | futility | 0 | 89 | 111 | 12 | 12 | 106 |
| ++++- | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| ++++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++- | post_p | NA (NA, NA) | NA (NA, NA) | 0.51 (0.49, 0.51) | 0.52 (0.51, 0.54) | NA (NA, NA) | NA (NA, NA) |
| ++++- | rate | 0.127 (0, 0.81) | 0.104 (0, 0.302) | 0.089 (0, 0.386) | 0.044 (0, 0.399) | 0.075 (0, 0.23) | 0.092 (0, 0.561) |
| +++++ | graduation | 0 | 12 | 6 | 234 | 234 | 5 |
| +++++ | futility | 0 | 104 | 125 | 18 | 18 | 122 |
| +++++ | max_n | 0 | 0 | 0 | 0 | 0 | 0 |
| +++++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++++ | post_p | NA (NA, NA) | 0.48 (0.48, 0.48) | 0.51 (0.5, 0.54) | 0.5 (0.46, 0.53) | 0.5 (0.47, 0.52) | 0.49 (0.47, 0.51) |
| +++++ | rate | 0.148 (0, 0.413) | 0.177 (0.015, 1.408) | 0.117 (0, 0.402) | 0 (0, 0.229) | 0 (0, 0.299) | 0.091 (0, 0.891) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|
| all | count | 4 | 2 | 4 | 7 | 3 |
| all | time_stop | 6 (5, 8) | 7 (7, 7) | 6 (5, 7) | 7 (5, 10) | 5 (5, 9) |
| all | n_trt | 28 (26, 33) | 26 (26, 27) | 32 (27, 38) | 34 (28, 48) | 27 (25, 43) |
| all | n_control | 48 (39, 70) | 64 (61, 67) | 64 (49, 68) | 69 (36, 90) | 40 (33, 83) |
| all | post_p | 0.89 (0.87, 0.96) | 0.95 (0.92, 0.97) | 0.98 (0.96, 0.99) | 0.98 (0.95, 1) | 0.9 (0.89, 0.98) |
| all | order | 1 (1, 1) | 1.5 (1.1, 1.9) | 1 (1, 1) | 1 (1, 2) | 1 (1, 1) |
| AR- & TP53- | count | 13 | 8 | 65 | 62 | 10 |
| AR- & TP53- | time_stop | 11 (9, 13) | 12 (10, 18) | 14 (10, 26) | 14 (9, 27) | 14 (11, 17) |
| AR- & TP53- | n_trt | 28 (25, 39) | 30 (26, 44) | 33 (26, 77) | 35 (26, 69) | 34 (27, 37) |
| AR- & TP53- | n_control | 60 (47, 78) | 71 (50, 103) | 73 (51, 158) | 78 (48, 146) | 72 (42, 89) |
| AR- & TP53- | post_p | 0.92 (0.88, 0.99) | 0.94 (0.88, 0.98) | 0.98 (0.92, 1) | 0.97 (0.88, 1) | 0.93 (0.87, 0.99) |
| AR- & TP53- | order | 1 (1, 1) | 1 (1, 2) | 1 (1, 2) | 1 (1, 2) | 1 (1, 1.2) |
| HRD+ | count | 1 | 220 | 219 | ||
| HRD+ | time_stop | 36 (36, 36) | 30 (24, 35) | 30 (24, 35) | ||
| HRD+ | n_trt | 25 (25, 25) | 26 (25, 30) | 26 (25, 31) | ||
| HRD+ | n_control | 63 (63, 63) | 54 (40, 68) | 53 (41, 68) | ||
| HRD+ | post_p | 1 (1, 1) | 1 (0.99, 1) | 1 (0.99, 1) | ||
| HRD+ | order | 2 (2, 2) | 2 (1, 2) | 1 (1, 2) | ||
| TP53+ | count | 4 | 2 | 6 | 4 | 3 |
| TP53+ | time_stop | 18 (16, 22) | 24 (22, 26) | 21 (16, 24) | 22 (17, 31) | 18 (16, 24) |
| TP53+ | n_trt | 28 (26, 34) | 27 (25, 29) | 30 (27, 34) | 34 (25, 47) | 26 (26, 38) |
| TP53+ | n_control | 64 (53, 82) | 94 (89, 98) | 73 (56, 96) | 80 (64, 106) | 65 (58, 83) |
| TP53+ | post_p | 0.96 (0.89, 0.99) | 0.97 (0.96, 0.99) | 0.97 (0.89, 0.99) | 1 (0.99, 1) | 0.99 (0.95, 0.99) |
| TP53+ | order | 1 (1, 1) | 1.5 (1.1, 1.9) | 1 (1, 2) | 1.5 (1, 2.7) | 2 (1.2, 2) |
| TEfus+ | count | 2 | 6 | 3 | ||
| TEfus+ | time_stop | 20 (20, 21) | 22 (15, 32) | 19 (16, 25) | ||
| TEfus+ | n_trt | 29 (27, 31) | 32 (25, 50) | 27 (25, 31) | ||
| TEfus+ | n_control | 84 (77, 91) | 78 (52, 112) | 84 (58, 88) | ||
| TEfus+ | post_p | 0.99 (0.98, 0.99) | 0.99 (0.98, 1) | 1 (0.89, 1) | ||
| TEfus+ | order | 1 (1, 1) | 1 (1, 1.5) | 2 (1.2, 2.8) | ||
| PI3K+ | count | 2 | 3 | 9 | 6 | 1 |
| PI3K+ | time_stop | 20 (18, 22) | 20 (16, 24) | 22 (13, 28) | 18 (16, 22) | 23 (23, 23) |
| PI3K+ | n_trt | 31 (29, 33) | 32 (26, 34) | 30 (26, 35) | 29 (25, 30) | 32 (32, 32) |
| PI3K+ | n_control | 75 (70, 80) | 68 (63, 82) | 81 (44, 95) | 58 (49, 72) | 71 (71, 71) |
| PI3K+ | post_p | 0.96 (0.93, 0.99) | 0.97 (0.89, 0.99) | 0.99 (0.98, 1) | 0.97 (0.93, 0.99) | 0.97 (0.97, 0.97) |
| PI3K+ | order | 1.5 (1.1, 1.9) | 2 (1.2, 2) | 2 (1, 3.2) | 1 (1, 2) | 1 (1, 1) |
| signature | var | TC1 | TC2 | TC3 | TC4 | TC5 |
|---|---|---|---|---|---|---|
| all | count | 3 | 5 | |||
| all | time_stop | 8 (6, 14) | 10 (6, 14) | |||
| all | n_trt | 39 (31, 61) | 48 (29, 64) | |||
| all | n_control | 85 (43, 166) | 109 (42, 137) | |||
| all | post_p | 0.04 (0.02, 0.08) | 0.05 (0, 0.17) | |||
| all | order | 1 (1, 1.8) | 1 (1, 2.2) | |||
| AR- & TP53- | count | 77 | 94 | 4 | 10 | 79 |
| AR- & TP53- | time_stop | 15 (9, 32) | 15 (9, 30) | 11 (10, 11) | 12 (9, 16) | 15 (10, 33) |
| AR- & TP53- | n_trt | 41 (26, 83) | 34 (26, 81) | 27 (26, 33) | 28 (25, 44) | 39 (27, 86) |
| AR- & TP53- | n_control | 86 (46, 184) | 86 (47, 174) | 58 (55, 60) | 61 (39, 87) | 83 (52, 197) |
| AR- & TP53- | post_p | 0.14 (0.04, 0.23) | 0.11 (0.02, 0.23) | 0.11 (0.03, 0.19) | 0.16 (0.05, 0.26) | 0.1 (0.04, 0.26) |
| AR- & TP53- | order | 1 (1, 3) | 1 (1, 3) | 1 (1, 1.7) | 1 (1, 1.1) | 1 (1, 2.2) |
| HRD+ | count | 61 | 67 | 74 | ||
| HRD+ | time_stop | 30 (23, 35) | 31 (24, 35) | 31 (22, 35) | ||
| HRD+ | n_trt | 26 (25, 34) | 26 (25, 33) | 26 (25, 33) | ||
| HRD+ | n_control | 52 (36, 64) | 57 (44, 69) | 54 (39, 65) | ||
| HRD+ | post_p | 0.12 (0.02, 0.24) | 0.09 (0.02, 0.22) | 0.13 (0.03, 0.25) | ||
| HRD+ | order | 2 (1, 4) | 2 (1, 4) | 2 (1, 3) | ||
| TP53+ | count | 30 | 36 | 14 | 11 | 30 |
| TP53+ | time_stop | 22 (14, 32) | 22 (14, 32) | 24 (13, 33) | 20 (14, 29) | 20 (14, 32) |
| TP53+ | n_trt | 32 (26, 51) | 34 (26, 52) | 32 (25, 48) | 36 (25, 43) | 30 (25, 47) |
| TP53+ | n_control | 82 (46, 122) | 80 (56, 123) | 84 (46, 129) | 75 (46, 110) | 73 (50, 125) |
| TP53+ | post_p | 0.05 (0.02, 0.13) | 0.03 (0, 0.16) | 0.06 (0.01, 0.17) | 0.1 (0.02, 0.2) | 0.06 (0.02, 0.18) |
| TP53+ | order | 1 (1, 3) | 1 (1, 2.5) | 1 (1, 2.7) | 1 (1, 2) | 1.5 (1, 4) |
| TEfus+ | count | 8 | 18 | 1 | 3 | 13 |
| TEfus+ | time_stop | 23 (16, 31) | 22 (16, 33) | 16 (16, 16) | 30 (25, 30) | 20 (15, 24) |
| TEfus+ | n_trt | 35 (28, 39) | 32 (26, 42) | 26 (26, 26) | 33 (31, 35) | 27 (25, 37) |
| TEfus+ | n_control | 76 (58, 107) | 71 (53, 127) | 62 (62, 62) | 108 (94, 121) | 67 (50, 90) |
| TEfus+ | post_p | 0.03 (0.02, 0.14) | 0.05 (0, 0.17) | 0.18 (0.18, 0.18) | 0.06 (0.02, 0.11) | 0.06 (0.01, 0.16) |
| TEfus+ | order | 1.5 (1, 3.3) | 2 (1, 4) | 1 (1, 1) | 3 (1.4, 3.8) | 2 (1, 3.8) |
| PI3K+ | count | 23 | 24 | 9 | 11 | 30 |
| PI3K+ | time_stop | 23 (15, 30) | 24 (14, 30) | 18 (15, 22) | 18 (14, 28) | 23 (13, 33) |
| PI3K+ | n_trt | 33 (25, 47) | 28 (25, 45) | 31 (25, 37) | 27 (26, 33) | 30 (26, 44) |
| PI3K+ | n_control | 82 (52, 110) | 80 (46, 104) | 61 (49, 77) | 63 (44, 104) | 86 (46, 118) |
| PI3K+ | post_p | 0.07 (0.01, 0.23) | 0.08 (0.01, 0.22) | 0.16 (0.02, 0.26) | 0.1 (0.04, 0.19) | 0.06 (0.02, 0.16) |
| PI3K+ | order | 2 (1, 3) | 2 (1, 4) | 2 (1, 2.2) | 1 (1, 2) | 2 (1, 4) |
| signature | treatment | var | —– | —-+ | —+- | —++ | –+– | –+-+ | –++- | –+++ | -+— | -+–+ | -+-+- | -+-++ | -++– | -++-+ | -+++- | -++++ | +—- | +—+ | +–+- | +–++ | +-+– | +-+-+ | +-++- | +-+++ | ++— | ++–+ | ++-+- | ++-++ | +++– | +++-+ | ++++- | +++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | TC1 | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| all | TC1 | time | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) |
| all | TC1 | n | 8 (7, 14) | 2 (1, 3) | 0 (0, 1) | 2 (1, 4) | 2 (0, 5) | 4 (1, 5) | 0 (0, 2) | 1 (1, 2) | 2 (0, 4) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 2 (1, 2) | 2 (0, 2) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | post_p | 0.68 (0.6, 0.78) | 0.57 (0.56, 0.58) | 0.53 (0.53, 0.53) | 0.55 (0.54, 0.57) | 0.59 (0.55, 0.59) | 0.55 (0.52, 0.58) | 0.52 (0.52, 0.52) | 0.55 (0.51, 0.6) | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.59 (0.55, 0.64) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.55 (0.53, 0.57) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.54 (0.51, 0.55) | 0.53 (0.52, 0.59) | 0.52 (0.51, 0.52) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC1 | r_prob | 0.41 (0.41, 0.41) | 0.22 (0.22, 0.22) | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0.31 (0.31, 0.31) | 0.13 (0.13, 0.13) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | rate | 0.049 (0.041, 0.072) | 0.147 (0.029, 0.219) | 0 (0, 0) | 0.042 (0, 1.465) | 0 (0, 0.034) | 0 (0, 0.063) | 0 (0, 0) | 0 (0, 13.89) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0.375 (0.375, 0.375) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0.104) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| all | TC2 | time | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) |
| all | TC2 | n | 7 (6, 8) | 2 (1, 4) | 1 (1, 1) | 3 (3, 3) | 1 (0, 2) | 1 (1, 1) | 0 (0, 1) | 1 (1, 1) | 2 (1, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 2 (2, 2) | 0 (0, 1) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 3 (3, 3) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | post_p | 0.63 (0.59, 0.66) | 0.64 (0.59, 0.69) | 0.52 (0.52, 0.52) | 0.53 (0.53, 0.53) | 0.56 (0.56, 0.56) | 0.54 (0.53, 0.54) | 0.56 (0.56, 0.56) | 0.56 (0.54, 0.58) | 0.53 (0.52, 0.54) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.5 (0.5, 0.5) | 0.53 (0.53, 0.53) | NA (NA, NA) | 0.54 (0.54, 0.54) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.59 (0.57, 0.61) | 0.57 (0.57, 0.57) | 0.54 (0.54, 0.54) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | r_prob | 0.18 (0.18, 0.18) | 0.03 (0.03, 0.03) | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0.17 (0.17, 0.17) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | rate | 0.064 (0.048, 0.08) | 0.03 (0.006, 0.055) | 0 (0, 0) | 0.085 (0.076, 0.094) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.381 (0.206, 0.555) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| all | TC3 | time | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) |
| all | TC3 | n | 8 (6, 11) | 2 (1, 2) | 0 (0, 1) | 2 (1, 2) | 2 (1, 4) | 2 (0, 3) | 0 (0, 1) | 1 (0, 3) | 3 (1, 5) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 1 (0, 1) | 0 (0, 0) | 1 (0, 1) | 0 (0, 1) | 0 (0, 2) | 0 (0, 3) | 0 (0, 1) | 0 (0, 2) | 0 (0, 0) | 4 (1, 4) | 1 (1, 2) | 1 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC3 | post_p | 0.66 (0.52, 0.83) | 0.55 (0.52, 0.58) | 0.51 (0.51, 0.51) | 0.53 (0.51, 0.54) | 0.55 (0.54, 0.55) | 0.56 (0.52, 0.63) | 0.54 (0.54, 0.54) | 0.55 (0.53, 0.56) | 0.62 (0.58, 0.67) | NA (NA, NA) | 0.53 (0.53, 0.53) | NA (NA, NA) | NA (NA, NA) | 0.51 (0.51, 0.51) | NA (NA, NA) | 0.53 (0.52, 0.55) | NA (NA, NA) | 0.55 (0.55, 0.55) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.61 (0.58, 0.72) | 0.51 (0.5, 0.62) | 0.6 (0.58, 0.61) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) |
| all | TC3 | rate | 0.084 (0.049, 0.102) | 0 (0, 0.105) | 0 (0, 0) | 0 (0, 0.132) | 0.035 (0, 0.073) | 0 (0, 0) | 0.413 (0.083, 0.744) | 0 (0, 0.126) | 0 (0, 0.029) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0.376 (0.376, 0.376) | 0 (0, 0.309) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.054 (0.011, 0.097) | 0 (0, 0) | 0.235 (0.201, 0.269) | NA (NA, NA) | 0.077 (0.015, 0.084) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC4 | count | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 |
| all | TC4 | time | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) | 7 (5, 10) |
| all | TC4 | n | 13 (7, 15) | 4 (1, 4) | 0 (0, 2) | 0 (0, 1) | 4 (2, 5) | 1 (0, 4) | 0 (0, 0) | 2 (0, 3) | 3 (2, 4) | 0 (0, 0) | 2 (0, 4) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 1 (0, 2) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 1 (1, 4) | 1 (1, 4) | 0 (0, 3) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC4 | post_p | 0.73 (0.61, 0.91) | 0.59 (0.55, 0.67) | 0.52 (0.52, 0.64) | NA (NA, NA) | 0.56 (0.51, 0.59) | 0.55 (0.53, 0.61) | NA (NA, NA) | 0.59 (0.53, 0.67) | 0.56 (0.55, 0.7) | NA (NA, NA) | 0.63 (0.6, 0.64) | 0.56 (0.55, 0.56) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.58 (0.56, 0.64) | 0.55 (0.55, 0.55) | NA (NA, NA) | 0.53 (0.53, 0.53) | 0.61 (0.61, 0.61) | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.54 (0.53, 0.63) | 0.55 (0.54, 0.62) | 0.54 (0.54, 0.54) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) |
| all | TC4 | rate | 0.036 (0, 0.082) | 0 (0, 0.061) | 0 (0, 0.052) | 0 (0, 0) | 0.104 (0, 0.167) | 0.018 (0, 0.079) | NA (NA, NA) | 0.077 (0, 0.151) | 0 (0, 0.016) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0.191) | NA (NA, NA) | 0 (0, 0.118) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.09) | 0 (0, 0.081) | 0 (0, 0.12) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC5 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| all | TC5 | time | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) | 5 (5, 9) |
| all | TC5 | n | 10 (8, 10) | 0 (0, 3) | 0 (0, 1) | 1 (1, 5) | 4 (2, 6) | 2 (0, 2) | 1 (0, 3) | 2 (0, 4) | 3 (3, 4) | 0 (0, 0) | 0 (0, 1) | 1 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 2 (1, 3) | 2 (2, 3) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC5 | post_p | 0.64 (0.56, 0.7) | 0.73 (0.73, 0.73) | 0.51 (0.51, 0.51) | 0.74 (0.6, 0.87) | 0.55 (0.53, 0.61) | 0.53 (0.53, 0.53) | 0.53 (0.53, 0.53) | 0.52 (0.52, 0.52) | 0.52 (0.51, 0.53) | NA (NA, NA) | NA (NA, NA) | 0.6 (0.6, 0.6) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.57 (0.57, 0.57) | NA (NA, NA) | NA (NA, NA) | 0.51 (0.51, 0.51) | 0.54 (0.54, 0.54) | NA (NA, NA) | NA (NA, NA) | 0.53 (0.52, 0.53) | 0.55 (0.53, 0.56) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC5 | rate | 0.062 (0.044, 0.076) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.025) | 0 (0, 0.025) | 0.493 (0.188, 0.798) | 0 (0, 0) | 0.039 (0.008, 0.071) | 0 (0, 0.03) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0.139 (0.139, 0.139) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0.075) | 0 (0, 0.238) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| AR- & TP53- | TC1 | count | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | time | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | n | 15 (12, 21) | 4 (3, 7) | 0 (0, 2) | 2 (0, 5) | 3 (0, 5) | 0 (0, 0) | 1 (0, 4) | 1 (0, 2) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | post_p | 0.76 (0.71, 0.83) | 0.7 (0.57, 0.81) | 0.57 (0.51, 0.6) | 0.62 (0.55, 0.76) | 0.62 (0.53, 0.73) | NA (NA, NA) | 0.58 (0.51, 0.66) | 0.55 (0.52, 0.68) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | r_prob | 0.41 (0.41, 0.41) | 0.22 (0.22, 0.22) | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | rate | 0.084 (0.057, 0.104) | 0.059 (0.006, 0.097) | 0 (0, 0.1) | 0.024 (0, 0.084) | 0 (0, 0.068) | NA (NA, NA) | 0 (0, 0.06) | 0.064 (0, 0.3) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | time | 12 (10, 18) | 12 (10, 18) | 12 (10, 18) | 12 (10, 18) | 12 (10, 18) | 12 (10, 18) | 12 (10, 18) | 12 (10, 18) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | n | 18 (15, 25) | 4 (2, 6) | 1 (0, 2) | 1 (0, 7) | 4 (2, 10) | 0 (0, 0) | 1 (1, 2) | 0 (0, 1) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | post_p | 0.77 (0.74, 0.84) | 0.61 (0.52, 0.75) | 0.61 (0.57, 0.65) | 0.58 (0.52, 0.7) | 0.71 (0.55, 0.81) | NA (NA, NA) | 0.53 (0.52, 0.68) | 0.56 (0.53, 0.58) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | r_prob | 0.18 (0.18, 0.18) | 0.03 (0.03, 0.03) | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | rate | 0.077 (0.059, 0.094) | 0.055 (0, 0.118) | 0.049 (0, 0.436) | 0.034 (0, 0.113) | 0.044 (0, 0.062) | NA (NA, NA) | 0 (0, 0.026) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | count | 65 | 65 | 65 | 65 | 65 | 65 | 65 | 65 | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | time | 14 (10, 26) | 14 (10, 26) | 14 (10, 26) | 14 (10, 26) | 14 (10, 26) | 14 (10, 26) | 14 (10, 26) | 14 (10, 26) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | n | 19 (12, 40) | 4 (2, 11) | 1 (0, 2) | 2 (0, 5) | 5 (2, 10) | 0 (0, 0) | 2 (1, 5) | 1 (0, 3) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | post_p | 0.79 (0.72, 0.93) | 0.67 (0.52, 0.77) | 0.57 (0.52, 0.67) | 0.59 (0.51, 0.78) | 0.77 (0.57, 0.97) | NA (NA, NA) | 0.6 (0.53, 0.84) | 0.58 (0.53, 0.79) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | rate | 0.081 (0.053, 0.102) | 0.078 (0, 0.136) | 0 (0, 0.249) | 0.055 (0, 0.137) | 0.005 (0, 0.052) | 0 (0, 0) | 0 (0, 0.09) | 0 (0, 0.046) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | count | 62 | 62 | 62 | 62 | 62 | 62 | 62 | 62 | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | time | 14 (9, 27) | 14 (9, 27) | 14 (9, 27) | 14 (9, 27) | 14 (9, 27) | 14 (9, 27) | 14 (9, 27) | 14 (9, 27) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | n | 20 (15, 39) | 5 (3, 12) | 1 (0, 3) | 2 (0, 5) | 5 (1, 9) | 0 (0, 0) | 3 (0, 5) | 1 (0, 3) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | post_p | 0.82 (0.72, 0.94) | 0.66 (0.52, 0.82) | 0.55 (0.52, 0.64) | 0.58 (0.52, 0.78) | 0.7 (0.54, 0.94) | NA (NA, NA) | 0.59 (0.53, 0.81) | 0.56 (0.52, 0.68) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | rate | 0.072 (0.051, 0.1) | 0.066 (0, 0.116) | 0.063 (0, 0.222) | 0.056 (0, 0.132) | 0.02 (0, 0.08) | NA (NA, NA) | 0 (0, 0.083) | 0 (0, 0.149) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | count | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | time | 14 (11, 17) | 14 (11, 17) | 14 (11, 17) | 14 (11, 17) | 14 (11, 17) | 14 (11, 17) | 14 (11, 17) | 14 (11, 17) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | n | 20 (12, 23) | 4 (4, 6) | 0 (0, 1) | 3 (2, 5) | 2 (1, 4) | 0 (0, 0) | 2 (1, 4) | 0 (0, 2) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | post_p | 0.78 (0.73, 0.87) | 0.74 (0.53, 0.86) | 0.61 (0.56, 0.69) | 0.54 (0.51, 0.74) | 0.57 (0.52, 0.62) | NA (NA, NA) | 0.6 (0.53, 0.63) | 0.55 (0.54, 0.59) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | rate | 0.085 (0.026, 0.096) | 0.071 (0.026, 0.102) | 0 (0, 0.073) | 0.082 (0, 0.114) | 0 (0, 0.139) | 1.141 (1.141, 1.141) | 0 (0, 0.092) | 0.067 (0, 0.307) | ||||||||||||||||||||||||
| HRD+ | TC1 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||
| HRD+ | TC1 | time | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | ||||||||||||||||
| HRD+ | TC1 | n | 11 (11, 11) | 0 (0, 0) | 3 (3, 3) | 6 (6, 6) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 1 (1, 1) | 3 (3, 3) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC1 | post_p | 0.79 (0.79, 0.79) | NA (NA, NA) | 0.67 (0.67, 0.67) | 0.77 (0.77, 0.77) | NA (NA, NA) | 0.58 (0.58, 0.58) | NA (NA, NA) | 0.89 (0.89, 0.89) | 0.51 (0.51, 0.51) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC1 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC1 | rate | 0.057 (0.057, 0.057) | NA (NA, NA) | 0.066 (0.066, 0.066) | 0.019 (0.019, 0.019) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0.082 (0.082, 0.082) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC3 | count | 220 | 220 | 220 | 220 | 220 | 220 | 220 | 220 | 220 | 220 | 220 | 220 | 220 | 220 | 220 | 220 | ||||||||||||||||
| HRD+ | TC3 | time | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | ||||||||||||||||
| HRD+ | TC3 | n | 11 (8, 14) | 0 (0, 0) | 5 (3, 9) | 2 (0, 4) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 1 (0, 3) | 4 (1, 6) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC3 | post_p | 0.95 (0.82, 1) | 0.53 (0.51, 0.55) | 0.83 (0.62, 0.96) | 0.65 (0.53, 0.83) | NA (NA, NA) | 0.6 (0.52, 0.75) | NA (NA, NA) | 0.61 (0.52, 0.76) | 0.75 (0.57, 0.93) | 0.54 (0.54, 0.54) | 0.56 (0.52, 0.62) | NA (NA, NA) | 0.54 (0.52, 0.59) | NA (NA, NA) | 0.53 (0.53, 0.53) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC3 | r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| HRD+ | TC3 | rate | 0.033 (0.017, 0.053) | 0 (0, 2.172) | 0.028 (0, 0.068) | 0.024 (0, 0.075) | 0.024 (0.005, 0.043) | 0 (0, 0.083) | 0 (0, 0.073) | 0 (0, 0.103) | 0.026 (0, 0.072) | 0 (0, 0.102) | 0 (0, 0.105) | 0 (0, 0.482) | 0 (0, 0.173) | 0.087 (0.017, 0.156) | 0.058 (0, 0.143) | 0 (0, 0.264) | ||||||||||||||||
| HRD+ | TC4 | count | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | 219 | ||||||||||||||||
| HRD+ | TC4 | time | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | 30 (24, 35) | ||||||||||||||||
| HRD+ | TC4 | n | 11 (8, 16) | 0 (0, 0) | 5 (3, 9) | 2 (1, 5) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 1 (0, 3) | 3 (1, 6) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC4 | post_p | 0.96 (0.76, 1) | 0.56 (0.55, 0.58) | 0.82 (0.62, 0.96) | 0.68 (0.54, 0.84) | NA (NA, NA) | 0.6 (0.52, 0.79) | 0.6 (0.6, 0.6) | 0.6 (0.52, 0.79) | 0.71 (0.56, 0.89) | 0.67 (0.67, 0.67) | 0.58 (0.51, 0.64) | NA (NA, NA) | 0.56 (0.52, 0.58) | NA (NA, NA) | NA (NA, NA) | 0.52 (0.52, 0.52) | ||||||||||||||||
| HRD+ | TC4 | r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| HRD+ | TC4 | rate | 0.033 (0.014, 0.058) | 0 (0, 0.013) | 0.031 (0, 0.069) | 0.02 (0, 0.072) | 0 (0, 0) | 0 (0, 0.071) | 0 (0, 0.456) | 0 (0, 0.095) | 0.028 (0, 0.076) | 0.027 (0, 0.18) | 0 (0, 0.094) | 0 (0, 0.388) | 0 (0, 0.82) | 0.166 (0.033, 0.299) | 0.081 (0.016, 0.109) | 0 (0, 0.101) | ||||||||||||||||
| TP53+ | TC1 | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | ||||||||||||||||
| TP53+ | TC1 | time | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | ||||||||||||||||
| TP53+ | TC1 | n | 5 (5, 7) | 8 (4, 10) | 0 (0, 2) | 5 (3, 5) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 6 (4, 7) | 4 (3, 6) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC1 | post_p | 0.71 (0.6, 0.81) | 0.8 (0.7, 0.87) | 0.58 (0.52, 0.65) | 0.56 (0.51, 0.69) | NA (NA, NA) | 0.56 (0.56, 0.56) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.68 (0.56, 0.82) | 0.72 (0.54, 0.87) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC1 | r_prob | 0.31 (0.31, 0.31) | 0.13 (0.13, 0.13) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC1 | rate | 0.088 (0.069, 0.108) | 0.074 (0.05, 0.076) | 0.035 (0.007, 0.064) | 0.079 (0.035, 0.129) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.062 (0.035, 0.1) | 0.066 (0.013, 0.113) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC2 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||
| TP53+ | TC2 | time | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | 24 (22, 26) | ||||||||||||||||
| TP53+ | TC2 | n | 6 (6, 7) | 4 (4, 5) | 1 (1, 1) | 4 (4, 5) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 4 (4, 5) | 5 (5, 5) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | post_p | 0.78 (0.76, 0.79) | 0.68 (0.54, 0.81) | 0.67 (0.57, 0.76) | 0.58 (0.53, 0.62) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.57 (0.57, 0.57) | NA (NA, NA) | 0.8 (0.79, 0.81) | 0.61 (0.54, 0.68) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC2 | r_prob | 0.17 (0.17, 0.17) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | rate | 0.069 (0.062, 0.076) | 0.073 (0.034, 0.112) | 0 (0, 0) | 0.119 (0.118, 0.12) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.137 (0.137, 0.137) | NA (NA, NA) | 0.061 (0.034, 0.088) | 0.074 (0.062, 0.086) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC3 | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | ||||||||||||||||
| TP53+ | TC3 | time | 21 (16, 24) | 21 (16, 24) | 21 (16, 24) | 21 (16, 24) | 21 (16, 24) | 21 (16, 24) | 21 (16, 24) | 21 (16, 24) | 21 (16, 24) | 21 (16, 24) | 21 (16, 24) | 21 (16, 24) | 21 (16, 24) | 21 (16, 24) | 21 (16, 24) | 21 (16, 24) | ||||||||||||||||
| TP53+ | TC3 | n | 8 (4, 11) | 6 (5, 8) | 2 (0, 4) | 4 (2, 6) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 1 (0, 2) | 1 (0, 2) | 0 (0, 0) | 4 (4, 6) | 4 (2, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC3 | post_p | 0.77 (0.68, 0.82) | 0.79 (0.73, 0.88) | 0.54 (0.52, 0.63) | 0.7 (0.6, 0.77) | NA (NA, NA) | 0.63 (0.58, 0.64) | NA (NA, NA) | 0.63 (0.6, 0.68) | 0.59 (0.59, 0.59) | NA (NA, NA) | 0.69 (0.56, 0.78) | 0.61 (0.54, 0.72) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC3 | r_prob | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TP53+ | TC3 | rate | 0.081 (0.04, 0.099) | 0.053 (0.039, 0.07) | 0.106 (0.026, 0.128) | 0.026 (0, 0.091) | 0 (0, 0) | 0 (0, 0.069) | NA (NA, NA) | 0 (0, 0.053) | 0.085 (0, 0.228) | NA (NA, NA) | 0.07 (0.039, 0.096) | 0.058 (0.043, 0.111) | 0.173 (0.173, 0.173) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC4 | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | ||||||||||||||||
| TP53+ | TC4 | time | 22 (17, 31) | 22 (17, 31) | 22 (17, 31) | 22 (17, 31) | 22 (17, 31) | 22 (17, 31) | 22 (17, 31) | 22 (17, 31) | 22 (17, 31) | 22 (17, 31) | 22 (17, 31) | 22 (17, 31) | 22 (17, 31) | 22 (17, 31) | 22 (17, 31) | 22 (17, 31) | ||||||||||||||||
| TP53+ | TC4 | n | 8 (4, 15) | 8 (6, 9) | 2 (1, 4) | 5 (4, 6) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 1 (0, 2) | 0 (0, 2) | 0 (0, 0) | 5 (3, 8) | 2 (2, 5) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | ||||||||||||||||
| TP53+ | TC4 | post_p | 0.75 (0.64, 0.89) | 0.85 (0.8, 0.93) | 0.59 (0.55, 0.68) | 0.71 (0.55, 0.83) | NA (NA, NA) | 0.56 (0.52, 0.61) | NA (NA, NA) | 0.6 (0.6, 0.6) | 0.54 (0.52, 0.56) | NA (NA, NA) | 0.66 (0.58, 0.77) | 0.77 (0.64, 0.91) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC4 | r_prob | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TP53+ | TC4 | rate | 0.07 (0.063, 0.09) | 0.055 (0.035, 0.088) | 0.023 (0, 0.073) | 0.086 (0.074, 0.115) | NA (NA, NA) | 0.121 (0.024, 0.217) | NA (NA, NA) | 0 (0, 0.039) | 0.079 (0.065, 0.093) | NA (NA, NA) | 0.078 (0.051, 0.098) | 0.044 (0.035, 0.053) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.092 (0.092, 0.092) | ||||||||||||||||
| TP53+ | TC5 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||||||||||
| TP53+ | TC5 | time | 18 (16, 24) | 18 (16, 24) | 18 (16, 24) | 18 (16, 24) | 18 (16, 24) | 18 (16, 24) | 18 (16, 24) | 18 (16, 24) | 18 (16, 24) | 18 (16, 24) | 18 (16, 24) | 18 (16, 24) | 18 (16, 24) | 18 (16, 24) | 18 (16, 24) | 18 (16, 24) | ||||||||||||||||
| TP53+ | TC5 | n | 9 (7, 12) | 6 (5, 8) | 2 (1, 2) | 3 (2, 8) | 0 (0, 0) | 1 (0, 1) | 0 (0, 0) | 1 (0, 1) | 0 (0, 0) | 0 (0, 0) | 5 (3, 6) | 3 (1, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC5 | post_p | 0.78 (0.72, 0.85) | 0.74 (0.55, 0.77) | 0.58 (0.52, 0.61) | 0.81 (0.76, 0.82) | NA (NA, NA) | 0.6 (0.6, 0.6) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.8 (0.62, 0.84) | 0.59 (0.57, 0.6) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC5 | r_prob | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC5 | rate | 0.059 (0.038, 0.064) | 0.098 (0.066, 0.112) | 0.083 (0.017, 0.179) | 0.047 (0.009, 0.075) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0.063 (0.048, 0.109) | 0.101 (0.02, 0.117) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC1 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||
| TEfus+ | TC1 | time | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | 20 (20, 21) | ||||||||||||||||
| TEfus+ | TC1 | n | 2 (0, 3) | 3 (2, 4) | 2 (0, 3) | 6 (5, 6) | 4 (3, 5) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 2 (1, 4) | 2 (1, 2) | 3 (3, 3) | 5 (4, 6) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC1 | post_p | 0.69 (0.69, 0.69) | 0.62 (0.53, 0.71) | 0.63 (0.63, 0.63) | 0.74 (0.71, 0.77) | 0.71 (0.67, 0.75) | NA (NA, NA) | NA (NA, NA) | 0.51 (0.51, 0.51) | 0.81 (0.73, 0.9) | 0.6 (0.56, 0.65) | 0.66 (0.56, 0.76) | 0.72 (0.69, 0.75) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC1 | r_prob | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC1 | rate | 0.07 (0.07, 0.07) | 0.115 (0.075, 0.154) | 0.082 (0.082, 0.082) | 0.055 (0.053, 0.056) | 0.052 (0.049, 0.054) | NA (NA, NA) | 0.646 (0.646, 0.646) | 0.111 (0.111, 0.111) | 0.066 (0.027, 0.105) | 0 (0, 0) | 0.081 (0.039, 0.122) | 0.04 (0.032, 0.048) | 0.159 (0.159, 0.159) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC3 | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | ||||||||||||||||
| TEfus+ | TC3 | time | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | 22 (15, 32) | ||||||||||||||||
| TEfus+ | TC3 | n | 1 (0, 3) | 4 (3, 5) | 3 (1, 3) | 5 (2, 8) | 4 (1, 6) | 2 (0, 4) | 0 (0, 0) | 0 (0, 2) | 2 (2, 4) | 1 (1, 2) | 7 (3, 12) | 4 (3, 8) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC3 | post_p | 0.6 (0.54, 0.8) | 0.7 (0.53, 0.76) | 0.66 (0.54, 0.79) | 0.78 (0.64, 0.89) | 0.73 (0.67, 0.94) | 0.69 (0.62, 0.84) | NA (NA, NA) | 0.54 (0.54, 0.54) | 0.6 (0.52, 0.68) | 0.59 (0.59, 0.65) | 0.71 (0.53, 0.82) | 0.74 (0.63, 0.82) | 0.58 (0.57, 0.6) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TEfus+ | TC3 | rate | 0.058 (0.017, 0.127) | 0.071 (0.046, 0.106) | 0.017 (0, 0.063) | 0.062 (0.025, 0.078) | 0.023 (0, 0.041) | 0 (0, 0.018) | 0.041 (0.041, 0.041) | 0.048 (0.01, 0.086) | 0.065 (0.017, 0.156) | 0 (0, 0.092) | 0.077 (0.046, 0.126) | 0.051 (0, 0.072) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC4 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||||||||||
| TEfus+ | TC4 | time | 19 (16, 25) | 19 (16, 25) | 19 (16, 25) | 19 (16, 25) | 19 (16, 25) | 19 (16, 25) | 19 (16, 25) | 19 (16, 25) | 19 (16, 25) | 19 (16, 25) | 19 (16, 25) | 19 (16, 25) | 19 (16, 25) | 19 (16, 25) | 19 (16, 25) | 19 (16, 25) | ||||||||||||||||
| TEfus+ | TC4 | n | 1 (0, 1) | 4 (2, 5) | 2 (0, 2) | 4 (2, 5) | 2 (2, 4) | 1 (0, 3) | 0 (0, 0) | 0 (0, 1) | 3 (1, 4) | 0 (0, 2) | 7 (5, 9) | 3 (3, 4) | 1 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC4 | post_p | 0.53 (0.53, 0.53) | 0.74 (0.57, 0.77) | 0.53 (0.51, 0.56) | 0.77 (0.69, 0.78) | 0.67 (0.54, 0.92) | 0.58 (0.57, 0.59) | NA (NA, NA) | 0.54 (0.54, 0.54) | 0.62 (0.53, 0.71) | NA (NA, NA) | 0.72 (0.56, 0.76) | 0.59 (0.54, 0.77) | 0.57 (0.57, 0.57) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TEfus+ | TC4 | rate | 0 (0, 0) | 0.088 (0.018, 0.095) | 0.089 (0.018, 0.16) | 0 (0, 0.031) | 0 (0, 0.043) | 0.009 (0.002, 0.016) | NA (NA, NA) | 0 (0, 0) | 0.083 (0.05, 0.116) | 0.118 (0.118, 0.118) | 0.094 (0.094, 0.101) | 0.055 (0.048, 0.062) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC1 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||||||||||
| PI3K+ | TC1 | time | 20 (18, 22) | 20 (18, 22) | 20 (18, 22) | 20 (18, 22) | 20 (18, 22) | 20 (18, 22) | 20 (18, 22) | 20 (18, 22) | 20 (18, 22) | 20 (18, 22) | 20 (18, 22) | 20 (18, 22) | 20 (18, 22) | 20 (18, 22) | 20 (18, 22) | 20 (18, 22) | ||||||||||||||||
| PI3K+ | TC1 | n | 8 (4, 11) | 4 (3, 5) | 4 (3, 5) | 4 (4, 4) | 0 (0, 0) | 4 (3, 4) | 2 (1, 2) | 2 (1, 3) | 2 (2, 2) | 1 (1, 1) | 0 (0, 0) | 2 (1, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC1 | post_p | 0.79 (0.78, 0.79) | 0.55 (0.55, 0.55) | 0.87 (0.86, 0.87) | 0.66 (0.6, 0.72) | NA (NA, NA) | 0.53 (0.51, 0.56) | 0.52 (0.52, 0.52) | NA (NA, NA) | 0.6 (0.6, 0.6) | 0.58 (0.54, 0.61) | NA (NA, NA) | 0.69 (0.57, 0.8) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC1 | r_prob | 0.22 (0.22, 0.22) | 0.22 (0.22, 0.22) | 0.13 (0.13, 0.13) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.14 (0.14, 0.14) | 0.14 (0.14, 0.14) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC1 | rate | 0.045 (0.037, 0.054) | 0.087 (0.085, 0.089) | 0 (0, 0) | 0.088 (0.064, 0.113) | NA (NA, NA) | 0.056 (0.029, 0.083) | 0.102 (0.02, 0.184) | 0.244 (0.239, 0.25) | 0.861 (0.245, 1.476) | 0.031 (0.006, 0.057) | NA (NA, NA) | 0.041 (0.008, 0.074) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC2 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||||||||||
| PI3K+ | TC2 | time | 20 (16, 24) | 20 (16, 24) | 20 (16, 24) | 20 (16, 24) | 20 (16, 24) | 20 (16, 24) | 20 (16, 24) | 20 (16, 24) | 20 (16, 24) | 20 (16, 24) | 20 (16, 24) | 20 (16, 24) | 20 (16, 24) | 20 (16, 24) | 20 (16, 24) | 20 (16, 24) | ||||||||||||||||
| PI3K+ | TC2 | n | 9 (8, 10) | 5 (3, 7) | 4 (3, 6) | 4 (4, 4) | 0 (0, 0) | 2 (2, 3) | 0 (0, 0) | 1 (0, 2) | 1 (1, 2) | 1 (0, 3) | 0 (0, 0) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | ||||||||||||||||
| PI3K+ | TC2 | post_p | 0.75 (0.72, 0.81) | 0.57 (0.57, 0.75) | 0.73 (0.57, 0.84) | 0.56 (0.51, 0.8) | NA (NA, NA) | 0.6 (0.54, 0.66) | NA (NA, NA) | 0.62 (0.53, 0.71) | 0.66 (0.58, 0.73) | 0.52 (0.52, 0.54) | NA (NA, NA) | 0.66 (0.65, 0.82) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC2 | r_prob | 0.03 (0.03, 0.03) | 0.03 (0.03, 0.03) | 0.07 (0.07, 0.07) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.21 (0.21, 0.21) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC2 | rate | 0.057 (0.049, 0.063) | 0.097 (0.063, 0.117) | 0.043 (0.009, 0.085) | 0.095 (0.054, 0.102) | NA (NA, NA) | 0 (0, 0.208) | NA (NA, NA) | 0.228 (0.137, 0.318) | 0 (0, 0.032) | 0.081 (0.016, 0.146) | NA (NA, NA) | 0.042 (0.008, 0.047) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC3 | count | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | ||||||||||||||||
| PI3K+ | TC3 | time | 22 (13, 28) | 22 (13, 28) | 22 (13, 28) | 22 (13, 28) | 22 (13, 28) | 22 (13, 28) | 22 (13, 28) | 22 (13, 28) | 22 (13, 28) | 22 (13, 28) | 22 (13, 28) | 22 (13, 28) | 22 (13, 28) | 22 (13, 28) | 22 (13, 28) | 22 (13, 28) | ||||||||||||||||
| PI3K+ | TC3 | n | 6 (4, 9) | 4 (3, 6) | 7 (5, 8) | 4 (3, 6) | 0 (0, 0) | 1 (0, 3) | 1 (0, 2) | 0 (0, 2) | 0 (0, 1) | 1 (1, 2) | 0 (0, 0) | 3 (2, 6) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC3 | post_p | 0.73 (0.54, 0.87) | 0.64 (0.59, 0.71) | 0.76 (0.68, 0.86) | 0.76 (0.63, 0.85) | NA (NA, NA) | 0.6 (0.55, 0.69) | 0.6 (0.57, 0.67) | 0.67 (0.64, 0.71) | 0.56 (0.54, 0.58) | 0.57 (0.53, 0.72) | NA (NA, NA) | 0.69 (0.61, 0.83) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| PI3K+ | TC3 | rate | 0.064 (0.032, 0.11) | 0.055 (0.032, 0.091) | 0.066 (0.033, 0.104) | 0.054 (0.047, 0.074) | 0 (0, 0) | 0 (0, 0.06) | 0 (0, 0.035) | 0 (0, 0.067) | 0.025 (0, 0.055) | 0 (0, 0.081) | NA (NA, NA) | 0.053 (0, 0.099) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC4 | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | ||||||||||||||||
| PI3K+ | TC4 | time | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | 18 (16, 22) | ||||||||||||||||
| PI3K+ | TC4 | n | 5 (4, 8) | 4 (2, 5) | 6 (4, 8) | 4 (2, 5) | 0 (0, 0) | 2 (2, 4) | 0 (0, 2) | 0 (0, 1) | 1 (0, 1) | 0 (0, 2) | 0 (0, 0) | 4 (2, 5) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC4 | post_p | 0.66 (0.52, 0.85) | 0.64 (0.53, 0.71) | 0.65 (0.55, 0.75) | 0.59 (0.54, 0.7) | NA (NA, NA) | 0.54 (0.51, 0.77) | 0.6 (0.58, 0.69) | 0.58 (0.58, 0.58) | 0.53 (0.51, 0.54) | 0.57 (0.57, 0.57) | NA (NA, NA) | 0.7 (0.54, 0.89) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| PI3K+ | TC4 | rate | 0.074 (0.053, 0.119) | 0.074 (0.023, 0.096) | 0.08 (0.063, 0.088) | 0.08 (0, 0.103) | NA (NA, NA) | 0.033 (0.028, 0.126) | 0 (0, 0.129) | 0 (0, 0) | 0 (0, 0) | 0.245 (0.13, 0.359) | NA (NA, NA) | 0.053 (0.01, 0.095) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC5 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||
| PI3K+ | TC5 | time | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | 23 (23, 23) | ||||||||||||||||
| PI3K+ | TC5 | n | 5 (5, 5) | 5 (5, 5) | 7 (7, 7) | 7 (7, 7) | 0 (0, 0) | 2 (2, 2) | 1 (1, 1) | 0 (0, 0) | 1 (1, 1) | 1 (1, 1) | 0 (0, 0) | 3 (3, 3) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC5 | post_p | 0.51 (0.51, 0.51) | 0.84 (0.84, 0.84) | 0.83 (0.83, 0.83) | 0.87 (0.87, 0.87) | NA (NA, NA) | 0.51 (0.51, 0.51) | NA (NA, NA) | NA (NA, NA) | 0.56 (0.56, 0.56) | NA (NA, NA) | NA (NA, NA) | 0.6 (0.6, 0.6) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC5 | r_prob | 0.38 (0.38, 0.38) | 0.38 (0.38, 0.38) | 0.33 (0.33, 0.33) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC5 | rate | 0.137 (0.137, 0.137) | 0.047 (0.047, 0.047) | 0.051 (0.051, 0.051) | 0.069 (0.069, 0.069) | NA (NA, NA) | 0.098 (0.098, 0.098) | 0.15 (0.15, 0.15) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0.067 (0.067, 0.067) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| signature | treatment | var | —– | —-+ | —+- | —++ | –+– | –+-+ | –++- | –+++ | -+— | -+–+ | -+-+- | -+-++ | -++– | -++-+ | -+++- | -++++ | +—- | +—+ | +–+- | +–++ | +-+– | +-+-+ | +-++- | +-+++ | ++— | ++–+ | ++-+- | ++-++ | +++– | +++-+ | ++++- | +++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | TC2 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| all | TC2 | time | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) | 8 (6, 14) |
| all | TC2 | n | 11 (8, 14) | 3 (2, 3) | 0 (0, 2) | 2 (0, 3) | 2 (0, 6) | 3 (2, 4) | 1 (1, 2) | 2 (1, 2) | 3 (1, 5) | 0 (0, 1) | 2 (0, 6) | 1 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 2) | 1 (0, 3) | 0 (0, 1) | 2 (0, 2) | 0 (0, 1) | 0 (0, 2) | 0 (0, 0) | 4 (2, 6) | 1 (0, 2) | 1 (0, 3) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | post_p | 0.4 (0.25, 0.47) | 0.39 (0.36, 0.4) | NA (NA, NA) | 0.25 (0.21, 0.28) | 0.27 (0.2, 0.33) | 0.41 (0.34, 0.46) | 0.4 (0.31, 0.46) | 0.39 (0.36, 0.45) | 0.34 (0.34, 0.34) | NA (NA, NA) | 0.37 (0.32, 0.42) | NA (NA, NA) | NA (NA, NA) | 0.43 (0.43, 0.43) | NA (NA, NA) | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | NA (NA, NA) | 0.46 (0.46, 0.46) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.44 (0.28, 0.48) | 0.49 (0.49, 0.49) | 0.48 (0.47, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | r_prob | 0.18 (0.18, 0.18) | 0.03 (0.03, 0.03) | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0.17 (0.17, 0.17) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | rate | 0.133 (0.12, 0.147) | 0.293 (0.238, 0.344) | 0.969 (0.969, 0.969) | 0.507 (0.34, 0.673) | 0.313 (0.239, 0.386) | 0.114 (0.105, 0.403) | 0.439 (0.431, 0.503) | 0.153 (0.131, 0.471) | 0.192 (0.128, 0.257) | 0 (0, 0) | 0.157 (0.137, 0.177) | 0 (0, 0) | NA (NA, NA) | 1.537 (1.537, 1.537) | NA (NA, NA) | 0.432 (0.432, 0.432) | 0.068 (0.014, 0.123) | 0 (0, 0) | 0.251 (0.05, 0.451) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0.247 (0.183, 0.283) | 0.264 (0.246, 0.282) | 0.039 (0.008, 0.071) | NA (NA, NA) | 0.165 (0.163, 0.167) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC5 | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| all | TC5 | time | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) |
| all | TC5 | n | 13 (4, 15) | 4 (3, 6) | 1 (0, 2) | 1 (0, 4) | 7 (2, 11) | 4 (2, 7) | 0 (0, 1) | 2 (1, 4) | 4 (3, 5) | 0 (0, 0) | 1 (0, 3) | 1 (0, 2) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 2) | 0 (0, 2) | 0 (0, 1) | 0 (0, 1) | 4 (1, 5) | 2 (1, 3) | 1 (0, 2) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC5 | post_p | 0.25 (0.06, 0.46) | 0.38 (0.29, 0.4) | 0.31 (0.31, 0.31) | 0.4 (0.34, 0.45) | 0.46 (0.41, 0.48) | 0.23 (0.13, 0.39) | 0.43 (0.42, 0.43) | 0.34 (0.26, 0.45) | 0.43 (0.3, 0.48) | NA (NA, NA) | 0.45 (0.36, 0.48) | 0.47 (0.47, 0.47) | NA (NA, NA) | 0.49 (0.49, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.5 (0.5, 0.5) | 0.38 (0.38, 0.38) | NA (NA, NA) | NA (NA, NA) | 0.38 (0.33, 0.41) | 0.42 (0.36, 0.48) | 0.44 (0.44, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC5 | rate | 0.176 (0.129, 0.221) | 0.208 (0.128, 0.253) | 0.286 (0.2, 0.582) | 0.365 (0.121, 0.811) | 0.089 (0.059, 0.123) | 0.222 (0.121, 0.393) | 0.525 (0.221, 0.83) | 0.33 (0.195, 0.513) | 0.129 (0.118, 0.345) | NA (NA, NA) | 0.187 (0.037, 0.204) | 0 (0, 0.17) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0.166 (0.157, 0.176) | NA (NA, NA) | 0 (0, 0) | 0.296 (0.153, 0.439) | 0.221 (0.221, 0.221) | 0.068 (0.068, 0.068) | 0.209 (0.124, 0.282) | 0.17 (0.104, 0.453) | 0.119 (0.116, 0.397) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| AR- & TP53- | TC1 | count | 77 | 77 | 77 | 77 | 77 | 77 | 77 | 77 | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | time | 15 (9, 32) | 15 (9, 32) | 15 (9, 32) | 15 (9, 32) | 15 (9, 32) | 15 (9, 32) | 15 (9, 32) | 15 (9, 32) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | n | 21 (14, 47) | 6 (3, 13) | 1 (0, 3) | 3 (0, 7) | 6 (3, 11) | 0 (0, 0) | 3 (1, 5) | 1 (0, 3) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | post_p | 0.34 (0.13, 0.47) | 0.4 (0.22, 0.48) | 0.43 (0.35, 0.48) | 0.41 (0.24, 0.48) | 0.38 (0.14, 0.48) | NA (NA, NA) | 0.41 (0.23, 0.49) | 0.43 (0.33, 0.48) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | r_prob | 0.41 (0.41, 0.41) | 0.22 (0.22, 0.22) | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC1 | rate | 0.124 (0.106, 0.166) | 0.15 (0.103, 0.266) | 0.282 (0.093, 0.961) | 0.174 (0.112, 0.363) | 0.146 (0.082, 0.261) | 0.119 (0.119, 0.119) | 0.165 (0.09, 0.407) | 0.143 (0.012, 0.601) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | count | 94 | 94 | 94 | 94 | 94 | 94 | 94 | 94 | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | time | 15 (9, 30) | 15 (9, 30) | 15 (9, 30) | 15 (9, 30) | 15 (9, 30) | 15 (9, 30) | 15 (9, 30) | 15 (9, 30) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | n | 19 (14, 44) | 5 (2, 13) | 1 (0, 3) | 3 (0, 7) | 5 (2, 10) | 0 (0, 0) | 2 (0, 7) | 1 (0, 3) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | post_p | 0.31 (0.1, 0.45) | 0.39 (0.23, 0.47) | 0.44 (0.37, 0.5) | 0.41 (0.26, 0.49) | 0.38 (0.16, 0.48) | NA (NA, NA) | 0.41 (0.23, 0.49) | 0.41 (0.32, 0.47) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | r_prob | 0.18 (0.18, 0.18) | 0.03 (0.03, 0.03) | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC2 | rate | 0.133 (0.112, 0.172) | 0.152 (0.099, 0.304) | 0.186 (0.08, 0.588) | 0.189 (0.102, 0.511) | 0.132 (0.084, 0.349) | NA (NA, NA) | 0.161 (0.081, 0.458) | 0.209 (0.035, 0.702) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | time | 11 (10, 11) | 11 (10, 11) | 11 (10, 11) | 11 (10, 11) | 11 (10, 11) | 11 (10, 11) | 11 (10, 11) | 11 (10, 11) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | n | 14 (11, 18) | 4 (4, 6) | 0 (0, 1) | 3 (2, 4) | 3 (2, 4) | 0 (0, 0) | 2 (1, 4) | 0 (0, 2) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | post_p | 0.31 (0.27, 0.34) | 0.22 (0.14, 0.31) | NA (NA, NA) | 0.44 (0.39, 0.49) | 0.46 (0.38, 0.49) | NA (NA, NA) | 0.41 (0.34, 0.48) | NA (NA, NA) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC3 | rate | 0.119 (0.107, 0.137) | 0.321 (0.227, 0.498) | 0 (0, 0) | 0.143 (0.126, 0.165) | 0.141 (0.078, 0.544) | NA (NA, NA) | 0.128 (0.085, 1.444) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | count | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | time | 12 (9, 16) | 12 (9, 16) | 12 (9, 16) | 12 (9, 16) | 12 (9, 16) | 12 (9, 16) | 12 (9, 16) | 12 (9, 16) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | n | 18 (11, 20) | 4 (2, 8) | 0 (0, 3) | 1 (1, 5) | 3 (2, 6) | 0 (0, 0) | 2 (0, 4) | 1 (0, 2) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | post_p | 0.37 (0.17, 0.45) | 0.36 (0.16, 0.44) | 0.47 (0.45, 0.49) | 0.41 (0.36, 0.46) | 0.45 (0.42, 0.48) | NA (NA, NA) | 0.43 (0.38, 0.46) | 0.42 (0.41, 0.45) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||||||||||
| AR- & TP53- | TC4 | rate | 0.127 (0.111, 0.236) | 0.176 (0.149, 0.343) | 0.262 (0.067, 0.637) | 0.277 (0.114, 2.013) | 0.14 (0.09, 0.176) | NA (NA, NA) | 0.135 (0.081, 0.193) | 0.157 (0, 0.256) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | count | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | time | 15 (10, 33) | 15 (10, 33) | 15 (10, 33) | 15 (10, 33) | 15 (10, 33) | 15 (10, 33) | 15 (10, 33) | 15 (10, 33) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | n | 23 (14, 47) | 6 (2, 14) | 1 (0, 3) | 3 (1, 7) | 6 (2, 12) | 0 (0, 0) | 2 (0, 7) | 1 (0, 4) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | post_p | 0.3 (0.08, 0.47) | 0.35 (0.19, 0.47) | 0.43 (0.34, 0.49) | 0.4 (0.24, 0.48) | 0.33 (0.18, 0.48) | NA (NA, NA) | 0.39 (0.23, 0.48) | 0.42 (0.36, 0.47) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||||||||||
| AR- & TP53- | TC5 | rate | 0.13 (0.105, 0.165) | 0.153 (0.1, 0.311) | 0.183 (0.085, 0.405) | 0.179 (0.107, 0.43) | 0.145 (0.084, 0.376) | 0.355 (0.355, 0.355) | 0.16 (0.077, 0.269) | 0.204 (0.06, 0.888) | ||||||||||||||||||||||||
| HRD+ | TC1 | count | 61 | 61 | 61 | 61 | 61 | 61 | 61 | 61 | 61 | 61 | 61 | 61 | 61 | 61 | 61 | 61 | ||||||||||||||||
| HRD+ | TC1 | time | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | ||||||||||||||||
| HRD+ | TC1 | n | 11 (8, 17) | 0 (0, 0) | 6 (3, 9) | 3 (1, 5) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 1 (0, 3) | 3 (2, 6) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC1 | post_p | 0.24 (0.1, 0.47) | NA (NA, NA) | 0.34 (0.15, 0.46) | 0.42 (0.28, 0.49) | 0.5 (0.5, 0.5) | 0.42 (0.34, 0.48) | NA (NA, NA) | 0.4 (0.36, 0.48) | 0.37 (0.2, 0.47) | NA (NA, NA) | 0.43 (0.42, 0.48) | NA (NA, NA) | 0.47 (0.47, 0.48) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC1 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC1 | rate | 0.13 (0.096, 0.182) | 0.651 (0.651, 0.651) | 0.15 (0.104, 0.277) | 0.166 (0.056, 0.557) | 0.199 (0.157, 0.24) | 0.189 (0.067, 0.853) | 0.747 (0.747, 0.747) | 0.191 (0.083, 0.483) | 0.146 (0.077, 0.32) | 0.166 (0.166, 0.166) | 0.207 (0.068, 0.742) | 0.087 (0.017, 0.156) | 0.239 (0, 4.669) | 0.13 (0.13, 0.13) | 0.139 (0.065, 0.282) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC2 | count | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | ||||||||||||||||
| HRD+ | TC2 | time | 31 (24, 35) | 31 (24, 35) | 31 (24, 35) | 31 (24, 35) | 31 (24, 35) | 31 (24, 35) | 31 (24, 35) | 31 (24, 35) | 31 (24, 35) | 31 (24, 35) | 31 (24, 35) | 31 (24, 35) | 31 (24, 35) | 31 (24, 35) | 31 (24, 35) | 31 (24, 35) | ||||||||||||||||
| HRD+ | TC2 | n | 12 (8, 14) | 0 (0, 0) | 6 (2, 9) | 2 (1, 4) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 2 (0, 3) | 4 (2, 6) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC2 | post_p | 0.22 (0.05, 0.42) | NA (NA, NA) | 0.32 (0.16, 0.45) | 0.42 (0.27, 0.48) | 0.45 (0.45, 0.45) | 0.42 (0.28, 0.49) | NA (NA, NA) | 0.42 (0.31, 0.47) | 0.35 (0.17, 0.49) | NA (NA, NA) | 0.43 (0.38, 0.48) | NA (NA, NA) | 0.46 (0.44, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC2 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC2 | rate | 0.133 (0.097, 0.205) | 0.077 (0.077, 0.077) | 0.146 (0.097, 0.26) | 0.152 (0.08, 0.845) | 0.368 (0.319, 0.417) | 0.172 (0.085, 0.579) | 0.268 (0.096, 0.44) | 0.159 (0.062, 0.433) | 0.132 (0.088, 0.381) | 0.158 (0.158, 0.158) | 0.225 (0.051, 0.516) | 0.055 (0.011, 0.1) | 0.154 (0, 1.883) | 0.072 (0.014, 0.13) | 0.098 (0.083, 0.117) | 0.169 (0.107, 0.231) | ||||||||||||||||
| HRD+ | TC5 | count | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | ||||||||||||||||
| HRD+ | TC5 | time | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | 31 (22, 35) | ||||||||||||||||
| HRD+ | TC5 | n | 12 (9, 15) | 0 (0, 0) | 5 (3, 9) | 3 (0, 4) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 1 (0, 3) | 4 (2, 6) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC5 | post_p | 0.23 (0.09, 0.42) | NA (NA, NA) | 0.38 (0.19, 0.47) | 0.41 (0.29, 0.48) | NA (NA, NA) | 0.41 (0.33, 0.47) | NA (NA, NA) | 0.44 (0.29, 0.48) | 0.35 (0.21, 0.48) | NA (NA, NA) | 0.44 (0.41, 0.49) | NA (NA, NA) | 0.48 (0.48, 0.48) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| HRD+ | TC5 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| HRD+ | TC5 | rate | 0.129 (0.096, 0.183) | 5.755 (1.343, 9.428) | 0.131 (0.089, 0.22) | 0.133 (0.078, 0.691) | 0.21 (0.042, 0.413) | 0.186 (0.071, 0.95) | 0 (0, 0.134) | 0.164 (0.068, 0.493) | 0.154 (0.083, 0.345) | 0.197 (0.167, 0.22) | 0.122 (0, 1.938) | 0.106 (0.106, 0.106) | 0.151 (0.047, 0.395) | 0.051 (0.01, 0.102) | NA (NA, NA) | 0.081 (0.06, 0.103) | ||||||||||||||||
| TP53+ | TC1 | count | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | ||||||||||||||||
| TP53+ | TC1 | time | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | ||||||||||||||||
| TP53+ | TC1 | n | 6 (4, 12) | 7 (4, 11) | 2 (0, 4) | 5 (2, 9) | 0 (0, 0) | 0 (0, 3) | 0 (0, 0) | 1 (0, 2) | 0 (0, 1) | 0 (0, 0) | 5 (4, 8) | 4 (2, 7) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC1 | post_p | 0.24 (0.17, 0.41) | 0.35 (0.22, 0.49) | 0.41 (0.27, 0.46) | 0.4 (0.23, 0.47) | 0.46 (0.46, 0.46) | 0.41 (0.27, 0.46) | NA (NA, NA) | 0.42 (0.33, 0.48) | 0.45 (0.4, 0.47) | NA (NA, NA) | 0.39 (0.16, 0.49) | 0.43 (0.2, 0.45) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC1 | r_prob | 0.31 (0.31, 0.31) | 0.13 (0.13, 0.13) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC1 | rate | 0.179 (0.129, 0.332) | 0.151 (0.096, 0.266) | 0.233 (0.103, 0.551) | 0.143 (0.114, 0.252) | 0.238 (0.165, 0.312) | 0.182 (0.061, 0.295) | NA (NA, NA) | 0.155 (0.036, 0.364) | 0.234 (0.082, 3.127) | 0.212 (0.212, 0.212) | 0.15 (0.107, 0.243) | 0.146 (0.098, 0.394) | 0.153 (0.031, 0.625) | 0.288 (0.288, 0.288) | NA (NA, NA) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | count | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | 36 | ||||||||||||||||
| TP53+ | TC2 | time | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | 22 (14, 32) | ||||||||||||||||
| TP53+ | TC2 | n | 7 (4, 12) | 6 (4, 10) | 2 (0, 5) | 5 (2, 10) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 1 (0, 2) | 0 (0, 2) | 0 (0, 0) | 6 (4, 10) | 5 (2, 9) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | post_p | 0.27 (0.1, 0.44) | 0.4 (0.15, 0.48) | 0.4 (0.28, 0.47) | 0.37 (0.2, 0.49) | NA (NA, NA) | 0.43 (0.32, 0.49) | NA (NA, NA) | 0.43 (0.32, 0.49) | 0.44 (0.4, 0.46) | NA (NA, NA) | 0.35 (0.13, 0.48) | 0.35 (0.15, 0.47) | 0.46 (0.46, 0.46) | NA (NA, NA) | 0.5 (0.5, 0.5) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC2 | r_prob | 0.17 (0.17, 0.17) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC2 | rate | 0.169 (0.125, 0.251) | 0.149 (0.104, 0.232) | 0.24 (0.095, 0.482) | 0.141 (0.097, 0.437) | 2.968 (2.968, 2.968) | 0.188 (0.029, 0.833) | NA (NA, NA) | 0.193 (0, 0.53) | 0.226 (0.112, 1.173) | NA (NA, NA) | 0.157 (0.121, 0.228) | 0.171 (0.117, 0.369) | 0.249 (0.149, 0.36) | 0.144 (0.144, 0.144) | 0.08 (0.078, 1.011) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC3 | count | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | ||||||||||||||||
| TP53+ | TC3 | time | 24 (13, 33) | 24 (13, 33) | 24 (13, 33) | 24 (13, 33) | 24 (13, 33) | 24 (13, 33) | 24 (13, 33) | 24 (13, 33) | 24 (13, 33) | 24 (13, 33) | 24 (13, 33) | 24 (13, 33) | 24 (13, 33) | 24 (13, 33) | 24 (13, 33) | 24 (13, 33) | ||||||||||||||||
| TP53+ | TC3 | n | 9 (5, 14) | 6 (4, 11) | 2 (0, 3) | 4 (2, 11) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 3) | 0 (0, 2) | 0 (0, 0) | 4 (4, 10) | 4 (1, 6) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC3 | post_p | 0.44 (0.21, 0.48) | 0.33 (0.14, 0.48) | 0.37 (0.28, 0.48) | 0.35 (0.1, 0.39) | NA (NA, NA) | 0.41 (0.37, 0.46) | NA (NA, NA) | 0.45 (0.43, 0.46) | 0.42 (0.41, 0.47) | NA (NA, NA) | 0.32 (0.21, 0.43) | 0.36 (0.21, 0.47) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC3 | r_prob | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TP53+ | TC3 | rate | 0.135 (0.114, 0.179) | 0.166 (0.104, 0.295) | 0.231 (0.135, 4.249) | 0.19 (0.142, 0.438) | NA (NA, NA) | 0.171 (0.094, 3.996) | NA (NA, NA) | 0.1 (0.088, 2.893) | 0.313 (0.093, 0.445) | NA (NA, NA) | 0.19 (0.138, 0.328) | 0.168 (0.117, 0.365) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC4 | count | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | ||||||||||||||||
| TP53+ | TC4 | time | 20 (14, 29) | 20 (14, 29) | 20 (14, 29) | 20 (14, 29) | 20 (14, 29) | 20 (14, 29) | 20 (14, 29) | 20 (14, 29) | 20 (14, 29) | 20 (14, 29) | 20 (14, 29) | 20 (14, 29) | 20 (14, 29) | 20 (14, 29) | 20 (14, 29) | 20 (14, 29) | ||||||||||||||||
| TP53+ | TC4 | n | 7 (3, 8) | 8 (4, 13) | 2 (1, 3) | 6 (4, 10) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 6 (3, 10) | 3 (1, 6) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | ||||||||||||||||
| TP53+ | TC4 | post_p | 0.44 (0.25, 0.48) | 0.29 (0.23, 0.48) | 0.36 (0.34, 0.47) | 0.34 (0.27, 0.48) | NA (NA, NA) | 0.46 (0.42, 0.48) | NA (NA, NA) | 0.43 (0.43, 0.43) | 0.47 (0.47, 0.47) | NA (NA, NA) | 0.32 (0.16, 0.41) | 0.37 (0.17, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.43 (0.43, 0.43) | ||||||||||||||||
| TP53+ | TC4 | r_prob | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TP53+ | TC4 | rate | 0.141 (0.102, 0.228) | 0.152 (0.131, 0.177) | 0.174 (0.073, 0.294) | 0.137 (0.109, 0.262) | NA (NA, NA) | 0.199 (0.079, 0.387) | NA (NA, NA) | 0.103 (0.015, 0.229) | 0.142 (0.093, 3.857) | NA (NA, NA) | 0.177 (0.124, 0.211) | 0.162 (0.114, 0.52) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0.326 (0.065, 0.586) | ||||||||||||||||
| TP53+ | TC5 | count | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | ||||||||||||||||
| TP53+ | TC5 | time | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | 20 (14, 32) | ||||||||||||||||
| TP53+ | TC5 | n | 7 (5, 12) | 7 (4, 10) | 2 (0, 4) | 5 (2, 10) | 0 (0, 0) | 1 (0, 2) | 0 (0, 0) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 6 (3, 8) | 4 (1, 8) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC5 | post_p | 0.35 (0.11, 0.44) | 0.33 (0.13, 0.49) | 0.42 (0.25, 0.48) | 0.36 (0.24, 0.49) | NA (NA, NA) | 0.42 (0.37, 0.47) | NA (NA, NA) | 0.44 (0.34, 0.49) | 0.48 (0.39, 0.48) | NA (NA, NA) | 0.34 (0.21, 0.48) | 0.4 (0.21, 0.49) | 0.49 (0.49, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TP53+ | TC5 | r_prob | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TP53+ | TC5 | rate | 0.143 (0.102, 0.274) | 0.18 (0.109, 0.262) | 0.181 (0.106, 0.538) | 0.163 (0.107, 0.312) | 0.091 (0.018, 0.164) | 0.194 (0.099, 1.132) | NA (NA, NA) | 0.167 (0.011, 0.32) | 0.249 (0.077, 0.887) | 0.234 (0.102, 0.367) | 0.172 (0.102, 0.291) | 0.162 (0.096, 0.29) | 0.174 (0.14, 0.207) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC1 | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | ||||||||||||||||
| TEfus+ | TC1 | time | 23 (16, 31) | 23 (16, 31) | 23 (16, 31) | 23 (16, 31) | 23 (16, 31) | 23 (16, 31) | 23 (16, 31) | 23 (16, 31) | 23 (16, 31) | 23 (16, 31) | 23 (16, 31) | 23 (16, 31) | 23 (16, 31) | 23 (16, 31) | 23 (16, 31) | 23 (16, 31) | ||||||||||||||||
| TEfus+ | TC1 | n | 0 (0, 3) | 4 (2, 6) | 2 (1, 4) | 6 (4, 8) | 4 (2, 6) | 2 (1, 2) | 0 (0, 0) | 1 (0, 2) | 3 (2, 4) | 1 (0, 2) | 5 (3, 10) | 4 (3, 5) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC1 | post_p | 0.44 (0.43, 0.46) | 0.44 (0.26, 0.48) | 0.42 (0.32, 0.47) | 0.29 (0.18, 0.45) | 0.41 (0.32, 0.45) | 0.4 (0.26, 0.46) | NA (NA, NA) | 0.48 (0.43, 0.49) | 0.37 (0.24, 0.47) | 0.44 (0.28, 0.46) | 0.31 (0.17, 0.46) | 0.33 (0.18, 0.45) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC1 | r_prob | 0.37 (0.37, 0.37) | 0.22 (0.22, 0.22) | 0.18 (0.18, 0.18) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.14 (0.14, 0.14) | 0.12 (0.12, 0.12) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC1 | rate | 0.247 (0.087, 0.256) | 0.118 (0.101, 0.325) | 0.172 (0.12, 0.526) | 0.19 (0.098, 0.246) | 0.164 (0.127, 0.233) | 0.232 (0.111, 0.326) | NA (NA, NA) | 0.099 (0.035, 0.153) | 0.193 (0.112, 0.309) | 0.337 (0.157, 0.631) | 0.163 (0.116, 0.24) | 0.24 (0.119, 0.328) | 0.07 (0.07, 0.07) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC2 | count | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | ||||||||||||||||
| TEfus+ | TC2 | time | 22 (16, 33) | 22 (16, 33) | 22 (16, 33) | 22 (16, 33) | 22 (16, 33) | 22 (16, 33) | 22 (16, 33) | 22 (16, 33) | 22 (16, 33) | 22 (16, 33) | 22 (16, 33) | 22 (16, 33) | 22 (16, 33) | 22 (16, 33) | 22 (16, 33) | 22 (16, 33) | ||||||||||||||||
| TEfus+ | TC2 | n | 1 (0, 2) | 3 (2, 5) | 2 (0, 4) | 6 (2, 8) | 4 (1, 8) | 2 (0, 3) | 0 (0, 0) | 1 (0, 2) | 2 (0, 4) | 1 (0, 3) | 6 (4, 11) | 5 (2, 7) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC2 | post_p | 0.44 (0.36, 0.49) | 0.39 (0.16, 0.48) | 0.44 (0.32, 0.49) | 0.39 (0.15, 0.46) | 0.36 (0.1, 0.47) | 0.4 (0.37, 0.45) | NA (NA, NA) | 0.39 (0.3, 0.47) | 0.43 (0.37, 0.48) | 0.4 (0.31, 0.46) | 0.42 (0.23, 0.47) | 0.39 (0.27, 0.47) | 0.47 (0.42, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC2 | r_prob | 0.25 (0.25, 0.25) | 0.03 (0.03, 0.03) | 0.41 (0.41, 0.41) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.29 (0.29, 0.29) | 0.37 (0.37, 0.37) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC2 | rate | 0.168 (0.129, 0.28) | 0.148 (0.128, 0.272) | 0.18 (0.131, 0.323) | 0.154 (0.126, 0.547) | 0.19 (0.097, 0.703) | 0.175 (0.076, 0.757) | NA (NA, NA) | 0.259 (0.127, 0.415) | 0.123 (0.102, 0.434) | 0.231 (0.122, 3.646) | 0.139 (0.112, 0.233) | 0.153 (0.126, 0.337) | 0.124 (0.102, 0.166) | NA (NA, NA) | 1.243 (1.243, 1.243) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC3 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||
| TEfus+ | TC3 | time | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | ||||||||||||||||
| TEfus+ | TC3 | n | 2 (2, 2) | 1 (1, 1) | 3 (3, 3) | 3 (3, 3) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 3 (3, 3) | 3 (3, 3) | 0 (0, 0) | 4 (4, 4) | 5 (5, 5) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC3 | post_p | NA (NA, NA) | 0.38 (0.38, 0.38) | 0.45 (0.45, 0.45) | 0.32 (0.32, 0.32) | 0.48 (0.48, 0.48) | NA (NA, NA) | NA (NA, NA) | 0.42 (0.42, 0.42) | 0.49 (0.49, 0.49) | NA (NA, NA) | 0.44 (0.44, 0.44) | 0.17 (0.17, 0.17) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TEfus+ | TC3 | rate | 0.153 (0.153, 0.153) | 0.734 (0.734, 0.734) | 0.097 (0.097, 0.097) | 0.139 (0.139, 0.139) | 0.046 (0.046, 0.046) | NA (NA, NA) | NA (NA, NA) | 0.118 (0.118, 0.118) | 0.144 (0.144, 0.144) | NA (NA, NA) | 0.199 (0.199, 0.199) | 0.221 (0.221, 0.221) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC4 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||||||||||
| TEfus+ | TC4 | time | 30 (25, 30) | 30 (25, 30) | 30 (25, 30) | 30 (25, 30) | 30 (25, 30) | 30 (25, 30) | 30 (25, 30) | 30 (25, 30) | 30 (25, 30) | 30 (25, 30) | 30 (25, 30) | 30 (25, 30) | 30 (25, 30) | 30 (25, 30) | 30 (25, 30) | 30 (25, 30) | ||||||||||||||||
| TEfus+ | TC4 | n | 3 (1, 3) | 5 (1, 5) | 5 (2, 5) | 5 (5, 7) | 3 (1, 5) | 1 (0, 2) | 0 (0, 0) | 0 (0, 0) | 1 (0, 3) | 1 (0, 2) | 9 (6, 10) | 4 (3, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC4 | post_p | 0.47 (0.47, 0.47) | 0.41 (0.37, 0.44) | 0.43 (0.38, 0.46) | 0.3 (0.23, 0.39) | 0.29 (0.24, 0.33) | 0.36 (0.28, 0.43) | NA (NA, NA) | NA (NA, NA) | 0.4 (0.38, 0.41) | 0.47 (0.46, 0.48) | 0.21 (0.18, 0.36) | 0.27 (0.21, 0.43) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| TEfus+ | TC4 | rate | 0.12 (0.114, 0.127) | 0.143 (0.139, 0.146) | 0.104 (0.103, 2.258) | 0.129 (0.123, 0.201) | 0.138 (0.124, 0.151) | 0.34 (0.251, 0.428) | NA (NA, NA) | NA (NA, NA) | 0.214 (0.136, 0.293) | 0.255 (0.152, 0.358) | 0.15 (0.148, 0.166) | 0.22 (0.146, 0.253) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC5 | count | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | ||||||||||||||||
| TEfus+ | TC5 | time | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | 20 (15, 24) | ||||||||||||||||
| TEfus+ | TC5 | n | 1 (0, 3) | 3 (2, 4) | 2 (0, 5) | 7 (3, 9) | 2 (1, 4) | 1 (0, 4) | 0 (0, 0) | 0 (0, 1) | 2 (1, 3) | 0 (0, 1) | 6 (3, 8) | 3 (1, 6) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC5 | post_p | 0.4 (0.36, 0.45) | 0.35 (0.23, 0.45) | 0.38 (0.29, 0.46) | 0.36 (0.26, 0.45) | 0.43 (0.23, 0.49) | 0.4 (0.27, 0.46) | NA (NA, NA) | 0.45 (0.41, 0.48) | 0.42 (0.32, 0.49) | 0.47 (0.42, 0.47) | 0.35 (0.16, 0.45) | 0.4 (0.28, 0.49) | 0.41 (0.4, 0.42) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| TEfus+ | TC5 | r_prob | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| TEfus+ | TC5 | rate | 0.182 (0.079, 0.283) | 0.198 (0.12, 0.254) | 0.287 (0.155, 0.665) | 0.182 (0.119, 0.228) | 0.168 (0.101, 0.529) | 0.179 (0.068, 0.741) | NA (NA, NA) | 0.324 (0.019, 3.61) | 0.203 (0.101, 0.364) | 0.17 (0.073, 0.548) | 0.173 (0.1, 0.206) | 0.149 (0.098, 0.83) | 0.126 (0.032, 11.878) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC1 | count | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | 23 | ||||||||||||||||
| PI3K+ | TC1 | time | 23 (15, 30) | 23 (15, 30) | 23 (15, 30) | 23 (15, 30) | 23 (15, 30) | 23 (15, 30) | 23 (15, 30) | 23 (15, 30) | 23 (15, 30) | 23 (15, 30) | 23 (15, 30) | 23 (15, 30) | 23 (15, 30) | 23 (15, 30) | 23 (15, 30) | 23 (15, 30) | ||||||||||||||||
| PI3K+ | TC1 | n | 8 (5, 13) | 3 (1, 6) | 8 (4, 12) | 6 (3, 10) | 0 (0, 0) | 1 (0, 4) | 0 (0, 2) | 1 (0, 3) | 0 (0, 2) | 1 (0, 3) | 0 (0, 0) | 4 (2, 7) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC1 | post_p | 0.34 (0.16, 0.46) | 0.35 (0.24, 0.45) | 0.35 (0.18, 0.47) | 0.31 (0.14, 0.47) | NA (NA, NA) | 0.43 (0.38, 0.47) | 0.43 (0.35, 0.49) | 0.43 (0.39, 0.49) | 0.41 (0.3, 0.47) | 0.4 (0.3, 0.48) | NA (NA, NA) | 0.4 (0.21, 0.45) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC1 | r_prob | 0.22 (0.22, 0.22) | 0.22 (0.22, 0.22) | 0.13 (0.13, 0.13) | 0.09 (0.09, 0.09) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.14 (0.14, 0.14) | 0.14 (0.14, 0.14) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC1 | rate | 0.153 (0.113, 0.205) | 0.174 (0.124, 0.32) | 0.155 (0.11, 0.302) | 0.184 (0.095, 0.276) | NA (NA, NA) | 0.103 (0, 1.197) | 0.152 (0.042, 1.689) | 0.106 (0.019, 0.345) | 0.229 (0.074, 0.894) | 0.277 (0.105, 0.62) | NA (NA, NA) | 0.157 (0.111, 0.36) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC2 | count | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | ||||||||||||||||
| PI3K+ | TC2 | time | 24 (14, 30) | 24 (14, 30) | 24 (14, 30) | 24 (14, 30) | 24 (14, 30) | 24 (14, 30) | 24 (14, 30) | 24 (14, 30) | 24 (14, 30) | 24 (14, 30) | 24 (14, 30) | 24 (14, 30) | 24 (14, 30) | 24 (14, 30) | 24 (14, 30) | 24 (14, 30) | ||||||||||||||||
| PI3K+ | TC2 | n | 6 (2, 11) | 3 (1, 9) | 8 (4, 10) | 5 (2, 7) | 0 (0, 0) | 1 (0, 4) | 0 (0, 3) | 0 (0, 2) | 0 (0, 1) | 1 (0, 2) | 0 (0, 0) | 5 (2, 7) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC2 | post_p | 0.34 (0.19, 0.47) | 0.42 (0.25, 0.5) | 0.38 (0.16, 0.48) | 0.37 (0.18, 0.47) | NA (NA, NA) | 0.44 (0.37, 0.48) | 0.44 (0.4, 0.49) | 0.46 (0.43, 0.49) | 0.44 (0.36, 0.49) | 0.45 (0.37, 0.49) | NA (NA, NA) | 0.41 (0.28, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC2 | r_prob | 0.03 (0.03, 0.03) | 0.03 (0.03, 0.03) | 0.07 (0.07, 0.07) | 0.16 (0.16, 0.16) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.21 (0.21, 0.21) | 0.21 (0.21, 0.21) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC2 | rate | 0.149 (0.104, 0.341) | 0.172 (0.105, 0.409) | 0.147 (0.115, 0.214) | 0.155 (0.121, 0.524) | NA (NA, NA) | 0.121 (0.078, 0.936) | 0.155 (0.048, 0.23) | 0.201 (0.126, 0.471) | 0.616 (0.181, 1.581) | 0.184 (0, 0.652) | NA (NA, NA) | 0.15 (0.106, 0.324) | 0.239 (0.239, 0.239) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC3 | count | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | ||||||||||||||||
| PI3K+ | TC3 | time | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | 18 (15, 22) | ||||||||||||||||
| PI3K+ | TC3 | n | 8 (5, 10) | 5 (2, 8) | 5 (4, 8) | 7 (3, 9) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 2) | 1 (0, 2) | 0 (0, 0) | 4 (2, 6) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC3 | post_p | 0.42 (0.25, 0.45) | 0.43 (0.24, 0.46) | 0.36 (0.15, 0.46) | 0.32 (0.19, 0.42) | NA (NA, NA) | 0.43 (0.43, 0.43) | 0.48 (0.48, 0.48) | 0.47 (0.45, 0.49) | NA (NA, NA) | 0.42 (0.39, 0.47) | NA (NA, NA) | 0.36 (0.28, 0.44) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| PI3K+ | TC3 | rate | 0.141 (0.103, 0.22) | 0.164 (0.104, 0.832) | 0.165 (0.104, 0.219) | 0.152 (0.119, 0.267) | NA (NA, NA) | 0.186 (0.037, 0.243) | 1.36 (0.382, 2.337) | 0.076 (0.019, 0.193) | 0.215 (0.19, 0.24) | 0.269 (0.086, 0.799) | NA (NA, NA) | 0.17 (0.107, 0.327) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC4 | count | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | ||||||||||||||||
| PI3K+ | TC4 | time | 18 (14, 28) | 18 (14, 28) | 18 (14, 28) | 18 (14, 28) | 18 (14, 28) | 18 (14, 28) | 18 (14, 28) | 18 (14, 28) | 18 (14, 28) | 18 (14, 28) | 18 (14, 28) | 18 (14, 28) | 18 (14, 28) | 18 (14, 28) | 18 (14, 28) | 18 (14, 28) | ||||||||||||||||
| PI3K+ | TC4 | n | 7 (4, 10) | 4 (3, 7) | 7 (5, 10) | 4 (1, 9) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 1 (0, 2) | 0 (0, 2) | 0 (0, 0) | 4 (2, 6) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC4 | post_p | 0.31 (0.09, 0.46) | 0.36 (0.19, 0.44) | 0.36 (0.3, 0.48) | 0.43 (0.28, 0.48) | NA (NA, NA) | 0.42 (0.42, 0.42) | 0.48 (0.44, 0.49) | 0.37 (0.37, 0.37) | 0.47 (0.46, 0.49) | 0.42 (0.4, 0.45) | NA (NA, NA) | 0.34 (0.17, 0.42) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC4 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||||
| PI3K+ | TC4 | rate | 0.209 (0.115, 0.321) | 0.17 (0.124, 0.324) | 0.168 (0.119, 0.202) | 0.133 (0.1, 0.199) | NA (NA, NA) | 0.143 (0.143, 0.143) | 0.072 (0, 0.91) | 0.479 (0.479, 0.479) | 0.16 (0, 0.274) | 0.216 (0.098, 0.83) | NA (NA, NA) | 0.234 (0.152, 0.331) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0.651 (0.651, 0.651) | ||||||||||||||||
| PI3K+ | TC5 | count | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | ||||||||||||||||
| PI3K+ | TC5 | time | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | 23 (13, 33) | ||||||||||||||||
| PI3K+ | TC5 | n | 8 (3, 14) | 3 (1, 5) | 7 (3, 11) | 6 (3, 10) | 0 (0, 0) | 2 (0, 3) | 1 (0, 2) | 0 (0, 2) | 0 (0, 1) | 1 (0, 2) | 0 (0, 0) | 4 (2, 8) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC5 | post_p | 0.38 (0.22, 0.48) | 0.41 (0.2, 0.48) | 0.31 (0.14, 0.48) | 0.4 (0.22, 0.45) | NA (NA, NA) | 0.39 (0.29, 0.45) | 0.44 (0.33, 0.47) | 0.43 (0.35, 0.49) | 0.44 (0.32, 0.49) | 0.43 (0.36, 0.48) | NA (NA, NA) | 0.42 (0.29, 0.49) | NA (NA, NA) | 0.44 (0.44, 0.44) | NA (NA, NA) | NA (NA, NA) | ||||||||||||||||
| PI3K+ | TC5 | r_prob | 0.38 (0.38, 0.38) | 0.38 (0.38, 0.38) | 0.33 (0.33, 0.33) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||||
| PI3K+ | TC5 | rate | 0.143 (0.103, 0.242) | 0.212 (0.133, 0.447) | 0.166 (0.113, 0.251) | 0.157 (0.109, 0.226) | NA (NA, NA) | 0.132 (0.077, 0.369) | 0.264 (0.147, 2.309) | 0.159 (0, 1.092) | 0.259 (0.053, 1.416) | 0.17 (0.095, 0.578) | 0.4 (0.4, 0.4) | 0.149 (0.106, 0.302) | 0.335 (0.335, 0.335) | 0.282 (0.282, 0.282) | NA (NA, NA) | 0 (0, 0) |